Receptor biology

Content: Title Page
 Copyright
 Dedication
 Table of Contents
 Acknowledgments
 Part I: Introduction
 Chapter 1: Introduction
 1.1 Receptors and Signaling
 1.2 Types of Receptors and Hormones
 1.3 Receptors Are the Chemical Expression of Reality
 Chapter 2: The Origins of Chemical Thinking
 2.1 Overview of Early Pharmacological History
 2.2 Modern Pharmacology
 2.3 Phylogenetics of Signaling
 Part II: Fundamentals
 Chapter 3: Membranes and Proteins
 3.1 Membranes
 3.2 The Nature and Function of Proteins
 Chapter 4: Hormones as First Messengers
 4.1 Hormones and Cellular Communication 4.2 Types of Hormones4.3 Vertebrate Hormones and Transmitters
 4.4 Analgesics and Venoms as Receptor Ligands
 Chapter 5: Receptor Theory
 5.1 The Materialization of Receptors
 5.2 Receptor Mechanisms
 5.3 Binding Theory
 5.4 Visualizing Receptor Structure and Function
 5.5 Proteomics Approaches to Receptor Efficacy
 5.6 Physical Factors Affecting Receptor Binding
 Part III: Receptor Types and Function
 Chapter 6: Transduction I: Ion Channels and Transporters
 6.1 Introduction
 6.2 Small Molecule Channels
 6.3 Transporters
 6.4 Major Intrinsic Proteins
 6.5 Ligand-Gated Ion Channels Chapter 7: Transduction II: G-Protein-Coupled Receptors7.1 Introduction
 7.2 Families of G-Protein-Coupled Receptors
 7.3 Transduction Mechanisms
 7.4 The Major Families of G Protein-Coupled Receptors
 Chapter 8: Transduction III: Receptor Kinases and Immunoglobulins
 8.1 Protein Kinases
 8.2 Receptors for Cell Division and Metabolism
 8.3 Receptor Serine/Threonine Kinases
 8.4 The Guanylyl Cyclase Receptor Subfamily --
Natriuretic Peptide Receptors
 8.5 Non-Kinase Molecules --
LDL Receptors
 8.6 Cell-Cell Contact Signaling
 8.7 Immune System Receptors, Antibodies, and Cytokines Chapter 9: Transduction IV: Nuclear Receptors9.1 Introduction
 9.2 Genomic Actions of Nuclear Receptors
 9.3 Actions of Receptor Antagonists
 9.4 Non-Traditional Actions of Steroid-Like Hormones and Their Receptors
 Part IV: Applications
 Chapter 10: Signaling Complexity
 10.1 Introduction
 10.2 Experimental Determination of Signaling Cascades
 10.3 Transduction across the Membrane
 10.4 Complexity in Cross Talk --
Roles of PIP3, Akt, and PDK1
 10.5 Role in Cancer
 10.6 Signaling Mediated by Gas Molecules
 Chapter 11: Cellular Interactions in Development
 11.1 Introduction 11.2 The Origins of Multicellularity11.3 The Origin of Symmetry and Axes
 11.4 Fertilization and Organization of the Multicellular Body Plan
 11.5 Differentiation of Triploblastic Embryos --
Organogenesis
 11.6 Programmed Cell Death (Apoptosis)
 Chapter 12: Receptor Mechanisms in Disease Processes
 12.1 Genetic Basis for Receptor Function
 12.2 Receptor Pathologies
 12.3 Signaling Mutations Leading to Cancer
 Chapter 13: Receptors and the Mind
 13.1 Origins of Behavior
 13.2 Nervous Systems
 13.3 Animal Memory: Invertebrates
 13.4 Animal Memory: Vertebrates