Purine and Pyrimidine Metabolism in Man IX

Front Matter....Pages i-xxiii
Front Matter....Pages xxv-xxv
Gout New Questions for an Ancient Disease....Pages 1-5
Efficacy of Allopurinol in Ameliorating the Progressive Renal Disease in Familial Juvenile Hyperuricaemic Nephropathy (FJHN)....Pages 7-11
Optimal Range of Serum Urate Concentrations to Minimize Risk of Gouty Attacks During Anti-Hyperuricemic Treatment....Pages 13-18
How Should we Treat Tophaceous Gout in Patients with Allopurinol Hypersensitivity?....Pages 19-23
The Spectrum of HGPRT Deficiency....Pages 25-29
Plasma Uridine as well as Uric Acid is Elevated Following Fructose Loading....Pages 31-35
Inverse Relationship Between Serum Triglyceride Levels and Fractional Urate Excretion....Pages 37-40
Microanalysis of Pathological Crystals and Urinary Calculi....Pages 41-45
Zonal Distribution of Allopurinol-Oxidizing Enzymes in Rat Liver....Pages 47-50
Severe Debilitating Polyarticular Gout and Terminal Renal Failure in an Allopurinol ‘Non-Responder’....Pages 51-55
Decreased Serum Concentrations of 1,25(OH)2-Vitamin D3 in Patients with Gout....Pages 57-60
Lipoproteins in Patients with Isolated Hyperuricemia....Pages 61-67
Atherogenic Risk Factors in Patients with Gout....Pages 69-72
Mast Cell Adenosine Receptor Characteristics and Signaling....Pages 73-78
Purine and Pyrimidine Nucleoside Content of the Neuronal Extracellular Space in Rat....Pages 79-82
Effect of FMLP Stimulation on [ 3 H]-NECA Binding to Adenosine Receptors in Neutrophils Membranes....Pages 83-87
Effects of Nucleoside Transport Inhibitors and Adenine/Ribose on ATP Concentration and Adenosine Production in Cardiac Myocytes....Pages 89-94
Purification of a Protein Involved in ADP Formation....Pages 95-98
ADP Formation In Rat Liver....Pages 99-102
A 1 Adenosine Receptors in Human Neutrophils....Pages 103-105
Purification and Some Molecular Properties of Pigeon Heart AMP-Selective 5′-Nucleotidase....Pages 107-111
Succinylpurines do not Modify Glutamate or Adenosine Effects in the CNS....Pages 113-117
Clinical and Biochemical Aspects of Dihydropyrimidinase Deficiency....Pages 119-123
The Genetic Basis of Myoadenylate Deaminase Deficiency is Heterogeneous....Pages 125-128
The Origin of APRT*J the Most Common Disease-Related Mutation of APRT Gene Among Japanese Goes Back to a Prehistoric Era....Pages 129-133
HGPRT and Aprt Activities in Hemolysates During the First Year of Life....Pages 135-139
Delayed Hypersensitivity to 5-Fluorouracil Associated with Reduced Dihydropyrimidine Dehydrogenase (DPD) Activity....Pages 141-145
HPRT-Mutations in Italian Lesch-Nyhan Patients....Pages 147-150
Erythrocyte Cdp-Choline Accumulation in Haemolytic Anaemia and Renal Failure (Rf)....Pages 151-153
Erythrocyte UMP Synthetase Activity....Pages 155-159
Nonrandom Selection of Hair Follicles in HPRT Heterozygosity....Pages 161-165
Optimised Micellar Electrokinetic Capillary Chromatography of UV-Absorbing Compounds in Urine....Pages 167-170
Effect of D-Ribose Administration to a Patient with Inherited Deficit of Adenylosuccinase....Pages 171-176
Enzyme Activities Leading to NAD Synthesis in the Erythrocytes of Hprt Deficient Subjects....Pages 177-180
Succinylpurines Induce Neuronal Damage in the Rat Brain....Pages 181-184
Urinary Screening for Pyrimidine Metabolism Disorders....Pages 185-189
Carrier State in Hgprt Deficiency a Study in 14 Spanish Families....Pages 191-195
Genetic Diagnosis of Hypoxanthine-Guanine Phosphoribosyltransferase (Hgprt) Carrier Status by Restriction Analysis and Directed Mutagenesis....Pages 197-200
