Purines: Pharmacology and Physiological Roles

Front Matter....Pages i-xix
Summary of a Symposium Discussion on Purine Receptor Nomenclature....Pages 1-4
Adenosine Receptors in the Central Nervous System: Structure-Activity Relationships for Agonists and Antagonists....Pages 5-15
Characterization of Adenosine Receptors in the Hippocampus and Other Regions of Rat Brain....Pages 17-26
Behavioral Actions of Adenosine Analogues....Pages 27-44
The Pharmacology of Purines in the CNS: Interactions with Psychoactive Agents....Pages 45-56
Actions of Purines in Autonomic Ganglia....Pages 57-66
Processes by which Purines Inhibit Transmitter Release....Pages 67-73
Are there two Types of Adenosine Receptors in Peripheral Tissues?....Pages 75-84
Structure-Activity Relationship Studies of Adenosine Analogs in Peripheral Tissues: Implications for Receptor Classification and Structure....Pages 85-94
Release of ATP from Central and Peripheral Nerve Terminals....Pages 95-105
Metabolism and Release of Purines from Nervous Tissue....Pages 107-114
Uptake of ATP by Tissues....Pages 115-124
Adenosine and the Cardiovascular System: Some of the Problems and Controversies....Pages 125-130
Metabolic Regulation of Cerebral Blood Flow by Adenosine....Pages 131-141
Purines and Hypertension....Pages 143-151
Purines and Hypertension: Interaction with Hydralazine....Pages 153-162
Actions and Structure-Activity Relationships of Purines on Platelets....Pages 163-173
Adenosine as a Putative Mediator in Asthma: Its Role in Bronchoconstriction and Modulation of Histamine Release from Human Lung Mast Cells and Basophil Leucocytes....Pages 175-184
Modulation of Adenylate Cyclase by Physiological and Pharmacological Manipulation of the Prevalent Adenosine Concentration....Pages 185-192
Ligand Binding to Adenosine Receptors and the Inhibition of Adenylate Cyclase....Pages 193-202
Magnesium Ions Exert a Central Role in Integrating Adenosine Receptor Occupancy with the Inhibition of Adenylate Cyclase....Pages 203-214
The Endogenously Formed Adenosine of the Brain: Its Status as a Regulatory Signal Appraised in Relation to Actions of Homocystein....Pages 215-221
Regulation of Lipolysis and Circulation in Adipose Tissue....Pages 223-232
Effects of Purines on Cell Growth and Differentiation....Pages 233-243
Some Unresolved Problems....Pages 245-251
Poster Abstracts....Pages 253-277
Back Matter....Pages 279-284