Purine Metabolism in Man-III: Clinical and Therapeutic Aspects

Front Matter....Pages i-xxii
The Natural History of Hyperuricemia Among Asymptomatic Relatives of Patients with Gout....Pages 1-7
The Clinical Differentiation of Primary Gout from Primary Renal Disease in Patients with Both Gout and Renal Disease....Pages 9-13
Renal Failure in Young Subjects with Familial Gout....Pages 15-20
Family Study of Lipid and Purine Levels in Gout Patients and Analysis of Mortality....Pages 21-26
Uric Acid Turnover in Normals, in Gout and in Chronic Renal Failure Using 14 C-Uric Acid....Pages 27-31
Erythrocyte Adenosine-Deaminase Activity in Gout and Hyperuricemia....Pages 33-38
Clinical Variability of the Gouty Diathesis....Pages 39-46
Clinical Features of 4,000 Gouty Subjects in Japan....Pages 47-54
Frequency of Chondrocalcinosis of the Knees and Avascular Necrosis of the Femoral Heads in Gout, a Controlled Study....Pages 55-58
Gas-Chromatographic Evaluation of Urinary 17-Ketosteroids, Etiocholanolone and Dehydroepiandrosterone in Primary Gout and Hyperuricemia....Pages 59-63
Hormonal Aspects of Gouty Patients....Pages 65-71
Determination of Tubular Secretion of Urate in Healthy and Gouty Men....Pages 73-79
Ribose Tolerance in Gouty Patients....Pages 81-86
Urinary Urate and Uric Acid Relative Saturation in Normouricuric Calcium Oxalate Stone Formers with Normal Urinary Calcium Oxalate Saturation....Pages 87-92
Correlation between the Uric Acid and Calcium Concentration in Urine. Results of a Long Term Study on Recurrent Stone-Formers and Healthy Controls....Pages 93-98
Interaction of Hyperuricuria and Hyperoxaluria on Renal Calcium Oxalate Stone Formation....Pages 99-107
Uric Acid/Calcium Oxalate Nephrolithiasis. Clinical and Biochemical Findings in 86 Patients....Pages 109-113
The Uric Acid: Cystine Correlation in the Urine of Recurrent Calcium Oxalate Stone-Formers and Healthy Controls....Pages 115-119
The Role of Urate in Idiopathic Calcium Urolithiasis....Pages 121-127
Mineralogic Composition of 66 Mixed Urinary Calculi of Calcium Oxalate and Uric Acid....Pages 129-133
Hyperuricemia and Cystinuria....Pages 135-139
Monosodium Urate Monohydrate as Spherulites....Pages 141-143
Tumoural Hypouricemia....Pages 145-148
Hereditary Renal Hypouricemia with Hyperuricosuria and Variably Absorptive Hypercalciuria and Urolithiasis — A New Syndrome....Pages 149-153
Hereditary and Environmental Factors Influencing on the Serum Uric Acid Throughout Ten Years Population Study in Japan....Pages 155-159
The Natural History of Urate Overproduction in Sickle Cell Anemia....Pages 161-165
Salvage Pathway in Erythrocytes of Patients with Psoriasis....Pages 167-171
Serum 5-Nucleotidase in Progressive Muscular Dystrophy....Pages 173-176
Purine Metabolism in Duchenne Muscular Dystrophy....Pages 177-182
Metabolism of Adenine and Adenosine in Erythrocytes of Patients with Myotonic Muscular Dystrophy (MMD)....Pages 183-188
Clinical and Enzymological Studies in a Child with Type I Glycogen Storage Disease Associated with Partial Deficiency of Hepatic Glucose-6-Phosphatase....Pages 189-202
Differential Absorption of Purine Nucleotides, Nucleosides and Bases....Pages 203-208
Influence of Dietary Protein on Serum and Urinary Uric Acid....Pages 209-213
Effect of Hypoxanthine in Meat on Serum Uric Acid and Urinary Uric Acid Excretion....Pages 215-219
On the Mechanism of the Paradoxical Effect of Salicylate on Urate Excretion....Pages 221-225