Muscle Purine Nucleotide Cycle Enzymes in Exercise Intolerance....Pages 201-204
Prenatal Diagnosis of HPRT Mutant Genes in Lesch-Nyhan Syndrome....Pages 205-209
Regulation of Human PRS Isoform Expression....Pages 211-214
Structure and Functional Relationships in Human pur H....Pages 215-220
Localization of Carbamoyl-Phosphate Synthetase II (Cps Ii) and Aspartate Carbamoyltransferase (Act) Genes in trypanosoma Cruzi Chromosomal DNA....Pages 221-226
Expression and Characterization of Recombinant Bovine Cytosolic 5′-Nucleotidase IMP-GMP Specific....Pages 227-230
Molecular Characterization of a Carbamoyl-Phosphate Synthetase II (Cps II) Gene from leishmania Mexicana ....Pages 231-235
Substrate Channelling by Human IMP Synthase....Pages 237-240
Inhibition of Adenylosuccinate Lyase By 2′, 3′-Acyclic Substrate Analogs....Pages 241-244
Regulation of Deoxycytidine Kinase by Deoxycytidine and Deoxycytidine 5′ Triphosphate in Whole Leukemia and Tumor Cells....Pages 245-248
Kinetic Properties of CTP Synthetase from Hl-60 Cells....Pages 249-253
 cellulomonas sp . Purine Nucleoside Phosphorylase (PNP)....Pages 255-258
Subdomain Structure of Carbamyl Phosphate Synthetase....Pages 259-264
The Effects of Nucleotide Pool on Purine Production in the Postischemic Heart....Pages 265-269
Muscle Energy Metabolism in Human Adenylosuccinase Deficiency....Pages 271-274
Cardioprotection by Ischemic Preconditioning....Pages 275-278
High-Energy Phosphate Changes in the Normal and Hypertrophied Heart During Cardioplegic Arrest and Ischemia....Pages 279-282
Role of Glutamate-67 in the Catalytic Mechanism of Human Cytidine Deaminase....Pages 283-286
Heterozygosity for a Point Mutation in an Invariant Splice Donor Site of Dihydropyrimidine Dehydrogenase and Severe 5-Fluorouracil Related Toxicity....Pages 287-291
Site Directed Mutagenesis of the saccharomyces Cerevisiae Apt1 Gene....Pages 293-298
Studies on Cysteine Residues Involved in the Active Site of Human Cytidine Deaminase....Pages 299-303
Relationship of the Two APRT Gene Products from saccharomyces Cerevisiae ....Pages 305-308
Structural and Functional Analysis of the Human TPMT Gene Promoter....Pages 309-314
A First Evidence of an Asymptomatic Germline Missense Base Substitution in the Hypoxanthine Phosphoribosyltransferase (HPRT) Gene in Humans....Pages 315-318
Genetic Basis of Adenylosuccinase Deficiency in an Italian Patient....Pages 319-322
Mutations in Xanthine Dehydrogenase Gene in Subjects with Hereditary Xanthinuria....Pages 323-325
Role of Cysteine and Lysine Residues in Human Hypoxanthine-Guanine Phosphoribosyltransferase....Pages 327-330
Molecular Analysis of Mouse ampd3 Gene Encoding Heart-Type Isoform of Amp Deaminase....Pages 331-335
Dihydropyrimidine Dehydrogenase Deficiency....Pages 337-340
Gene Mutations Responsible for Human Erythrocyte AMP Deaminase Deficiency in Poles....Pages 341-346
Response of Purine Metabolism to Hypoxia and Ischemia....Pages 347-350
Endothelial Purine Metabolism and Reperfusion Injury....Pages 351-357
Adenosine-Induced Preconditioning of Rat Neuronal Cultures Against Ischemia-Reperfusion Injury....Pages 359-364
Myocardial Ischemic Injury During Cardio-Pulmonary by-Pass....Pages 365-368
Nucleotide Metabolism in the Heart Subjected to Heat Stress....Pages 369-372
Differences in Nucleotide Metabolism and Mechanical Recovery after Cardioplegic Arrest of the Heart at Different Age....Pages 373-376
