Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology: Scientific and Clinical Aspects of Anemia in Cancer

Front Matter....Pages i-ix
Biology of erythropoietin....Pages 1-21
Classification and characterization of anemia in cancer....Pages 23-38
Pathophysiology of cancer-related anemia....Pages 39-62
Prevalence, pathophysiology, predictive factors, and prognostic significance of anemia in cancer chemotherapy....Pages 63-100
Incidence and impact of anemia in radiation oncology....Pages 101-115
Relationship between anemia and tumor hypoxia....Pages 117-125
Tumor hypoxia and therapeutic resistance....Pages 127-146
Impact of anemia on organ functions....Pages 147-172
Relationship between anemia, fatigue, and quality of life in cancer patients....Pages 173-184
Red blood cell transfusion, risks and limitations....Pages 185-201
Pharmacology, pharmacokinetics and safety of recombinant human erythropoietin (rhEPO)....Pages 203-221
Recombinant human erythropoietin (rhEPO) in anemia associated with multiple myeloma and non-Hodgkin’s lymphoma....Pages 223-234
Use of recombinant human erythropoietin in the treatment of myelodysplastic syndromes....Pages 235-239
rhEPO in anemia associated with solid tumors and chemotherapy....Pages 241-262
Predictive factors for response of anemia to recombinant human erythropoietin....Pages 263-286
rhEPO in hematopoietic stem cell mobilization, transplantation and in-vitro expansion....Pages 287-299
Clinical trials using rhEPO in radiation oncology....Pages 301-311
rhEPO in pediatric oncology....Pages 313-323
rHuEPO in surgical oncology....Pages 325-346
Erythropoiesis, iron metabolism and iron supplementation during erythropoietin therapy....Pages 347-368
Optimal level of hemoglobin in cancer patients....Pages 369-390
Protection of metabolic and exercise capacity following treatment with recombinant erythropoietin....Pages 391-404
Effects of treatment with rhEPO on quality of life in anemic cancer patients....Pages 405-424
Effect of rhEPO on survival in anaemic cancer patients receiving chemotherapy....Pages 425-433
Cost-effectiveness of rHu-EPO in oncology....Pages 435-446
Current status and future developments of rhEPO in clinical oncology....Pages 447-492
Back Matter....Pages 493-506