The Uricosuric Action of Protein in Man....Pages 227-231
Hypoxic Effects on Purine Metabolism Studied with High Pressure Liquid Chromatography....Pages 233-236
Urate Metabolism in a Mongrel Dog....Pages 237-240
The Effect of Weight Reduction on Plasma and Urinary Levels of Oxypurines in an Obese Xanthinuric Patient....Pages 241-246
Xanthinuria: The Cause of Hypouricemia in Hepatic Disease....Pages 247-250
Xanthine-Coproporphyrin III....Pages 251-255
A Controlled Study of the Effect of Long Term Allopurinol Treatment on Renal Function in Gout....Pages 257-262
Studies with Allopurinol in Patients with Impaired Renal Function....Pages 263-267
Pharmacological Effects of 1,3,5-Triazines and Their Excretion Characteristics in the Rat....Pages 269-276
Tienilic Acid in the Treatment of Gout and Hypertension....Pages 277-282
Benzbromarone as a Long-Term Uricosuric Agent....Pages 283-286
The Action of Benzbromarone in Relation to Age, Sex and Accompanying Diseases....Pages 287-294
Covalitin® a New Drug for the Treatment of Uric Lithiasis....Pages 295-300
Hypoxanthine Salvage in Man: Its Importance in Urate Overproduction in the Lesch-Nyhan Syndrome....Pages 301-306
Aspect of Purine Metabolic Aberration Associated with Uric Acid Overproduction and Gout....Pages 307-312
Properties of a Mutant Hypoxanthine-Phosphoribosyltransferase in a Patient with Gout....Pages 313-316
Variation in Human HPRT and Its Relationship to Neurologic and Behavioral Manifestations....Pages 317-325
High HPRT Activity in Fibroblasts from Patients with Lesch-Nyhan Syndrome Due to Bacterial “L-Form” Contamination....Pages 327-331
Kinetics of a HGPRT Mutant Showing Substrate Inhibition....Pages 333-336
Spectrum of 2,8-Dihydroxyadenine Urolithiasis in Complete APRT Deficiency....Pages 337-341
Complete Adenine Phosphoribosyltransferase (APRT) Deficiency in Two Siblings: Report of a New Case....Pages 343-348
Inheritance of Adenine Phosphoribosyltransferase (APRT) Deficiency....Pages 349-353
Immunological Evaluation of a Family Deficient in Adenine Phosphoribosyl Transferase (APRT)....Pages 355-359
Activities of Amidophosphoribosyltransferase and Purine Phosphoribosyltransferases in Developing Rat Brain....Pages 361-366
Purine Nucleoside Phosphorylase Deficiency; Genetic Studies in a Dutch Family....Pages 367-373
Abnormal Regulation of Purine Metabolism in a Cultured Mouse T-Cell Lymphoma Mutant Partially Deficient in Adenylosuccinate Synthetase....Pages 375-386
Superactive Phosphoribosylpyrophosphate Synthetase with Altered Regulatory and Catalytic Properties....Pages 387-392
AMP Phosphatase Activity in Human Term Placenta: Studies on Placental 5′-Nucleotidase....Pages 393-395
Adenosine and Deoxyadenosine Metabolism in the Erythrocytes of a Patient with Adenosine Deaminase Deficiency....Pages 397-401
Complete Adenosine Deaminase (ADA) Deficiency without Immunodeficiency, and Primary Hyperoxaluria, in a 12-Year-Old Boy....Pages 403-408
Metabolism of Adenosine and Deoxyadenosine by Stored Human Red Cells....Pages 409-414
Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities during Culturing of Fibrolasts....Pages 415-420
S-Adenosylhomocysteine Metabolism in Adenosine Deaminase Deficient Cells....Pages 421-425
Altered Deoxynucleoside Triphosphate Levels Paralleling Deoxyadenosine Toxicity in Adenosine Deaminase Inhibited Human Lymphocytes....Pages 427-431
Back Matter....Pages 433-444