Different Mechanism of Myocardial Nucleotide Breakdown During Normothermic and Hypothermic Ischemia....Pages 377-379
Effects of Adenine/Ribose Supply on Adenosine Production and ATP Concentration in Adenosine Kinase Inhibited Cardiac Cells....Pages 381-383
A Nucleotide and Nucleosides Mixture Solution Improves Recovery of Energy Metabolism after Hepatic Ischemia in Rats....Pages 385-388
Can Adenosine Deaminase Inhibitors be Cytoprotective Agents?....Pages 389-393
Role of Purine Metabolism in Regulation of Signal Transduction in Human Carcinoma Cells....Pages 395-399
Role Of Adenosine Deaminase and dATP Levels in Thymocyte Apoptosis....Pages 401-408
Structure and Function of P2Y 2 Nucleotide Receptors in Cystic Fibrosis (CF) Epithelium....Pages 409-415
Deoxycytidine Kinase can be also Potentiated by the G-Protein Activator NaF in Cells....Pages 417-424
Low GTP Induces PKC-β-Dependent Myeloid Cell Differentiation....Pages 425-428
Exogenous S-Adenosyl-Methionine Methylates Phospholipids Located on the Outer Cell Surface of Isolated Rat Hepatocytes....Pages 429-432
Imp-Dehydrogenase (IMPDH), Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), and Phosphodiesterases (PDEs) Expression During Mycophenolic Acid (MPA)-Induced Differentiation in Human Neuroblastoma Cell Lines....Pages 433-437
Differentiating and Biochemical Effects of a Reduction of Intracellular GTP Levels Induced by Mycophenolic Acid (MPA) in Human Neuroblastoma (NB) Cell Lines....Pages 439-441
New Models for the Study of Adenosine Deaminase Deficiency....Pages 443-446
Insights into Adenosine Deaminase Deficiency Provided by Murine Fetal Thymic Organ Culture with 2′-Deoxycoformycin....Pages 447-449
Thymidine Kinase Expression....Pages 451-454
Neuroblastoma Cell Apoptosis Induced by Mycophenolic Acid....Pages 455-460
The Single Deoxynucleoside Kinase in Drosophila Melanogaster, Dm -dnk, is Multifunctional and Differs from the Mammalian Deoxynucleoside Kinases....Pages 461-464
Effect of Deoxynucleosides on the Repair of UV Induced DNA Breaks....Pages 465-469
A New Model Organism for Studying the Catabolism of Pyrimidines and Purines....Pages 471-474
Cad Overexpression in Mammalian Cells....Pages 475-479
Azathioprine Treatment and Thiopurine Metabolism in Rheumatic Diseases....Pages 481-485
Identification of Multiple forms of the Cytosolic 5′-Nucleotidase/Phosphotransferase in Rat Tissues....Pages 487-493
Regulation of Deoxynucleotide Pools by Substrate Cycles....Pages 495-499
Dihydroorotate Dehydrogenase....Pages 501-506
Purine Nucleoside Phosphorylase Deficient Mice Exhibit Both an Age Dependent Attrition of Thymocytes and Impaired Thymocyte Differentiation....Pages 507-513
Activation of Deoxycytidine Kinase During Inhibition of DNA Synthesis in Human Lymphocytes....Pages 515-518
Similar Changes Were Induced by Cladribine and by Gemcitabine, in the Deoxypyrimidine Salvage, During Short Term Treatments....Pages 519-523
Effect of Cladribine, Fludarabine, and 5-AZA-Deoxycytidine on S-Adenosylmethionine (SAM) and Nucleotides Pools in Stimulated Human Lymphocytes....Pages 525-529
Inhibition of Inosine Monophosphate Dehydrogenase Activity by the Plasma of Heart Transplant Recipients Receiving Mycophenolate Mofetil....Pages 531-535
Changes of Polymorphonuclear Leukocyte (PMN) Functions Under Dietary Nucleic Acid Deficiency and Effects of Administration of Nucleotide and Nucleosides Mixture Solution in Mice....Pages 537-541
Differentiation and Reduction of Intracellular GTP Levels in Hl-60 and U937 Cells Upon Treatment with IMP Dehydrogenase Inhibitors....Pages 543-547
