Purines and Myocardial Protection

Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Physiologic and Pathophysiologic Significance of Purine Metabolism in the Heart....Pages 3-16
Purine Metabolism in the Ischemic Canine and Human Immature Myocardium Deficient of 5’-Nucleotidase....Pages 17-37
Cardiac Adenosine Metabolism: Physiological Implications....Pages 39-53
Purine Metabolism in Human Cardiomyocytes and Endothelium — Implications for Protection of the Heart During Cardiac Surgery....Pages 55-80
Assessment of Interstitial Fluid Adenosine: Implications for Exogenous and Endogenous Adenosine-Mediated Cardioprotection....Pages 81-94
Adenosine and Coronary Vascular Pharmacology....Pages 95-104
Alterations in Energy Substrate Metabolism During Oxidative Stress....Pages 105-116
Front Matter....Pages 117-117
Purines and Myocardial Protection: An Overview....Pages 119-148
Nucleoside Transport Protein: Properties and Regulation....Pages 151-163
Role of Nucleoside Transport in Myocardial Injury and Protection: Separation Between Ischemic and Reperfusion Injury Using a Selective Nucleoside Transport Blocker, p -Nitrobenzylthioinosine, NBMPR....Pages 165-181
Myocardial Protection Using Nucleoside Transport Inhibitors....Pages 183-195
Selective Blockade of Nucleoside Transport by NBMPR Attenuates Reperfusion-Mediated Ventricular Arrhythmias....Pages 197-208
Nucleoside Transport in the Human Myocardium....Pages 209-218
Selective Nucleoside Transport Blocker NBMPR Attenuates Myocardial Stunning in a Rabbit Model Deficient of Xanthine Oxidase....Pages 219-230
Amplification of Endogenous Adenosine by “Adenosine Regulating Agents” as a Therapeutic Approach to the Treatment of Cardiac Ischemic Syndromes....Pages 231-258
Organ Protection with ATP-Magnesium Chloride....Pages 261-284
Adenosine and Adenosine Receptor Protection of the Ischemic Heart....Pages 285-295
Effect of Adenosine on Myocardial Stunning....Pages 297-313
Cardioprotection from Ischemic-Reperfusion Injury by Adenosine....Pages 315-344
Cardioprotection with Adenosine, Inosine and Hypoxanthine....Pages 345-358
Front Matter....Pages 117-117
Adenosine and Adrenergic Mediated Effects in the Heart....Pages 359-371
Effects of Adenosine on Ventricular Tachycardia....Pages 373-382
Purines and Ventricular Arrhythmias....Pages 383-394
Adenosine and the Polymorphonuclear Leukocyte Function, Mechanisms and Production....Pages 395-407
Purines and Regulation of Platelet Activation....Pages 409-418
Front Matter....Pages 419-419
Myocardial Preconditioning: From a Model to a Phenomenon....Pages 421-431
ATP Metabolism and Ischemic Preconditioning....Pages 433-445
Do Adenosine A 3 Receptors Cause Preconditioning?....Pages 447-458
K ATP Channels, Adenosine Receptors and Ischemic Preconditioning....Pages 459-467
Role of Activation of Ecto-5’-Nucleotidase for Cardioprotection in Ischemic and Reperfusion Injury: Role of Purine and Adenosine Metabolism....Pages 469-480
Ischemic Preconditioning in a Model of Isolated Cardiomyocytes....Pages 481-497
Integration of Adenosine and Noradrenergic Pathways in Cardiac Preconditioning....Pages 499-512
Myocardial Stunning and Preconditioning During Non-Cardioplegic Warm Intermittent Aortic Cross-Clamping....Pages 513-523
Front Matter....Pages 525-525
Energy and Cation Control in the Reoxygenated Myocardial Cell....Pages 527-536
Cytosolic Calcium Transport During Myocardial Protection....Pages 537-552
Future Therapeutic Use of Purines in Myocardial Protection....Pages 553-561
Back Matter....Pages 563-564