Purine and Pyrimidine Metabolism in Man X

Purine and Pyrimidine Metabolism Between Millennia: What has been Accomplished, What has to be Done?....Pages 1-4
Cell Type-Specific Differential Expression of Human PRPP Synthetase (PRPS) Genes....Pages 5-10
Mutations in the Hypoxanthine-Guanine Phosphoribosyltransferase Gene in Spanish HPRT Deficient Families....Pages 11-14
The Spectrum of Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) Deficiency....Pages 15-21
Deletion in the Hypoxanthine Phosphoribosyltransferase Gene Caused by Alu-Alu Recombination in Two Japanese Patients With Lesch-Nyhan Syndrome....Pages 23-27
Novel Genetic Mutations Responsible for the HPRT Deficiency and the Clinical Phenotypes in Japanese....Pages 29-33
Adenoviruses Encoding HPRT Correct the Biochemical Abnormalities Fully Only in HPRT-Deficient Human Cell Lines: Importance of Species Differences....Pages 35-40
Biochemical and Immunological Abnormalities in Purine Nucleoside Phosphorylase Deficient Mice....Pages 41-45
Carrier Erythrocyte Entrapped Adenosine Deaminase Therapy in Adenosine Deaminase Deficiency....Pages 47-50
ADA Activity and dATP Levels in Erythrocytes after Bone Marrow Transplantation....Pages 51-55
Adenosine Deaminase-Deficient Mice: Models for the Study of Lymphocyte Development and Adenosine Signaling....Pages 57-63
Inhibition of Fetal Thymic Caspases Abrogates the Consequences of Adenosine Deaminase Deficiency....Pages 65-70
Erythrocyte AMP Deaminase Deficiency in Japanese: A Compound Heterozygote Responsible for the Complete Deficiency....Pages 71-74
Effect of Uridine Administration to a Patient with Adenylosuccinate Lyase Deficiency....Pages 75-78
Adenylosuccinate Lyase Deficiency: From the Clinics to Molecular Biology....Pages 79-82
Polymorphic Markers in the XDH Gene as Diagnostic Tools for Typing Classical Xanthinuria....Pages 83-86
NAPDD Patients Exhibit Altered Electrophoretic Mobility of Cytosolic 5′ Nucleotidase....Pages 87-90
Purines, Lactate and Myo-Inositol in CSF Might Reflect Excitotoxicity in Inherited Metabolic Disorders....Pages 91-95
Cerebrospinal Fluid Purines, Pyrimidines, Organic Acids and Amino Acids in Neonatal Citrullinaemia....Pages 97-101
Purine Nucleotide Catabolism in Rat Liver....Pages 103-106
Further Refinement on the Engineering of Adenosine Phosphorylase from Purine Nucleoside Phosphorylase....Pages 107-110
Human Guanine Deaminase: Cloning, Expression and Characterisation....Pages 111-114
The Human NUDT Family of Nucleotide Hydrolases....Pages 115-118
Inhibitors of NTPDase: Key Players in the Metabolism of Extracellular Purines....Pages 119-123
Apoptosis-Inducing Cleavage of Caspases by Trimidox, an Inhibitor of Ribonucleotide Reductase....Pages 125-130
Increased Visceral Fat Accumulation in Patients with Primary Gout....Pages 131-134
Serum Uric Acid Levels and Microalbuminuria in Mild Hypertensive Patients....Pages 135-137
Guanosine-5′-Triphosphate Increases in Red Blood Cells of Heart Transplant Recipients Treated with Mycophenolate Mofetil....Pages 139-143
Adenine Incorporation in Endothelial Cells....Pages 145-148
TNF-□ Reduces the Activity of Ecto-5′-Nucleotidase in Human Endothelial Cells....Pages 149-152
Influence of Age and Heat Stress on Cardiac Function and Nucleotide Levels....Pages 153-157
The Role of 5′ -Deoxy-5′-Methyl Thioadenosine Phosphorylase in Cardiac Adenosine Breakdown and Adenine Production....Pages 159-162
The Effect of Adenosine Metabolism Inhibition and Nucleotide Precursor Supply on Adenosine Production in Human Heart Endothelial Cells....Pages 163-166
Enhanced Endogenous Adenosine Production and Protection of the Heart after Transplantation....Pages 167-170
Role of Bovine Hemoglobin Enriched Cardioplegia in Myocardial Preservation....Pages 171-174
Identification of the Potential Sensitive Urate/PAH Transporter from LLC-PK 1 Kidney Epithelial Cells....Pages 175-178
Genomic Structure of Galectin-9 Gene....Pages 179-183
Effect of Losartan and Furosemide on the Urinary Excretion of Oxypurinol and Uric Acid....Pages 185-188
