Recent Advances in Retinal Degeneration

Front Matter....Pages I-XXXIV
Front Matter....Pages 1-1
Curing Blindness with Stem Cells: Hope, Reality, and Challenges....Pages 3-20
Retinal Degenerations: Planning for the Future....Pages 21-35
Front Matter....Pages 37-37
Neurotrophins Induce Neuroprotective Signaling in the Retinal Pigment Epithelial Cell by Activating the Synthesis nl of the Anti-inflammatory and Anti-apoptotic Neuroprotectin D1....Pages 39-44
On the Role of CNTF as a Pontential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde?....Pages 45-51
Nanoceria Particles Prevent ROI-Induced Blindness....Pages 53-59
An in-vivo Assay to Identify Compounds Protective Against Light Induced Apoptosis....Pages 61-67
Role of BCL-XL in Photoreceptor Survival....Pages 69-74
The Hypoxic Transcriptome of the Retina: Identification of Factors with Potential Neuroprotective Activity....Pages 75-85
Front Matter....Pages 87-87
Lentiviral Gene Transfer-Mediated Cone Vision Restoration in RPE65 Knockout Mice....Pages 89-95
In vitro Analysis of Ribozyme-mediated Knockdown of an ADRP Associated Rhodopsin Mutation....Pages 97-106
Gene Therapy for Mouse Models of ADRP....Pages 107-112
Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies....Pages 113-119
Adeno-Associated Viral Vectors and the Retina....Pages 121-128
Genetic Supplementation of RDS Alleviates a Loss-of-function Phenotype in C214S Model of Retinitis Pigmentosa....Pages 129-138
of the Retina in the 4 Years Following rAAV-mediated Gene Transfer in the RPE65 Null Mutation Dog....Pages 139-146
Virus-mediated Gene Delivery to Neuronal Progenitors....Pages 147-153
Front Matter....Pages 155-155
Loss of Visual and Retinal Function in Light-stressed Mice....Pages 157-164
ERG Responses and Microarray Analysis of Gene Expression in a Multifactorial Murine Model of Age-Related Retinal Degeneration....Pages 165-170
Oxygen Supply and Retinal Function: Insights from a Transgenic Animal Model....Pages 171-177
Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray....Pages 179-184
Front Matter....Pages 155-155
Toward a Higher Fidelity Model of AMD....Pages 185-192
The Potential of Ambient Light Restriction to Restore Function to the Degenerating P23H-3 Rat Retina....Pages 193-199
Front Matter....Pages 201-201
Mutations in Known Genes Account for 58% of Autosomal Dominant Retinitis Pigmentosa (adRP)....Pages 203-209
Genetics of Age-related Macular Degeneration....Pages 211-219
Retinal Phenotype of an X-Linked Pseudo-usher Syndrome in Association with the G173R Mutation in the RPGR Gene....Pages 221-227
Mutation in the PYK2-Binding Domain of PITPNM3 Causes Autosomal Dominant Cone Dystrophy (CORD5) in Two Swedish Families....Pages 229-234
Identification and Characterization of Genes Expressed in Cone Photoreceptors....Pages 235-244
Clinical and Genetic Characterization of a Chinese Family with CSNB1....Pages 245-252
10q26 Is Associated with Increased Risk of Age-Related Macular Degeneration in the Utah Population....Pages 253-258
Front Matter....Pages 259-259
Carboxyethylpyrrole Adducts, Age-related Macular Degeneration and Neovascularization....Pages 261-267
A Possible Impaired Signaling Mechanism in Human Retinal Pigment Epithelial Cells from Patients with Macular Degeneration....Pages 269-275
Expression and Cell Compartmentalization of EFEMP1, a Protein Associated with Malattia Leventinese ....Pages 277-282
Role of ELOVL4 in Fatty Acid Metabolism....Pages 283-290
Organization and Molecular Interactions of Retinoschisin in Photoreceptors....Pages 291-297
Front Matter....Pages 299-299
Proteomics Profiling of the Cone Photoreceptor Cell Line, 661W....Pages 301-311
γ-Secretase Regulates VEGFR-1 Signalling in Vascular Endothelium and RPE....Pages 313-319
Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells....Pages 321-326
Functional Expression of Cone Cyclic Nucleotide-Gated Channel in Cone Photoreceptor-Derived 661W Cells....Pages 327-334
Phosphorylation of Caveolin-1 in Bovine Rod Outer Segments in vitro by an Endogenous Tyrosine Kinase....Pages 335-341
Regulation of Neurotrophin Expression and Activity in the Retina....Pages 343-349
Front Matter....Pages 299-299
Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins....Pages 351-359
Rod Progenitor Cells in the Mature Zebrafish Retina....Pages 361-368
αvβ5 Integrin Receptors at the Apical Surface of the RPE: One Receptor, Two Functions....Pages 369-375
Implantation of Mouse Eyes with a Subretinal Microphotodiode Array....Pages 377-382
Variation in the Electroretinogram of C57BL/6 Substrains of Mouse....Pages 383-391
A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity....Pages 393-398
Endothelin Receptors: Do They Have a Role in Retinal Degeneration?....Pages 399-405
CNTF Negatively Regulates the Phototransduction Machinery in Rod Photoreceptors: Implication for Light-Induced Photostasis Plasticity....Pages 407-413
Back Matter....Pages 415-423