Purine Metabolism in Man—III: Biochemical, Immunological, and Cancer Research

Front Matter....Pages i-xxii
De Novo Purine Synthesis in Cultured Human Fibroblasts....Pages 1-6
Comparative Metabolism of a New Antileishmanial Agent, Allopurinol Riboside, in the Parasite and the Host Cell....Pages 7-12
Purine Metabolism in Rat Skeletal Muscle....Pages 13-17
Alterations in Purine Metabolism in Cultured Fibroblasts with HGPRT Deficiency and with PRPP Synthetase Superactivity....Pages 19-24
Purine Metabolism in Cultured Coronary Endothelial Cells....Pages 25-30
Determinants of 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthesis in Human Fibroblasts....Pages 31-34
Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism....Pages 35-40
Human Placental Adenosine Kinase: Purification and Characterization....Pages 41-43
Long-Term Effects of Ribose on Adenine Nucleotide Metabolism in Isoproterenol-Stimulated Hearts....Pages 45-50
Purine Salvage Enzymes in Man and Leishmania donovani ....Pages 51-56
Regulation of Purine Savage Enzymes in E. coli ....Pages 57-60
Purine Transport and the Cell Cycle....Pages 61-67
Hypoxanthine Transport in Human Erythrocytes....Pages 69-72
Uptake of Adenosine in Human Erythrocytes....Pages 73-78
Effect of Actinomycin D on in vivo Purine Biosynthesis in Hamster Cells....Pages 79-84
Purine Catabolism in Isolated Hepatocytes : Influence of Coformycin....Pages 85-86
Inactivation of Hypoxanthine Guanine Phosphoribosyltransferase by Guanosine Dialdehyde : An Active Site Directed Inhibitor....Pages 87-91
Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion....Pages 93-101
Purification and Characterization of Mammalian Adenine Phosphoribosyltransferases....Pages 103-109
The Effect of Phosphoribosylpyrophosphate on Stability and Configuration of Hypoxanthineguaninephosphoribosyltransferase and Adeninephosphoribosyltransferase from Human Erythrocytes....Pages 111-115
Radioimmunochemical Analysis of Human Erythrocyte Adenosine Deaminase....Pages 157-162
Adenosine Deaminase Conversion Proteins: A Potential Role....Pages 163-168
Regulatory Properties of AMP Deaminase Isozymes....Pages 169-175
Human Adenosine Deaminase: Stoichiometry of the Large form Complex....Pages 177-181
Guanase from Human Liver — Purification and Characterisation....Pages 183-188
Nicotinamide and Liver Xanthine Oxdidase....Pages 189-196
Xanthine Oxidase Activity in Human Intestines. Histochemical and Radiochemical Study....Pages 197-201
Chemical Modification of Hypoxanthine-Phosphoribosyltransferase and Its Protection by Substrates and Products....Pages 117-122
Structural Studies of Human Adenine Phosphoribosyltransferase Purified by Affinity Chromatography....Pages 123-129
Phosphoribosylpyrophosphate (PRPP) Synthetase Mutant in Salmonella typhimurium ....Pages 131-136
Methylmercaptopurine Ribonucleoside Toxicity in Human Fibroblasts: Inhibition of Phosphoribosylpyrophosphate Synthetase as Well as Amidophosphoribosyltransferase....Pages 137-143
Adenosine Kinase: Regulation by Substrates, Magnesium and pH....Pages 145-149
Adenosine and Deoxyadenosine Kinase from Rat Liver....Pages 151-156
Purine and Pyrimidine Metabolism in Hereditary Oroticaciduria During a 15 Year Follow-Up Study....Pages 203-208
Effect of Allopurinol on Pyrimidine Metabolism in Human White Blood Cells. Role of the Salvage Pathway....Pages 209-215
Kinetics and Compartmentation of Erythrocyte Pyrimidine Metabolism....Pages 217-222
Simultaneous Determination of Rates of Purine and Pyrimidine Synthesis in Cultured Human Lymphoblasts and Fibroblasts....Pages 223-229
