Psychotic Depression

Cover......Page 1
Half-title......Page 3
Title......Page 7
Copyright......Page 8
Dedication......Page 9
Contents......Page 11
Preface......Page 13
Acknowledgments......Page 17
1 Introduction......Page 19
What is psychotic depression?......Page 21
Patients......Page 31
Questions......Page 34
2 History of Psychotic Depression......Page 39
Differentiating melancholy......Page 42
Swimming in and out of view......Page 55
The DSM series: psychotic depression as a subclass of ‘‘major depression’’......Page 61
Psychotic depression as an independent disease......Page 67
Problems with the DSM definition of psychotic depression......Page 77
Issues with the ICD-10 description of psychotic depression......Page 83
The psychosis......Page 84
Psychosis and evidence......Page 86
The behaviors of psychotic depression......Page 87
Suicidal behavior......Page 88
Who gets psychotic depression and the risks......Page 90
Schizoaffective or psychotic depression?......Page 93
Delusional disorder versus psychotic depression......Page 96
Rapid cycling......Page 97
Melancholic psychotic depression......Page 98
Psychosis-dominant depression......Page 101
Catatonic psychotic depression......Page 109
Psychotic-equivalent depression......Page 118
Tardive psychotic depression......Page 119
Drug-induced and hormone-induced psychotic depression (including postpartum psychosis)......Page 122
Coarse brain disease psychotic depression......Page 124
Pseudopsychosis, or false psychotic depression......Page 130
Unclear circumstances......Page 134
Psychotic versus nonpsychotic major depression......Page 137
Depression-induced anxiety disorders......Page 139
4 Patients’ Experience of Illness......Page 146
Pain not sadness......Page 149
Delusional content......Page 154
Prognosis......Page 157
An illness that awaits good news......Page 162
Convulsive therapy......Page 165
Antimelancholic medication: Chlorpromazine......Page 168
Antimelancholic medication: The tricyclic antidepressants......Page 173
Antimelancholia: new treatment possibilities......Page 178
6 Treatment: Pitfalls and Pathways......Page 185
Treatment versus management......Page 188
Common pitfalls in studying treatment......Page 191
Unaccounted drug effects......Page 193
Rating scale shortcomings......Page 199
Places for treatment and ECT......Page 203
A common path to treatment......Page 207
Electroconvulsive therapy......Page 210
ECT: The procedure......Page 213
ECT: Mechanisms......Page 216
Prevention of recurrence after ECT......Page 219
ECT versus medications......Page 220
Safety of ECT versus antipsychotic drugs......Page 223
Antimelancholic drugs alone......Page 225
Antidepressant-induced mania......Page 227
Tricyclics with triiodothyronine in females......Page 229
Lithium......Page 231
Antipsychotic drugs alone......Page 232
Antipsychotic-antimelancholic combination......Page 236
Adding a third drug to antimelancholic-antipsychotic......Page 239
Monoamine Oxidase Inhibitors (MAOIs)......Page 240
Lamotrigine......Page 241
Serotonin Reuptake Inhibitors (SRIs, SSRIs)......Page 242
Combination antipsychotic-fluoxetine and -paroxetine......Page 244
Other SSRIs in combination with antipsychotics......Page 246
Anticorticoids......Page 247
Mirtazapine, Nefazodone, Topiramate......Page 248
Repetitive Transcranial Magnetic Brain Stimulation (TMS)......Page 249
Surgery, deep brain stimulation, vagal nerve stimulation......Page 250
Melancholic psychotic depression......Page 253
Preventing recurrence of the melancholic type......Page 261
Bipolar mixed state subtype......Page 263
Deteriorative subtype......Page 264
Treating severe anxiety disorder......Page 265
Preventing recurrence of psychosis-dominant type......Page 268
Catatonic psychotic depression......Page 269
Psychotic-equivalent depression......Page 271
The lithium method for tardive psychosis......Page 272
The clozapine method for tardive psychosis......Page 273
Drug-induced and hormone-induced psychotic depression......Page 274
Psychotic depression in epilepsy and epileptic psychotic depression – other coarse brain disease......Page 275
Pseudopsychosis......Page 277
Untyped, Unknown, Unclear......Page 278
Residual depressive symptoms and PTSD......Page 279
History of illness and mental status examination......Page 281
Psychiatric diagnosis......Page 284
Laboratory tests in psychiatry......Page 285
Antipsychotic tranquilizers......Page 287
Dopamine-blocker drugs......Page 288
Dopamine blockers that rarely cause drowsiness......Page 289
Dopamine blockers that often cause drowsiness......Page 290
Prefrontal inhibitors......Page 291
Mixed dopamine blockers – prefrontal inhibitors......Page 292
Antimelancholic antidepressants......Page 293
Antiobsessionals......Page 295
Miscellaneous psychotropics......Page 296
Tension reducers......Page 297
Benzodiazepine tranquilizers......Page 299
References......Page 301
Index......Page 323