Purine and Pyrimidine Metabolism in Man V: Part B: Basic Science Aspects

Front Matter....Pages i-xviii
Adenosine Receptors on Human T Lymphocytes and Human Thymocytes....Pages 1-6
Adenosine Receptors on Human Lymphocytes....Pages 7-14
Inhibition of Mast Cell Mediator Release by 5-Amino-4-Imidazolecarboxamide Riboside....Pages 15-18
Purine Metabolism by Guinea-Pig Ileum....Pages 19-28
Suppression by 5′-Methylthioadenosine of Histamine or Leukotriene-Induced Contraction in Isolated Guinea Pig Tracheal Rings....Pages 29-33
Adenosine Receptors on Human Basophils and Lung Mast Cells....Pages 35-42
Hypoxanthine Uptake by Isolated Brain Microvessels....Pages 43-46
Morphine: Sites of Action in Guanosine Nucleoside Pathway....Pages 47-52
Purine and Monoamine Metabolites in Cerebrospinal Fluid....Pages 53-56
Characteristics of High Affinity and Low Affinity Adenosine Binding Sites in Human Cerebral Cortex....Pages 57-69
Hypoxanthine Transport Through Human Erythrocyte Membranes....Pages 71-74
Regulatory Aspects of Hypoxanthine Uptake by Human Erythrocytes....Pages 75-77
Mutant Mouse Cells with Nitrobenzylthioinosine-Insensitive Nucleoside Transport Functions....Pages 79-83
Carrier Mediated Uptake of Deoxyguanosine in Rat Liver Mitochondria....Pages 85-88
Mechanism of Thymineless Death....Pages 89-95
Enhancement of Methotrexate Cytotoxicity by Uracil Analogues that Inhibit Deoxyuridine Triphosphate Nucleotidohydrolase (dUTPase) Activity....Pages 97-104
Influence of Methotrexate on Purine and Pyrimidine Pools and on Cell Phase Distribution of Cultured Human Lymphoblasts....Pages 105-111
Modulation of Cytotoxicity and Metabolism of 5-Fluorouracil in two Intestine Cell Lines....Pages 113-120
Toxicity and Antitumor Effect of 5-Fluorouracil and its Rescue by Uridine....Pages 121-128
Synergy of Methotrexate and 6-Mercaptopurine on Cell Growth and Clono- Genicity of Cultured Human T-Lymphoblasts....Pages 129-134
Increased Availability of Phosphoribosyl Pyrophosphate as the Basis for Enhanced 6-Mercaptopurine Incorporation by Methotrexate, in Cultured Human Lymphoblasts....Pages 135-139
Regulation of Deoxyadenosine and Nucleoside Analog Phosphorylation by Human Placental Adenosine Kinase....Pages 141-149
The Biosynthesis of Deoxyguanosine Triphosphate in Herpes Simplex Type-1 Infected Vero Cells Treated with Acyclovir and Hydroxyurea....Pages 151-156
5-AZA-2′-Deoxycytidine Synergistic action with Thymidine on Leukemic Cells and Interaction of 5-AZA-dCMP with dCMP Deaminase....Pages 157-163
Selection of Purine Nucleoside Analogs based on Multiple Biological and Biochemical Parameters....Pages 165-169
Effect of m -Amsa on the Cellular Pharmacology of Ara-CTP in Human Leukemic Cells During Therapy with High-Dose Ara-C....Pages 171-175
5-Fluoro-5′-Deoxyuridine is an Inhibitor of Uridylate Nucleotidase in L1210 Leukemaemia....Pages 177-183
The Effect of Phosphonoformic acid on Wild type and Mutant S49 Cell Lines....Pages 185-189
Mechanisms of Deoxyguanosine Toxicity for Human T and B Lymphocytes....Pages 191-199
Role of Intracellular Deoxynucleoside Triphosphate Levels in DNA Repair in Human Lymphocytes....Pages 201-205
Genetic Analysis of Deoxyadenosine Toxicity in Dividing Human Lymphoblasts....Pages 207-211
Inhibition of 3 H-Thymidine Incorporation by Adenosine and Deoxyadenosine in Human Peripheral Lymphocytes and Malignant Lymphoid Cell Lines....Pages 213-219
S-Adenosylmethionine Metabolism as a Target for Adenosine Toxicity....Pages 221-226
Ethanol Induced Nucleotide Catabolism in Mouse T Lymphoblastoid Cells in Vitro....Pages 227-230
Increased Level of Ribonucleotide Reductase in Deoxyadenosine Resistant Adenosine Deaminase Deficient Human Histiocytic Lymphoma Cells....Pages 231-234
Inhibition of T Cell Cytotoxicity by Cyclosporine (CSA), Adenosine (ADO) and an Inhibitor of Adenosine Deaminase (ADA)....Pages 235-238