P2Y and P2X Purinoceptors are Respectively Implicated in Endothelium- Dependent Relaxation and Eedothelium Independent Contraction in Human Corpus Cavernosum....Pages 189-195
ATP-Triggered Calcium Signals in Human Neutrophils....Pages 197-200
The Role of A1/A3 Adenosine Receptor Activation in Reduction of Cardiomyocyte Injury Caused by Hypoxic Stress and in Induction of Apoptosis in Rat Cardiomyocyte Cultures....Pages 201-205
Blockade of A 1 Receptors by Caffeine Induces C- fos , Zif -268 and ARC Expression in the Striatum Through Different Interactions with the Dopamine System....Pages 207-216
Role of K ATP Channels in the Induction of Ischemic Tolerance by the ‘Adenosine Mechanism’ Neuronal Cultures....Pages 217-221
Adenosine-Induced Caspase Activity in N1E-115 Cells....Pages 223-226
Effect of Adenosine Receptor Agonists and Antagonists on Transport of Adenosine in Bovine Heart Microvascular Endothelial Cells....Pages 227-231
Defects of Pyrimidine Degradation: Clinical, Molecular and Diagnostic Aspects....Pages 233-241
Confirmation of the Enzyme Defect in the First Case of β-Ureidopropionase Deficiency....Pages 243-245
Dihydropyrimidine Dehydrogenase (DPD) Deficiency: Novel Mutations in the DPD Gene....Pages 247-250
Dihydropyrimidine Dehydrogenase Deficiency and 5-Fluorouracil Associated Toxicity....Pages 251-255
Isoforms of Human CTP Synthetase....Pages 257-261
Polyclonal Antibodies Against the Ultrafast Multisubstrate Deoxyribonucleoside Kinase from Drosophila Melanogaster....Pages 263-266
Inhibition and Localization of Human and Rat Dihydroorotate Dehydrogenase....Pages 267-270
6-Mercaptopurine: Efficacy and Bone Marrow Toxicity in Childhood Acute Lymphoblastic Leukemia....Pages 271-275
Recovery of SK-N-Be(2)C Cells from Treatmemt with Cyclopentenyl Cytosine....Pages 277-280
Effect of Phosphorylation on Deoxycytidine Kinase Activity....Pages 281-285
The Role of Deoxycytidine Kinase in Gemcitabine Cytotoxicity....Pages 287-290
Thymidine Phosphorylase in Angiogenesis and Drug Resistance....Pages 291-294
Secretion of Thymidine by Hybridoma Cells....Pages 295-301
Thymidylate Synthase Inhibition Induces P53 Dependent and Independent Cell Death....Pages 303-306
2-Chlorodeoxyadenosine (2-CDA) does not Change the Expression of Fas Antigen on Chronic Lymphocytic Leukaemia Cells....Pages 307-310
Cyclopentenyl Cytosine Increases the Phosphorylation and Incorporation into DNA of Arabinofu-Ranosyl Cytosine in a Myeloid Leukemic Cell-Line....Pages 311-317
Cyclopentenyl Cytosine Induces Apoptosis and Secondary Necrosis in a T-Lymphoblastic Leukemic Cell-Line....Pages 319-325
Thiopurine Methyl Transferase: Activity and Genotyping in Patients with Acute Lymphoblastic Leukemia....Pages 327-331
Hyperthermy Increase the Phosphorylation of Deoxycytidine in the Membrane Phospholipid Precursors and Decrease its Incorporation into DNA....Pages 333-337
Purine Nucleotide Metabolism in Chronic Lymphocytic Leukemia Lymphocytes....Pages 339-342
Inhibition of DNA Methylation by 5-Aza-2′-Deoxycytidine Correlates with Induction of K562 Cells Differentiation....Pages 343-347
Evidence of Inhibition of DNA Methylation by Fludarabine....Pages 349-353
The Cytotoxic Effect of Purine Riboside on COS-7 Cells....Pages 355-359
Methylated and Non Methylated Thiopurine Nucleotide Ratio (ME6-MPN/6-TGN): Usefulness in the Monitoring of Azathioprine Therapy?....Pages 361-367
Organ Preservation During Experimental Liver Transplantation....Pages 369-372
Extraction and Purification of Ecto-5′-Nucleotidase from Human Lymphocytes....Pages 373-376
HPLC/ESI Tandem-MS of Liquid Urine or Urine Soaked Filter-Paper Strips for the Detection of Thymine-Uraciluria and Dihydropyrimidinuria....Pages 377-382
Screening for Purine and Pyrimidine Disorders Using Dried Urine Spots....Pages 383-388
Determination of Methylated Purine Bases in Urine from Healthy Subjects....Pages 389-392
Decrease in Urinary Uric Acid Concentrations after Urine Storage....Pages 393-397
Mass Spectrometry for Analysis of Purine and Pyrimidine Compounds....Pages 399-403