Regulation of Phosphate and Mineral Metabolism

Front Matter....Pages i-xv
Front Matter....Pages xvii-xvii
The Adaptive System of the Tubular Transport of Phosphate....Pages 1-11
Nephron Sites of Adaptation to Changes in Dietary Phosphate....Pages 13-19
Phosphate Reabsorption in the Distal Convoluted Tubule....Pages 21-32
Metabolic Abnormalities Underlying the Pathogenesis of Vitamin D Resistant Rickets (VDRR)....Pages 33-40
Relationship between Plasma Phosphate and Renal Handling of Phosphate: Studies with Low Phosphate Diet and Nicotinamide....Pages 41-46
Protein Phosphorylation in Proximal Tubular Brush-Border Membranes....Pages 47-54
Possible Relationship of Gluconeogenesis to Modulation of Phosphate Transport in the Proximal Tubule....Pages 55-64
Interactions Between Phosphate Transport and Oxidative Metabolism in the Rabbit Proximal Tubule....Pages 65-69
Abnormal Tubular Pi Adaptation to Dietary Pi Restriction and Decreased Calcium Reabsorption in X-Linked Hypophosphatemic (HYP) MICE....Pages 71-75
Renal Pi Transport in Young Growing and Adult Rats: Comparative Studies in Brush Border Membrane Vesicles (BBMV) and in Whole Kidney....Pages 77-79
Difference in Renal Tubular Transport Effects of 1–34 and 1–84 Parathyroid Hormone (PTH)....Pages 81-82
1,25-Dihydroxycholecalciferol (Calcitriol): Effect on Phosphate (PO 4 ) Absorption by Isolated Pars Recta....Pages 83-85
 In Vivo and in Vitro Effects of Vitamin D 3 [1,25-(OH) 2 D 3 ] on the Uptake of Phosphate by Isolated Chick Kidney Cells....Pages 87-95
Potassium Imbalance and Phosphate Renal Handling: A Micropuncture Study....Pages 97-102
Renal Handling of Divalent Cations and Phosphate During Water Immersion in the Awake Dog....Pages 103-109
The Effects of Calcium on ADH Action in Cortical Collecting Tubules Perfused In Vitro ....Pages 111-112
Front Matter....Pages 113-113
The Creatine-Creatine Phosphate Shuttle for Energy Transport — Compartmentation of Creatine Phosphokinase in Muscle....Pages 115-125
Hormonal Regulation of Phosphate Transport in the Differentiating Chick Small Intestine....Pages 127-135
Measurement of Intracellular Inorganic Phosphate in Human Blood Red Cells, Leucocytes and Platelets....Pages 137-146
Intracellular Inorganic Phosphate and ATP Levels in Human Blood Erythrocytes, Leucocytes and Platelets in Normal Subjects and in Diseases Associated with Altered Phosphate Metabolism....Pages 147-155
Front Matter....Pages 113-113
Prevention of Phosphate Induced Progression of Experimental Uremia by 3-Phosphocitric Acid....Pages 157-166
Phosphate Homeostasis in Cimetidine Treated Uremic Dogs....Pages 167-176
Regulation of Phosphate Excretion by the Diseased Kidney: The Intrinsic Proximal Tubular Adaptation....Pages 177-183
Parathyroid Hormone Resistance in Renal Allograft Recipients....Pages 185-187
Front Matter....Pages 189-189
Models of Hypophosphatemia and Phosphate Depletion....Pages 191-198
Effects of Phosphate Depletion on the Myocardium....Pages 199-207
Hypophosphatemia and Osteoblast Function in Human Bone Disease....Pages 209-216
Hypophosphatemia and Glucose Intolerance....Pages 217-228
Acute Hypophosphatemia during Total Parenteral Nutrition in Man: Its Effects on Muscle Cell Composition....Pages 229-238
Proximal Renal Tubular Acidosis and Hypophosphatemia Induced by Arginine....Pages 239-249
Cardiac Function and Metabolism in Phosphorous Depleted Dogs — Effects of Hormonal Stimulation....Pages 251-258
Circulatory Response to Pressor Agents in Phosphorous Depletion....Pages 259-265
