PTSD: Brain Mechanisms and Clinical Implications

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Contents......Page 8
Preface......Page 5
Part 1: Basic Mechanism of PTSD and Stress-Related Brain Dysfunctions......Page 11
Neuroanatomical and Molecular Changes in Stress Responses During Early Life: Implications for Stress Disorders......Page 12
Cortisol and PTSD: Animal Experiments and Clinical Perspectives......Page 21
Stress and Corticosteroid Receptors......Page 36
Stress Vulnerability Induced by Neonatal Isolation and the Disturbance Between the Phosphorylation and Dephosphorylation of CREB......Page 44
Neuroscience of Emotional Memory and Posttraumatic Stress Disorder......Page 53
Studies on Pathophysiology of PTSD Using the SPS Model......Page 60
Mechanisms of Lasting Change in Anxiety Induced by Severe Stress......Page 65
Altered Emotional Behaviors in Mammalian Bombesin Receptor Knockout Mice: Implication for the Molecular Pathogenesis of Stress-Induced Psychiatric Disorders in Humans......Page 86
Role of Stress Hormones and the Amygdala in Creating Lasting Memories......Page 92
Drug Discovery for PTSD: Characterization of an Animal Model of PTSD and PET Imaging of Brain Glucocorticoid Receptor......Page 107
Tissue Metabolism of Glucocorticoids: New Controls of Cognitive Function and the Stress Response......Page 114
Maternal Deprivation in Neonatal Period and Biological Rhythms......Page 137
Part 2: Clinical Implications for PTSD and Perspectives in Psychiatry......Page 145
Current Perspectives on Clinical Studies of PTSD in Japan......Page 146
Psychosocial and Genetic Susceptibility to Posttraumatic Stress Disorder......Page 154
Intrusion in Women with Breast Cancer......Page 167
Earthquake-Related PTSD: A Follow-up Study in Prevalence, Comorbidity, Quality of Life, and Biological Correlates......Page 177
Psychological Consequences for Students Who Survived the Ehime Maru Accident: A 26-Month Follow-Up Study......Page 190
Structural and Functional Neuroimaging in Posttraumatic Stress Disorder......Page 200
Functional Neuroimaging Research in Posttraumatic Stress Disorder......Page 207
Functional Abnormality of the Prefrontal Cortex in Posttraumatic Stress Disorder: Psychophysiology and Treatment Studies Assessed by Near-Infrared Spectroscopy......Page 230
Neural Correlates of Symptom Improvement in Posttraumatic Stress Disorder: Positron Emission Tomography Study......Page 241
Cognitive Behavior Therapy: Implications from Advances in Neuroscience......Page 249
Pharmacological Interventions for Posttraumatic Stress Disorder......Page 264
Secondary Pharmacological Prevention of PTSD: Therapeutic Implications of a Translational Model......Page 274
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