Mechanism of Urate Production by Guinea-Pig Ileum....Pages 239-243
 In Vitro Degradation of Pyrimidine Bases: Studies of Rat Liver Dihydropyrimidine Dehydrogenase....Pages 245-248
Regulation of Enzymes by Ligand Induced Change in Polymerization....Pages 249-254
Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes....Pages 255-258
Reversible Interconversion Between Sulfo and Desulfo Xanthine Dehydrogenase....Pages 259-262
Mammalian Mutants Genetically Altered in CTP Synthetase Activity....Pages 263-269
Increased Inosinate Dehydrogenase Activity in Mycophenolic acid Resistant Neuroblastoma Cells....Pages 271-274
Murine Lymphocytes and Lymphocyte Cell Lines Secrete Adenosine Deaminase....Pages 275-282
Identification of a Purine 5′-Nucleotidase in Human Erythrocytes....Pages 283-290
Human Placental Cytoplasmic 5′-Nucleotidase: Kinetics and Molecular Properties....Pages 291-297
Regulation of the Cytosol 5′-Nucleotidase of the Heart by Adenylate Energy Charge....Pages 299-303
Characterization of Hydroxyurea (HYU) Resistant S49 T Lymphoma Cells....Pages 305-309
Purification and Properties of Human Deoxycytidine Kinase....Pages 311-314
Purification of Mammalian Glycinamide Ribonucleotide (GAR) Synthetase....Pages 315-319
Steady-State Kinetics of the Reaction Catalyzed by GMP Reductase....Pages 321-324
Purine De Novo Synthesis and Salvage During Testicular Development in the Rat....Pages 325-328
Pathways of Adenine Nucleotide Catabolism in Human Erythrocytes....Pages 329-336
Mechanism of Increased Rate of De Novo Purine Biosynthesis in Rat Liver after Bilateral Adrenalectomy....Pages 337-345
Increase of Amidophosphoribosyltransferase activity and Phosphoribosylpyrophosphate Concentration as the Basis for increased De Novo Purine Biosynthesis in the Regenerating Rat Liver....Pages 347-355
Purine Metabolism in Human Neuroblastoma Cell Lines....Pages 357-362
Purine Biosynthesis in Chinese Hamster Cell Mutants and Human Fibroblasts Partially Deficient in Adenylosuccinate Lyase....Pages 363-369
Purine Synthetic Capacities of De Novo and Salvage Pathways in Rat Hepatoma 3924A Cells....Pages 371-376
Metabolism of Purine Nucleotide in the Liver and Kidney of Castrated Rats....Pages 377-380
The Hormonal Regulation of Purine Biosynthesis: Control of the Inosinic acid Branch Point....Pages 381-384
Production and Properties of Monoclonal Antibodies against Human Ecto-5′-Nucleotidase....Pages 385-389
AMP-Deaminase and Cytosolic 5′Nucleotidase in Human and Murine Lymphocyte Subpopulations....Pages 391-398
An Explanation for the Heterogeneity in B Lymphocyte Ecto-5′-Nucleotidase Activity in Patients with Hypogammaglobulinemia....Pages 399-405
Cell Surface Adenosine Deaminase (ADA) and its Complexing Protein (ADCP) in Human T-Lymphoid Cells....Pages 407-414
On the Role of Cytidine Deaminase in Cellular Metabolism....Pages 415-420
Purine Enzyme Activities as Markers of Lymphocytic Differentiation: Studies of Lymphocytes from Horses with Severe Combined Immunodeficiency (SCID)....Pages 421-427
The Effects of PNP Inhibition on Rat Lymphoid Cell Populations....Pages 429-435
Imbalance in Nucleotide Pools of Myeloid Leukemia Cells and HL-60 Cells: Correlation with Cell Cycle Phase, Cell Proliferation and Differentiation....Pages 437-441
Enhancement of T Cell Proliferation and Differentiation by 8-Mercaptoguanosine....Pages 443-449
Antigen-Specific Enhancement of the Human Antibody Response by a Substituted Nucleoside....Pages 451-458
Ectoenzymes of Nucleotide Metabolism on Human Lymphoid Cells....Pages 459-462
Separate Mechanisms for Cellular uptake of Purine Nucleotides by B- and T-Lymphoblasts....Pages 463-465
Ecto-5′-Nucleotidase Can use IMP to Provide the Total Purine Requirements of Mitogen-Stimulated Human T Cells and Human B Lymphoblasts....Pages 467-473
Changes of Purine Metabolism During Differentiation of Rat Heart Myoblasts....Pages 475-484