Phosphate and Vanadate Reduce the Efficiency of the Chemo-Mechanical Energy Transformation in Cardiac Muscle....Pages 267-281
Effects of Hypophosphatemia on Pulmonary Muscle Performance....Pages 283-290
Experimental Alcoholism Induces Phosphorus and Magnesium Deficiency in Skeletal Muscle....Pages 291-302
Defective Hormonal Stimulation of Isolated Hepatocytes in Phosphorous Depleted Rats....Pages 303-308
Should Hypophosphatemia be Treated?....Pages 309-316
Front Matter....Pages 317-317
Development and Application of an Exchange Assay for 1,25-Dihydroxyvitamin D 3 ....Pages 319-331
Effects of Systemic pH on Calcium Regulating Hormones and Bone....Pages 333-339
Inherited and Acquired Disorders of Vitamin D Metabolism....Pages 341-354
Front Matter....Pages 317-317
The Molecular Nature of 1,25-(OH) 2 -D 3 -Induced Calcium-Binding Protein Biosynthesis in the Rat....Pages 355-360
Effects of 1,25-Dihydroxy Vitamin D 3 in Patients with Early Renal Failure....Pages 361-373
Increased Serum 1,25-(OH) 2 -Vitamin D Concentrations Fail to Affect Serum or Urine Phosphate in Humans....Pages 375-383
Adrenergic Blockade May Inhibit the Increase in Plasma 1,25-(OH) 2 -Vitamin D During Phosphate Deprivation in the Rat....Pages 385-389
Front Matter....Pages 391-391
Regulation of Osteoblast Activity and the Osteoblast-Osteocyte Transformation....Pages 393-400
Role of Monocytes in Bone Resorption....Pages 401-408
Coupling Factor....Pages 409-421
Glutamine: A New Metabolic Substrate....Pages 423-428
Evolution of Renal Osteodystrophy in Patients Treated by Continuous Ambulatory Peritoneal Dialysis....Pages 429-440
Front Matter....Pages 441-441
Measurements of Intracellular Free Ca ++ ....Pages 443-459
The Regulation of Intracellualr Calcium....Pages 461-472
Calcium as Intracellular Messenger in Hormone Action....Pages 473-491
Effects of Diuretics on Calcium Metabolism....Pages 493-500
Effects of Chlorothiazide Administration and Dietary Calcium Restriction on Parathyroid Function, Vitamin D Metabolism and Intestinal Calcium Absorption in the Rat....Pages 501-507
Calcium Fluxes Across Membranes Isolated from Small Intestinal Epithelium....Pages 509-517
Front Matter....Pages 519-519
The Parathyroid Hormone Molecule: Biological Implications of Structure....Pages 521-534
Functional Properties of Parathyroid Hormone Receptors in Kidney and Bone....Pages 535-548
Assessment of Biologically Active Parathyroid Hormone in Hyperparathyroid Man....Pages 549-559
Effect of Parathyroid Hormone on Phospholipid Metabolism....Pages 561-575
Effects of Parathyroid Hormone on Glomerular Ultrafiltration in the Rat....Pages 577-585
Front Matter....Pages 519-519
Regulation Mechanisms of the Renal Phosphate Handling in Renal Failure — What is the Role of PTH?....Pages 587-596
Interactions Between Liver and Parathyroid Hormone....Pages 597-605
Parathyroid Hormone and the Heart....Pages 607-618
Vascular Effects of Parathyroid Hormone (PTH)....Pages 619-632
Role of PTH, Metabolic Factors and Other Hormones in Extra-Renal Acid Buffering....Pages 633-648
Effect of Parathyroid Hormone on the Isolated Papillary Muscle of the Rat Heart....Pages 649-656
Effect of Parathyroid Hormone on Rat Enterocyte Na Transport in Vitro....Pages 657-665
Comparison of Propranolol and Atenolol in the Control of Hyperparathyroidism in Uremia....Pages 667-676
Effects of Oral Cimetidine on Parathyroid Hormone and Calcitonin Plasma Levels in Uremic Patients....Pages 677-684
Back Matter....Pages 685-702