Isoenzymes of 5′-Nucleotidase in Human Lymphocytes....Pages 549-553
Biochemical Basis for the Impaired Immune Response in Chronic Renal Failure?....Pages 555-558
Mycophenolic Acid Influences the Expression of ICAM-1 on Human Endothelial Cells....Pages 559-563
Reaction of 2′, 3′-Dideoxynucleotides Triphosphates with Recombinant Human Nucleoside Diphosphate Kinase....Pages 565-568
Antitumor Activity of Yunnanmycin....Pages 569-573
Mechanisms of Synergism Between Gemcitabine and Cisplatin....Pages 575-579
Cross-Resistance of the Gemcitabine Resistant Human Ovarian Cancer Cell Line AG6000 to Standard and Investigational Drugs....Pages 581-585
Increased Sensitivity to Gemcitabine of P-gP and MRP Overexpressing Human Non-Small Cell Lung Cancer Cell Lines....Pages 587-590
Does 2-Chlorodeoxyadenosine Contribute to Alteration of DNA Methyltransferase Activity?....Pages 591-594
Iron Binding Capacity of Didox (3,4 Dihydroxybenzohydroxamic Acid) and Amidox (3,4 Dihydroxybenzamidoxime) two Inhibitors of the Enzyme Ribonucleotide Reductase....Pages 595-598
 In Vitro and in Vivo Inhibitory Activity of the Differentiation-Inducing Agent 9-(2-Phosphonylmethoxyethyl)Adenine (Pmea) Against Rat Choriocarcinoma....Pages 599-604
Increased Cell Killing and Mutagenecity by DNA Alkylating Agents in Cells with Decreased TTP Pools....Pages 605-609
N 4 -Hydroxy-5-Halogeno-2′-Deoxycytidine S and Their 5′-Mono-Phosphates as Inhibitors of Thymidylate Synthase and in Vitro Antileukemic Agents....Pages 611-616
Substrate/Inhibitor Specificities of Human Deoxycytidine Kinase (DCK) and Thymidine Kinases (TK1 and TK2)....Pages 617-621
Investigation of Isoenzymes of Adenylosuccinase in Human Blood Cells....Pages 623-627
Dihydropyrimidine Dehydrogenase in Livers from Mouse and Rat, and in Human Liver, Colon Tumors, and Mucosa in Relation to Anabolism of 5-Fluorouracil....Pages 629-632
Induction of in Vivo Resistance Against Gemcitabine (dFdC,2′,2′-Difluoro-Deoxycytidine)....Pages 633-636
Activation of Deoxycytidine Kinase by Various Nucleoside Analogues....Pages 637-640
Clinical Pharmacology of Intermediate and Low-Dose Cytosine Arabinoside (ara-C) Therapy in Patients with Hematologic Malignancies....Pages 641-645
The Role of Thymidine Kinase Activity in Murine Colon Tumours Treated with 5-Fluorouracil....Pages 647-651
Role of Deoxycytidine Kinase (dCK), Thymidine Kinase 2 (TK2), and Deoxycytidine Deaminase (dCDA) in the Antitumor Activity of Gemcitabine (dFdC)....Pages 653-656
Differential Effects of Gemcitabine on Nucleotide Pools of 19 Solid Tumor Cell Lines....Pages 657-660
Increased Activity of Cytidine triphosphate Synthetase in Pediatric Acute Lymphoblastic Leukemia....Pages 661-665
Expression of Human Cytosolic Thymidine Kinase in Escherichia Coli ....Pages 667-671
Structure-Activity Relationship in Ftorafur (Tegafur) and Related 5-Fu Prodrugs....Pages 673-676
Measurement of Mutation Frequency at the HPRT Locus in Peripheral Lymphocytes....Pages 677-680
Thiopurine Treatment in Childhood Leukemia....Pages 681-686
Relationship Between Cladribine (CDA) Plasma, Intracellular Cda-5′-Triphosphate (CDATP) Concentration, Deoxycytidine Kinase (DCK), and Chemotherapeutic Activity in Chronic Lymphocytic Leukemia (CLL)....Pages 687-692
Determinants of the Therapeutic Efficacy of Thymidylate Synthase Inhibitors....Pages 693-697
Pyrimidine Antagonists and Antifolates as Antimalarial Drugs....Pages 699-704
Adenine Nucleoside Phosphorylases in Trematode Fasciola Hepatica , the Mammalian Parasite....Pages 705-709
