Recent Developments in Toxicology: Trends, Methods and Problems: Proceedings of the European Societies of Toxicology Meeting Held in Leipzig, September 12–14, 1990

Front Matter....Pages I-X
Front Matter....Pages 1-1
 In Vitro Assessment of Antidotes to Organophosphorus Toxicity....Pages 3-7
Primary Cultures of Adult Mammalian Sensory Neurons and Other in Vitro Systems of Use in Neurotoxicological Studies....Pages 8-14
Animal Models in Behavioural Toxicology and Teratology....Pages 15-24
Cytotoxic Brain Oedema as a Model in the Examination of Cerebroprotective Substances....Pages 25-29
Neurochemical Characterization of Hexachlorophene Induced Brain Oedema....Pages 30-32
The Effects of Organophosphorous Compounds on the Central Nervous System of Rats....Pages 33-37
The Effects of n-Hexane and its Metabolites on Erythrocyte and Synaptosome Membrane Acetylcholinesterase in Vitro ....Pages 38-40
Front Matter....Pages 41-41
Assessment of Toxicopathological Effects in Ageing Laboratory Rodents....Pages 43-49
New Microtechniques in Toxicopathology....Pages 50-54
Tumor Registry Data Base: Systematized Nomenclature of Preneoplastic and Neoplastic Lesions in Rat Gonads....Pages 55-57
Mortality and Neoplastic Lesions in Untreated Sprague-Dawley Rats....Pages 58-62
Investigations on the Sensitivity of Several Biochemical and Histological Methods after Liver Intoxication Induced by Pentachlorophenol and Carbon Tetrachloride....Pages 63-67
The Glutathione System in Rat Liver Chronically Injured by Thioacetamide....Pages 68-70
Hitherto Unknown Additive Growth Effects of Fluorene and 2-Acetylaminofluorene on Bile Duct Epithelium and Hepatocytes in Rats....Pages 71-74
Morphological Lesions of Pancreas and Bile Ducts in Rats Induced by Dibutyltin Dichloride....Pages 75-79
Toxic Action of Platinum Coordination Complexes on the Endocrine Pancreas of the Rat....Pages 80-82
Investigations of Myelotoxic Effects in Rats....Pages 83-87
The Effect of Aluminium Loading on Bones of Mice....Pages 88-91
Cobalt Particles, Identified by Energy-Dispersive X-Ray Microanalysis, in Diamond Polisher’s Lung....Pages 92-95
Density of Gastroendocrine Cells in Cynomolgus Monkey and Other Species....Pages 96-99
Front Matter....Pages 41-41
Computerised Analysis of Pathological Findings in Longterm Trials with Phenylmercuric Acetate in Rats....Pages 100-103
Front Matter....Pages 105-105
Preclinical Assessment of the Cardiotoxic Potential of Anthracycline Antibiotics: N-L-Leucyl-Doxorubicin....Pages 107-117
Hypertension is not exacerbated by Chronic Carbon Monoxide Exposure, with or without Added Salt, in the Borderline Hypertensive Rat....Pages 118-123
Cardiovascular System and Kidney as Specific Targets of Chronic Exposure to Vanadate in the Rat: Functional and Morphological Findings....Pages 124-127
Acute Effects of Dichloromethane on Arrhythmia Development During the Early Phase of Myocardial Ischemia and Reperfusion in the Rat....Pages 128-131
Pharmacokinetics of Total and Free Digoxin and Fab Fragments in 5 Intoxicated Patients after Administration of Specific Anti-Digoxin Fab Fragments....Pages 132-135
Use of Spontaneously Beating Heart Muscle Cells Differentiating from Pluripotential Embryonic Stem Cells for Testing of Chronotropic Agents....Pages 136-139
Characterization of the Hypotensive Side Effect of Macrolide Antibiotics in Animals....Pages 140-143
Front Matter....Pages 145-145
Toxic Influences on Platelet Function....Pages 147-152
Hereditary and Acquired Disturbances of Haemostasis in Animals....Pages 153-156
Effects of Snake Venoms on Tissue-Type Plasminogen Activator Release....Pages 157-159
Metabolic and Toxicological Studies on the Anticoagulant Rodenticide, Flocoumafen....Pages 160-165