Activities of Enzymes of Purine and Pyrimidine Metabolism in Nine Mycoplasma Species....Pages 231-235
Increases in Purine Excretion and Rate of Synthesis by Drugs Inhibiting IMP Dehydrogenase or Adenylosuccinate Synthetase Activities....Pages 237-241
Possible Role for 5′-Nucleotidase in Deoxyadenosine Selective Toxicity to Cultured Human Lymphoblasts....Pages 243-250
Cyclic Nucleotide Levels and Mechanism of Inhibition of Leucocyte Function by Adenosine Deaminase Inhibition....Pages 251-257
Purine Ribonucleoside and Deoxyribonucleoside Metabolism in Thymocytes....Pages 259-264
Molecular Mechanism(s) of Deoxyribonucleoside Toxicity in T-Lymphoblasts....Pages 265-270
Inhibition of Immune Cell Function by Adenosine: Biochemical Studies....Pages 271-276
Interactions between Energy Metabolism and Adenine Nucleotide Metabolism in Human Lymphoblasts....Pages 277-282
Enzymes of Purine Interconversions in Subfractions of Lymphocytes....Pages 283-288
Measurement of the Rates of Synthesis and Degradation of Hypoxanthine-Guanine Phosphoribosyltransferase in Human Lymphoblasts....Pages 289-294
Human 5′-nucleotidase. Properties and Characterization of the Enzyme from Placenta, Lymphocytes and Lymphoblastoid Cells in Culture....Pages 295-298
Metabolism and Toxicity of 9-β-D-Arabinofuranosyladenine in Human Malignant T Cells and B Cells in Tissue Culture....Pages 299-307
Suppression of Cellular Immunity due to Inhibition of Purine Nucleoside Phosphorylase by Allopurinol-Riboside....Pages 309-313
Lymphocyte 5′-Nucleotidase Deficiency: Clinical and Metabolic Characteristics of the Associated Hypogammaglobulinemia....Pages 315-320
Immunological Studies on Lesch-Nyhan Patients....Pages 321-326
Activity of Ecto-5′-Nucleotidase in Lymphoblastoid Cell Lines Derived from Carriers of Congenital X-Linked Agammaglobulinemia....Pages 327-332
Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia....Pages 333-337
Purine Salvage Enzymes in Lymphocytes and Granulocytes from Patients with Small-Cell Carcinoma of the Lung....Pages 339-345
Treatment of Acute Lymphoblastic Leukemia with the Adenosine Deaminase Inhibitor 2′-Deoxycoformycin....Pages 347-350
Increase of Phosphoribosylpyrophosphate Levels in Cultured L1210 Leukemia Cells Exposed to Methotrexate....Pages 351-356
Purine Salvage Pathway in Leukemic Cells....Pages 357-363
Biochemical Consequences of Treatment with the Adenosine Deaminase Inhibitor 2′-Deoxycoformycin....Pages 365-371
In Vitro and in Vivo Effect of Deoxycoformycin in Human T Cell Leukemia....Pages 373-379
Uniqueness of Deoxyribonucleotide Metabolism in Human Malignant T Cell Lines....Pages 381-388
High Performance Liquid Chromatography of Plasma Pyrimidines and Purines and Its Application in Cancer Chemotherapy....Pages 389-394
Urate-Binding Proteins in Plasma Studied by Affinity Chromatography....Pages 395-399
Chromatographic Determination of PRPP-Synthetase Activity in Human Blood Cells....Pages 401-407
Purification of Myocardial Adenosine Kinase Using Affinity and Ion-Exchange Chromatography....Pages 409-414
Micromethods for the Measurement of Purine Enzymes in Lymphocytes....Pages 415-420
A Rapid Screening Method for Inborn Errors of Purine and Pyrimidine Metabolism Using Isotachophoresis....Pages 421-427
Analysis of Serum Purines and Pyrimidines by Isotachophoresis....Pages 429-433
Determination of Uric Acid in Serum: Comparison of a Standard Enzymatic Method and Isotachophoresis....Pages 435-440
Addition Products of Uric Acid and Formaldehyde....Pages 441-443
Automated Retrieval of Purine Literature....Pages 445-447
Back Matter....Pages 449-459