Receptor Chemistry Towards the Third Millennium

Content: 
Preface
Page v
Ugo Gulini, Mario Giannella, Gabriella Marucci, Wilma Quaglia

Acknowledgements
Page vi

Pharmacological receptors: a century of discovery — and more Original Research Article
Pages 79-84
David J. Triggle

Cholinergic receptors and neurodegenerative diseases Original Research Article
Pages 85-89
Fulvio Gualtieri

Nicotinic systems in central nervous systems disease: degenerative disorders and beyond Original Research Article
Pages 91-101
Paul A. Newhouse, Megan Kelton

Central nicotinic receptor ligands and pharmacophores Original Research Article
Pages 103-114
Richard A. Glennon, Małgorzata Dukat

Structural aspects of high affinity ligands for the α4β2 neuronal nicotinic receptor Original Research Article
Pages 115-123
Michael J. Dart, James T. Wasicak, Keith B. Ryther, Michael R. Schrimpf, Ki H. Kim, David J. Anderson, James P. Sullivan, Michael D. Meyer

Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist Original Research Article
Pages 125-130
Nicholas D.P. Cosford, Leo Bleicher, Jean-Michel Vernier, Laura Chavez-Noriega, Tadimeti S. Rao, Robert S. Siegel, Carla Suto, Mark Washburn, G. Kenneth Lloyd, Ian A. McDonald

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors Original Research Article
Pages 131-134
Piero Angeli

Design and development of selective muscarinic agonists for the treatment of alzheimer\'s disease: characterization of tetrahydropyrimidine derivatives and dev Original Research Article
Pages 135-140
William S. Messer Jr., W.G. Rajeswaran, Yang Cao, Hai-Jun Zhang, Afif A. El-Assadi, Colleen Dockery, Jill Liske, John O\'Brien, Frederick E. Williams, Xi-Ping Huang, Mary E. Wroblewski, Peter I. Nagy, Steven M. Peseckis

CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology Original Research Article
Pages 141-148
H. Tecle, R.D. Schwarz, S.D. Barrett, M.J. Callahan, B.W. Caprathe, R.E. Davis, P. Doyle, M. Emmerling, D.J. Lauffer, T. Mirzadegan, D.W. Moreland, W. Lipiniski, C. Nelson, C. Raby, C. Spencer, K. Spiegel, A.J. Thomas, J.C. Jaen

Ligands for the common allosteric site of acetylcholine M2-receptors: development and application Original Research Article
Pages 149-155
U. Holzgrabe, W. Bender, H.M. Botero Cid, M. Staudt, R. Pick, C. Pfletschinger, E. Balatková, C. Tränkle, K. Mohr

Receptors in cardiovascular disease: review and introduction Original Research Article
Pages 157-161
Amedeo Leonardi, Giorgio Sironi, Gianni Motta

Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics Original Research Article
Pages 163-171
J. Paul Hieble

The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action Original Research Article
Pages 173-179
Susanna Cotecchia, Olivier Rossier, Francesca Fanelli, Amedeo Leonardi, Pier G. De Benedetti

α1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety Original Research Article
Pages 181-190
C. Melchiorre, P. Angeli, M.L. Bolognesi, A. Chiarini, D. Giardin`, U. Gulini, A. Leonardi, G. Marucci, A. Minarini, M. Pigini, W. Quaglia, M. Rosini, V. Tumiatti

Selection, design and evaluation of new radioligands for PET studies of cardiac adrenoceptors Original Research Article
Pages 191-200
V.W. Pike, M.P. Law, S. Osman, R.J. Davenport, O. Rimoldi, D. Giardin`, P.G. Camici

Enigmatic receptors Original Research Article
Pages 201-203
Livio Brasili

Imidazoline receptors: a challenge Original Research Article
Pages 205-209
Pascal Bousquet, Véronique Bruban, Stephan Schann, Josiane Feldman

Sigma receptors: recent advances and new clinical potentials Original Research Article
Pages 211-218
Wayne D. Bowen

Excitatory amino acid receptors Original Research Article
Pages 219-220
G. Gaviraghi

Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications Original Research Article
Pages 221-229
D.G. Trist

Metabotropic glutamate receptors: a structural view point
Pages 231-237
Roberto Pellicciari, Gabriele Costantino, Antonio Macchiarulo

Synthesis and pharmacological properties of novel glycine antagonists Original Research Article
Pages 239-245
D. Donati, R. Di Fabio

Receptors in neurodegenerative diseases Original Research Article
Pages 247-251
Wolfgang Froestl

Neurotrophin receptor structure and interactions Original Research Article
Pages 253-260
Hiroko Yano, Moses V. Chao

The RET receptor tyrosine kinase: activation, signalling and significance in neural development and disease Original Research Article
Pages 261-264
Ivor Mason

The ciliary neurotrophic factor and its receptor, CNTFRα Original Research Article
Pages 265-272
Mark W. Sleeman, Keith D. Anderson, Philip D. Lambert, George D. Yancopoulos, Stanley J. Wiegand

Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer\'s disease and stroke Original Research Article
Pages 273-280
Sylvain Doré, Satyabrata Kar, When-Hua Zheng, Rémi Quirion

Apoptosis induced by death receptors Original Research Article
Pages 281-286
Pascal Schneider, Jürg Tschopp

Hijacked receptors Original Research Article
Pages 287-290
David J. Triggle

ICAM-1 receptors and cold viruses Original Research Article
Pages 291-297
Jordi Bella, Michael G. Rossmann

Viral-encoded G-protein coupled receptors: new targets for drug research? Original Research Article
Pages 299-304
Martine J. Smit, Henk Timmerman, Dennis Verzijl, Rob Leurs

Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines Original Research Article
Pages 305-312
Silvano Sozzani, Paola Allavena, Annunciata Vecchi, Jo Van Damme, Alberto Mantovani

General topics and perspectives Original Research Article
Pages 313-314
H. Timmerman

Pharmacological evidence of muscarinic receptor heterodimerization Original Research Article
Pages 315-326
S. Chiacchio, M. Scarselli, M. Armogida, R. Maggio

Constitutive activity of G protein coupled receptors and drug action Original Research Article
Pages 327-331
Rob Leurs, Maria Sol Rodriguez Pena, Remko A. Bakker, Astrid E. Alewijnse, Henk Timmerman

New dimensions in G protein signalling: Gβ5 and the RGS proteins Original Research Article
Pages 333-336
William F. Simonds, Jian-Hua Zhang

Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse Original Research Article
Pages 337-344
John L. Neumeyer, Nancy K. Mello, S. Stevens Negus, Jean M. Bidlack

Author index
Pages 345-346

Keyword index
Pages 347-349