Influence of Natural Humic Acids and Synthetic Phenolic Polymers on Haemostasis....Pages 166-169
A Comparison of the Thrombogenic Activity of Prothrombin Complex Concentrates Using Stasis and Non-stasis Models....Pages 170-173
Inhibition of Platelet Aggregation and Thromboxane A 2 Production by Chlorophenoxy Acid Herbicides....Pages 174-178
Front Matter....Pages 179-179
The Effect of Paracetamol on the Hepatic Uptake of Microparticles in Vivo and in Vitro ....Pages 181-184
Influence of Iron Chelators, 1,2-Dialkyl-3-Hydroxypyridin-4-Ones, on the Lipid Peroxidation and Glutathione Level in the Liver of Mice....Pages 185-187
The Influence of Cytochrome P-450 Inducers on Carbonyl Reduction in Mouse Liver....Pages 188-192
Influence of Inducers of Cytochrome P-450 on Dealkylation of 7-Alkoxycoumarins....Pages 193-196
The Effect of Monoclonal Antibodies on Dipyrone-Induced Rat Liver Cytochrome P450....Pages 197-200
Front Matter....Pages 179-179
Antipyrine Metabolism in Coke Oven Workers....Pages 201-204
Influence of Bile Acids on the Development of Hepatic Transport of Organic Anions....Pages 205-208
Comparative Nephrotoxicity Studies of Cisplatin and its Iodinized Derivative in Rats....Pages 209-212
Inhibitory Effects of a Platelet Activating Factor-Antagonist 48740RP in Cyclosporin-Induced Nephrotoxicity in the Rat as Assessed by Renal Glutathione Metabolism Parameters....Pages 213-217
The Urinary Excretion of Specific Proteins in Workers Exposed to Lead....Pages 218-221
Front Matter....Pages 223-223
Reduction of Arsenic Trioxide Toxicity in Mice by Repeated Treatment with Glucose....Pages 225-227
Effect of Oral Treatment with Bal, DMPS or DMSA Arsenic in Organs of Mice Injected with Arsenic Trioxide....Pages 228-230
Cyanide Antagonism in a Rodent Model....Pages 231-235
The Quantitative Determination of Cadmium in Turkish Tobacco....Pages 236-239
Modifying Role of Plasma Glucose in Acute Carbon Monoxide Poisoning....Pages 240-245
Effect of Pyrazole on Dichloromethane Metabolism to Carbon Monoxide....Pages 246-248
Ethylene Oxide Distribution in Human Blood....Pages 249-253
Distribution of Methylene Chloride in Human Blood....Pages 254-258
Acute Experimental Exposures to Acetone and Ethyl Acetate....Pages 259-262
Toxic Effects of Carbon Tetrachloride During Short and Long Term Ethanol Intake in Rats....Pages 263-265
Effects of Pyridinium,1-{[(4-Carbamoyl-Pyridinio) Methoxy] Methyl}-2-(Hydroxyimino-Methyl) Dichloride Monohydrate (HI6) and Atropine on the Circulation and Respiration of Anesthetized Guinea Pigs....Pages 266-268
The Mechanism of the Anaesthetic Action of Organic Solvents Studied with Different Membrane Models in Vitro....Pages 269-271
An in Vivo Method to Assess the Local Tolerability of Intranasally Administered Drugs....Pages 272-275
Study on the Penetration of Tetanus Toxoid Through the Nasal Mucosa....Pages 276-279
Stobadine Toxicity and Transplacental Movement....Pages 280-283
Front Matter....Pages 223-223
Some Effects of Furazolidone, Humic Acid and a Combination of Both on Male Reproduction in Rats....Pages 284-287
Residues of Carbadox Metabolites in Edible Pork Products....Pages 288-292
Pharmacological-Toxicological Investigations with a Furan Derivative Produced from Sugar-Cane on Laboratory Animals....Pages 293-297
Influence of the Degree, Position and Nature of the Halide Substitution on the Rate of Photobleaching of Xanthene Dyes....Pages 298-302
Toxicological Investigations of Waste Products from the Plasma Etching Process in the Semiconductor Industry....Pages 303-306
Sister Chromatid Exchanges in Furniture Workers Exposed to Unsaturated Polyester Resins....Pages 307-310
Acute Intoxication as a Cause of Wild Bird Mortality in the Netherlands from 1975–1989....Pages 311-315
Back Matter....Pages 317-323