Production and Degradation of AMP in Cultured Rat Skeletal and Heart Muscle: A Comparative Study....Pages 485-491
Duchenne Muscular Dystrophy: Normal ATP Turnover in Cultured Cells....Pages 493-499
Inferences on the Rapid Metabolism of Exogenously applied ATP in isolated Smooth Muscle Preparations using Pharmacological Studies....Pages 501-505
Enzyme Activities of Purine Catabolism and Salvage in Human Muscle Tissue....Pages 507-509
Purine Salvage in Rat Heart Myoblasts....Pages 511-515
Skeletal Muscle Adenosine, Inosine and Hypoxanthine Release Following Ischaemic Forearm Exercise in Myoadenylate Deaminase Deficiency and McArdle’s Disease....Pages 517-523
Myoadenylate Deaminase Deficiency: Diagnosis by Forearm Ischemic Exercise Testing....Pages 525-528
Purine Nucleotides in Human Hearts During Open Heart Surgery....Pages 529-533
Cell Culture Models for the Study of Purine Metabolism in Human Placental Tissue....Pages 535-540
Purine Nucleotide Synthesis in Cultured Rat Embryos Undergoing Organogenesis....Pages 541-546
Evidence for a Membrane Adenosine Receptor in Leishmania Mexicana Mexicana (WR 227)....Pages 547-551
Adenine Phosphoribosyltransferase-Deficient Leishmania Donovani ....Pages 553-557
5′-Methylthioadenosine (MTA) Phosphorylase from Promastigotes of Leishmania Donovani ....Pages 559-563
6-Thiopurine Riboside Analogs: Their Toxicity and Metabolism in Leishmania Donovani and Mammalian Cells....Pages 565-571
Purine Salvage Enzymes in Trichomonas Vaginalis ....Pages 573-575
Biochemical Basis for Deoxyadenosine and 2-Chlorodeoxyadenosine Toxicity to Resting Human Lymphocytes....Pages 577-582
2-Chloroadenosine is Phosphorylated and Increases the Production of Hypoxanthine in Human Cells....Pages 583-587
Mechanism of Cytotoxicity of 2-Chloro and 2-Bromodeoxyadenosine for a Human Lymphoblastic Cell Line, CCRF-CEM....Pages 589-593
Genetic and Biochemical Characteristics of Three Different Types of Mutants of Mammalian Cells Affected in Adenosine Kinase....Pages 595-603
Characterization of Arabinosylguanine Resistance in a Lymphoblastoid Cell Line....Pages 605-609
The Synthesis of Phosphoribosylpyrophosphate from Glucose Decreases During Amino Acid Starvation of Human Lymphoblasts....Pages 611-614
Effect of Fructose on the Concentration of Phosphoribosylpyrophosphate in isolated Hepatocytes....Pages 615-621
The Mechanism of Insulin-Induced Increase of the Rate of De Novo Purine Biosynthesis in Primary Cultured Rat Hepatocytes....Pages 623-631
Hormone-Induced Stimulation of Phosphoribosylpyrophosphate and of Purine Synthesis in Mouse Liver in Vivo....Pages 633-637
Cobalamin Inactivation Decreases Purine and Methionine Synthesis in Cultured Human Lymphoblasts....Pages 639-641
5′-Deoxy-5′-Methylthioadenosine Phosphorylase Deficiency in Leukemia: Genetics and Biochemical Aspects....Pages 643-650
Metabolism of 5′-Methylthioadenosine in Methionine-Dependent and Methionine-Independent Cells....Pages 651-657
Inhibition of De Novo Purine Synthesis by Methylthioadenosine....Pages 659-662
Determination of S-Adenosylhomocysteine in Tissues Following Pharmacological Inhibition of S-Adenosylhomocysteine Catabolism....Pages 663-666
4′-Thioadenosine as a Novel Inhibitor of S-Adenosylhomocysteine Hydrolase and an Inducer for the Differentiation of HL-60 Human Leukemia Cells....Pages 667-672
 In Vivo Inhibition of Mouse Liver Methyltransferase Enzymes Following Treatment with 2′-Deoxycoformycin and 2′-Deoxyadenosine....Pages 673-675
Alteration of Ribonucleotide and Deoxyribonucleotide Metabolism by Interferon in Human B- Lymphoblastoid Cells....Pages 677-681
Inhibitor of 2′ 5′-Oligoadenylate Synthetase Induced in Human T Lymphoblastoid Cell Line treated with Deoxyadenosine, Deoxycoformycin and Interferon....Pages 683-687
2-5A Synthetase Activities in Herpes Virus Infection and after Interferon Treatment....Pages 689-692
Back Matter....Pages 693-701