Inhibition by 3′-Azido-3′-Deoxythymidine (AZT) of trypanosoma Cruzi Growth in Mammalian Cells and a Possible Mechanism of Action....Pages 711-717
Metabolism of Eicar (5-Ethynyl-1-β-D- Ribofuranosylimidazole-4-Carboxamide),A Potent Inhibitor of Inosinate Dehydrogenase....Pages 719-722
A HPLC Method for the Monitoring of Human Red Cell 6-Thioguanine and Methyl 6-Mercaptopurine in a Single Run....Pages 723-728
Expression and Properties of Recombinant P. Falciparum Hypoxanthine-Guanine Phosphoribosyltransferase....Pages 729-734
Determination of Thiopurine Methyltransferase Activity in Erythrocytes Using 6-Thioguanine as the Substrate....Pages 735-739
Antiviral Acyclic Nucleoside Phosphonate Analogues as Inhibitors of Purine Nucleoside Phosphorylase....Pages 741-745
Metabolism and Anti-HIV Activity of Phosphoramidate Derivatives of D4T-MP with Variations in the Amino Acid Moiety....Pages 747-752
Determination of Purine Enzyme Activities in Human Erythrocytes by Capillary Electrophoresis....Pages 753-757
Capillary Electrophoretic Analysis of Hypoxanthine and Xanthine for the Diagnosis of Xanthinuria....Pages 759-763
Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia....Pages 765-767
Hypoxanthine and Xanthine as Markers in Early Diagnosis of Foetal Diseases....Pages 769-776
Effects of Dipyridamole and Adenine/Ribose on ATP Concentration and Adenosine Production in Cardiac Myocytes....Pages 777-780
Evaluation Of Adenine Concentration in Plasma of Patients with Renal Failure Using Improved Ultrafiltration Technique....Pages 781-784
A Syndrome of Seizures and Pervasive Developmental Disorder Associated with Excessive Cellular Nucleotidase Activity....Pages 785-787
 de Novo Purine Synthesis is Increased in the Fibroblasts of Purine Autism Patients....Pages 789-792
Determination and Separation of Allantoin, Uric Acid, Hypoxanthine, and Xanthine by Capillary Zone Electrophoresis....Pages 793-796
Pharmacokinetics of Mycophenolate Mofetil in Heart Transplant Recipients....Pages 797-800
Immunohistochemical Analysis of P185 and ASL Activity in Pre-Neoplastic Lesions and Intestinal Mucosa of Human Subjects....Pages 801-803
No Circadian Variation of Dihydropyrimidine Dehydrogenase, Uridine Phosphorylase, β-Alanine, and 5-Fluorouracil During Continuous Infusion of 5-Fluorouracil....Pages 805-809
Subcellular Localization of Dihydropyrimidine Dehydrogenase....Pages 811-816
The Activity of Dihydropyrimidine Dehydrogenase in Human Blood Cells....Pages 817-821
Endothelial Purine Content....Pages 823-826
Influence of Glycopeptide Antibiotics on Purine Metabolism of Endothelial Cells....Pages 827-831
Effect of Tofu (Bean Curd) Ingestion on Uric Acid Metabolism in Healthy and Gouty Subjects....Pages 833-838
Purines and Pyrimidines Determination in Urine Using High-Performance Liquid Chromatography....Pages 839-842
Design, Synthesis, and Structure-Activity Relationships of the First Highly Potent, Selective, and Bio Available Adenosine 5′-Monophosphate Deaminase Inhibitors....Pages 843-848
Design and Synthesis of the First Potent, Selective, and Cell Penetrating Adenosine 5′-Monophosphate Deaminase Inhibitors....Pages 849-852
Erratum to: Effects of Nucleoside Transfort Inhibitors and Adenine/Riboseon ATP Concentration and Adenosine Production in Cardiac Myocytes....Pages 853-857
Erratum to: Energy Metabolism in the Failing Human Heart with Dilated or Hypertrophic Cardiomyopathy.....Pages 867-867
Back Matter....Pages 867-867
....Pages 859-866