Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Front Matter....Pages i-xiv
Some Recent Advances in Leukotriene Research....Pages 1-7
Practical Aspects of Prostaglandin E 1 before and after Solid Organ Transplantation....Pages 9-12
Prostaglandins in Liver Transplantation....Pages 13-18
Prostaglandins in Heart Transplantation....Pages 19-22
Eicosanoids in Periodontal Diseases: Potential for Systemic Involvement....Pages 23-35
Mitogen-Activated Protein Kinases and Endothelial Prostacyclin Secretion....Pages 37-40
Crosstalk Between Elevation of [Ca 2+ ]i, Reactive Oxygen Species Generation and Phospholipase A 2 Stimulation in a Human Keratinocyte Cell Line....Pages 41-45
Cloning, Tissue-Specific Expression and Regulation of the Bovine Thromboxane A 2 Receptor....Pages 47-50
Weak Inhibitors of Cyclooxygenases May Exert Their Antinociceptive Effect by Modulation of Transcription Factors....Pages 51-54
New Group of Lipid Mediators Containing ω-Hydroxyarachadonic Acid (20-HETE)....Pages 55-59
Biosynthesis of Novel Divinyl Ether Oxylipins by Enzyme From Garlic ( Allium sativum L.) Bulbs....Pages 61-64
Catalytic and Spectroscopic Properties of Linoleate Diol Synthase of the Fungus Gaümannomyces graminis ....Pages 65-68
Avenoleic Acid: A New Oxylipin from Oat Seeds....Pages 69-72
Discovery of Novel Cannabinoid Receptor Ligands from Diverse Marine Organisms....Pages 73-77
Accumulation of Platelets as a Key Mechanism of Human Erection. A Scintigraphic Study in Patients with Erectile Dysfunction Receiving Intracavernous Injection of PGE 1 , Papaverine/Phentolamine....Pages 79-82
Can Self-Injection Therapy Cure Impotence?....Pages 83-86
Cytokine Levels in Five Different Fluid Compartments During Amniotic Fluid Infection and Labour....Pages 87-90
Characterization of A-93178, an Iminoxy-Quinoline....Pages 91-94
Transcellular Synthesis of CYS-LT: From Isolated Cells to Complex Organ System....Pages 95-98
Leukotriene D 4 -Induced Signalling Events in Human Epithelial Cells: Gα i3 Activation and Translocation....Pages 99-102
Interactions of Renal Cytochrome P450 (CYP), Angiotensin (AII) and Tumor Necrosis Factor-Alpha (TNF): Implications for Ion Transport....Pages 103-107
Modulation of Leukocyte-Endothelial Cell Interaction and Leukotriene Dependent Vasoconstriction by Prostacyclin Mimetics in the Isolated Rabbit Heart....Pages 109-112
Improvement of Renal Function with Selective Thromboxane A2 Synthetase Inhibitor, DP-1904 in Lupus Nephritis....Pages 113-117
Characterization of the Prostaglandin EP 3 -Receptor from Porcine Heart....Pages 119-122
Bisallylic Hydroxylation of Linoleic and Arachidonic Acids by Adult and Fetal Human Liver Microsomes and a Comparison with Human Recombinant Cytochromes P450....Pages 123-126
Organization of the Human Prostacyclin Synthase Gene and Association Analysis of a Novel CA Repeat in Essential Hypertension....Pages 127-130
Mechanism of Action of Anti-Inflammatory Drugs....Pages 131-138
Differential Effects of 2,3,7,8-Tetrachlorodibenzo- p -Dioxin on the Expression of Prostaglandin-H Synthase Isoenzymes in Mouse Tissues....Pages 139-143
In Vivo Measurement of Interstitial TXB 2 -Concentrations in Skeletal Muscle during Ischemia and Reperfusion....Pages 145-148
Mutation Of TYR-383 in Leukotriene A 4 Hydrolase: Effects on Enzyme Activities....Pages 149-152
Prostaglandin Receptors of the EP2 and EP4 Subtypes Regulate B Lymphocyte Activation and Differentiation to IGE-Secreting Cells....Pages 153-157
Urinary 9α, 11β-PGF 2 as a Marker of Mast Cell Activation in Allergic and Aspirin-Intolerant Asthma....Pages 159-162
Induction of Nitric Oxide Synthase (NOS) and Vascular Endothelial Growth Factor (VEGF) in Experimental Model of Angioplasty and Heart Ischemia....Pages 163-167
CGP57698: A Structurally Simple, Highly Potent Peptidoleukotriene (PLT) Antagonist of the Quinoline Type....Pages 169-172
