Regulatory Mechanisms of Striated Muscle Contraction

Front Matter....Pages I-XIII
Front Matter....Pages 1-1
Biological Actions of Calcium....Pages 3-6
Professor Ebashi’s Journey Toward the Discovery of Troponin: A Personal Recollection....Pages 7-9
Highlights of the History of Calcium Regulation of Striated Muscle....Pages 11-18
Front Matter....Pages 19-19
Troponin: Structure, Function and Dysfunction....Pages 21-36
From the Crystal Structure of Troponin to the Mechanism of Calcium Regulation of Muscle Contraction....Pages 37-46
Ca Ion and the Troponin Switch....Pages 47-57
Disposition and Dynamics: Interdomain Orientations in Troponin....Pages 59-70
Structural Basis for Calcium-Regulated Relaxation of Striated Muscles at Interaction Sites of Troponin with Actin and Tropomyosin....Pages 71-86
Tropomyosin: Regulator of Actin Filaments....Pages 87-97
Tropomyosin and Troponin Cooperativity on the Thin Filament....Pages 99-109
Conformational Changes in Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Spectroscopy....Pages 111-123
Calcium Structural Transition of Troponin in the Complexes, on the Thin Filament, and in Muscle Fibres, as Studied By Site-Directed Spin-Labelling EPR....Pages 125-135
Crystal Structures of Tropomyosin: Flexible Coiled-Coil....Pages 137-151
 C. Elegans Model for Studying Tropomyosin and Troponin Regulations of Muscle Contraction and Animal Behavior....Pages 153-161
Structural and Functional Analysis of Troponins from Scallop Striated and Human Cardiac Muscles....Pages 163-173
Front Matter....Pages 175-175
Cooperativity in the Regulation of Force and the Kinetics of Force Development in Heart and Skeletal Muscles....Pages 177-189
Heart Failure, Ischemia/Reperfusion Injury and Cardiac Troponin....Pages 191-200
Troponin Mutations in Cardiomyopathies....Pages 201-226
Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T....Pages 227-239
Cardiac Troponin Levels as a Preferable Biomarker of Myocardial Cell Degradation....Pages 241-249
Front Matter....Pages 251-251
Regulation by Myosin: How Calcium Regulates Some Myosins, Past and Present....Pages 253-264
Calcium Inhibition of Physarum Myosin as Examined by the Recombinant Heavy Mero-Myosin....Pages 265-272
Front Matter....Pages 273-273
Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum....Pages 275-285
Dysregulation of the Gain of CICR Through Ryanodine Receptor1 (RyR1): The Putative Mechanism Underlying Malignant Hyperthermia....Pages 287-294
Ion Pumping by Calcium ATPase of Sarcoplasmic Reticulum....Pages 295-303
Regulation of Cell Functions by Ca 2+ Oscillation....Pages 305-312
Front Matter....Pages 313-313
Evidence About the Structural Behaviour of Myosin Crossbridges During Muscle Contraction....Pages 315-326
Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction....Pages 327-340
Regulation of Muscle Contraction by Ca 2+ and ADP: Focusing on the0 Auto-Oscillation (SPOC)....Pages 341-358
Muscle Contraction Mechanism Based on Actin Filament Rotation....Pages 359-367
On the Walking Mechanism of Linear Molecular Motors....Pages 369-384
Modeling of the F-Actin Structure....Pages 385-401
Back Matter....Pages 405-407