S 18886, a New Thromboxane (TP)-Receptor Antagonist Is the Active Isomer of S 18204 in All Species, Except in the Guinea-Pig....Pages 173-176
Glial and Neuronal Expression of Cyclooxygenase-2: Relevance to Alzheimer’S Disease....Pages 177-180
Prostaglandin E 2 Downregulates Inducible Nitric Oxide Synthase Expression in Microglia by Increasing cAMP Levels....Pages 181-184
Formation of a Novel Class of F 3 -Isoprostanes during Peroxidation of Eicosapentaenoic Acid (EPA)....Pages 185-188
Plasma 8-Epi PGF 2α Levels in Health and Disease....Pages 189-192
Regulation of MAP-Kinase Activation by 8-Iso-Prostaglandin F 2a in Cultured Rat Aortic Smooth Muscle Cells....Pages 193-196
The Effect of Non-Prostanoid Prostacyclin Mimetics on Cyclic AMP Production by Neuronal SK-N-SH Cells....Pages 197-200
Biosynthesis of 2-Arachidonoyl-Glycerol, a Novel Cannabimimetic Eicosanoid, in Mouse Neuroblastoma Cells....Pages 201-204
Hyperalgesia-Associated Spinal Synthesis and Release of Prostaglandins....Pages 205-208
Functional Consequences of the Identification and Localisation of Cyclooxygenase Isoforms in Dorsal Horn of Rat Spinal Cord....Pages 209-212
Cyclooxygenase-2 in the Spinal Cord: Localization and Regulation after a Peripheral Inflammatory Stimulus....Pages 213-216
The Production of Biologically Active Eicosanoids by Yeasts....Pages 217-219
Is Lipoxygenation of Pathogen-Derived Arachidonic Acid Involved in Plant Protection?....Pages 221-226
The Production of Eicosanoid Precursors by Mucoralean Fungi....Pages 227-229
Biotransformation of Arachidonic Acid and Other Eicosanoids by the Yeast Dipodascopsis uninucleata , the Oomycete Fungi Saprolegnia diclina and Leptomitus lacteus and the Zygomycete Fungus Mortierella isabellina ....Pages 231-234
Human Prostacyclin Receptor: Cloning and Co-Expression with EP3 Prostaglandin Receptor....Pages 235-238
Three Isoforms of the Prostaglandin E Receptor EP3 Subtype Different in Agonist-Independent Constitutive Gi Activity and Agonist-Dependent Gs Activity....Pages 239-242
Neurogenic Inhibitory Action Through Platelets of Platelet Activating Factor (PAF) on Vasoconstrictive Responsiveness to Pressor Agents....Pages 243-247
High and Low Affinity Mutants of Platelet-Activating Factor Receptor....Pages 249-253
Differential Effect of Corticotropin Releasing Factor on Interleukin-1α and Interleukin-1β-Induced Prostaglandin Synthesis in Endothelial Cells and Fibroblasts....Pages 255-258
Brain and Peripheral Anandamide Amidohydrolase and Its Inhibition by Synthetic Arachidonate Analogues....Pages 259-263
Effects of 13-HODE and Other Momohydroxides on Integrin/Ligand Binding: Implications for Cell Cell Interactions....Pages 265-269
Effect of Linoleic Acid Supplements on Vessel Wall Hyperplasia in Rabbits....Pages 271-274
Effects of Linoleic Acid and/or Marine Fish Oil Supplements on Vessel Wall Thromboresistance in Patients Undergoing Cardiac Surgery....Pages 275-278
13-Hydroxyoctadecadienoic Acid Reverses Epidermal Hyperproliferation via Selective Inhibition of Membrane Protein Kinase C-β Activity....Pages 279-283
Effects of Linoleic Acid Supplements on Atopic Dermatitis....Pages 285-289
The Importance of Linoleic Acid Metabolites in Cancer Metastasis and in the Synthesis and Actions of 13-HODE....Pages 291-294
The Role of Prostaglandins and Nitric Oxide in the Response of Bone to Mechanical Stimulation....Pages 295-298
Mice Lacking 5-Lipoxygenase Have Increased Cortical Bone Thickness....Pages 299-302
Parathyroid Hormone Induction of Cyclooxygenase-2 Expression in Human Osteoblasts Depends on Both Cyclic AMP and Calcium-Dependent Pathways....Pages 303-306
Involvement of Prostaglandin Endoperoxide H Synthase-2 in Osteoclast Formation Induced by Parathyroid Hormone....Pages 307-309
Mechanotransduction in Bone Cells: Induction of Nitric Oxide and Prostaglandin Synthesis by Fluid Shear Stress, but Not by Mechanical Strain....Pages 311-314
Histamine Potentiates Leukotriene B 4 -Induced Leukocyte Adhesion: A Potential Role of Histamine 1 -Receptor Antagonism in Allergic Leukocyte Recruitment....Pages 315-318
Gastric Prostacyclin (PGI 2 ) Prevents Stress-Induced Gastric Mucosal Injury in Rats by Inhibiting Leukocyte Activation....Pages 319-322
Anti-P-Selectin Antibody Exacerbated Inflammatory Responses in Acetic Acid-Induced Colitis....Pages 323-326
Heterogeneous Distribution of COX-2 Over-Expression in Human Colon Carcinoma Cells....Pages 327-330
HSP70: A Subunit of the Cytosolic 12(S)-HETE Binding Complex....Pages 331-338
Apoptosis Induction and Inhibition of Colon-26 Tumour Growth and Angiogenesis: Findings On COX-1 and COX-2 Inhibitors in Vitro & in Vivo and Topical Diclofenac in Hyaluronan....Pages 339-342
Phospholipase A 2 Inhibitory Activity in Lung Cancer Cell Lines....Pages 343-345
Prostaglandin D Synthase, β-Trace and Sleep....Pages 347-350
Human Beta-Trace in Normal and Pathological CNS Tissues, Genital Organs and Body Fluids....Pages 351-354
Effect of Immunization with β-Trace Protein on Testosterone Levels in Animals....Pages 355-358
Eicosanoids Mediate Insect Cellular Immune Reactions to Bacterial Infections....Pages 359-362
Arachidonic Acid and Eicosanoids in Hydra : Possible Endogenous Signals Involved in Chemoreception and Modulation of the Feeding Behaviour....Pages 363-366
Synthesis and Action of Eicosanoids in Warm and Cold-Acclimated Amphibians....Pages 367-370
Molecular and Catalytic Properties of Mammalian Lipoxygenases Compared with Soybean Lipoxygenase-1....Pages 371-374
Leukotriene A 4 Hydrolase Activity in Xenopus laevis ....Pages 375-378
Monocyte Binding to Endothelial Cells Induced by Oxidized Phospholipids Present in Minimally Oxidized Low Density Lipoprotein Is Inhibited by a Platelet Activating Factor Receptor Antagonist....Pages 379-382
Regulation of 5-Lipoxygenase Activity by Selenium-Dependent Peroxidases - Effects of Transforming Growth Factor-Beta and 1,25-Dihydroxyvitamin D 3 ....Pages 383-386
Thromboxane A 2 Potentiates Thrombin-Induced Proliferation of Coronary Artery Smooth Muscle Cells....Pages 387-390
Isoforms of Type-I 15-Hydroxyprostaglandin Dehydrogenase mRNA....Pages 391-394
Keratinocyte Growth Factor Increases LTC 4 Synthesis and Expression of Flap in Cultured Rat Alveolar Type II Cells....Pages 395-398
Type-I 15-Hydroxyprostaglandin Dehydrogenase: Role in Macrophage/Osteoclast Differentiation....Pages 399-402
PGE 2 and TXA 2 Production by Isolated Macrophages from Human Placenta....Pages 403-406
Intrauterine Eicosanoid Production in Uncomplicated and Hypertensive Pregnancies: Alterations of Placental 12-Hydroxyeicosatetraenoic Acid....Pages 407-410
Formation of Cytochrome P450 Metabolites of Arachidonic Acid by Human Placenta....Pages 411-413
Prostaglandin Endoperoxide H Synthase-2 Expression in Human Amnion Cells: Involvement of Tyrosine Kinases in the Regulation....Pages 415-418
Prostaglandin E 2 Production by Endogenous Secretion of Interleukin-1 in Decidual Cells from Term Fetal Membrane....Pages 419-422
The Development of a Highly Specific, Sensitive Enzyme Immunoassay for Prostaglandin E 1 ....Pages 423-426
The Use of Chemiluminescence to Detect Eicosanoids with Greater Speed and Sensitivity....Pages 427-430
Vascular Wall-Rather Than Platelet PGE 1 -Pretreatment in-Vivo (but Not in-Vitro) Decreases Thrombogenicity....Pages 431-434
A Model of Arachidonic Acid Binding for 15-Lipoxygenase....Pages 435-438
Changes in Kinetic Properties of Cytosolic Phospholipase A 2 in Activated Rat Neutrophils....Pages 439-442
Stimulation of PGI 2 - Synthesis in the Periodontal Tissue by Interleukin-1α and -1β....Pages 443-446
Activation of Cardiac EP 3 Receptors by PGE 1 Reduces β-Adrenergic Inotropic Effects....Pages 447-450
Back Matter....Pages 451-454