Protein Phosphorylation in Health and Disease

Content: 
Copyright
Page iv

Contributors
Pages xi-xiii

Preface
Pages xv-xvii
Shirish Shenolikar

Mass Spectrometric Tools for Systematic Analysis of Protein Phosphorylation
Pages 3-32
Nicole St-Denis, Anne-Claude Gingras

Signaling in Striatal Neurons: The Phosphoproteins of Reward, Addiction, and Dyskinesia
Pages 33-62
Jean-Antoine Girault

Multiple Roles of STAT3 in Cardiovascular Inflammatory Responses
Pages 63-73
Cheh Peng Lim, Xin-Yuan Fu

Targeting Phosphorylation of Eukaryotic Initiation Factor-2α to Treat Human Disease
Pages 75-106
Melissa J. Fullwood, Wei Zhou, Shirish Shenolikar

The Role of Protein Phosphorylation in Therapy Resistance and Disease Progression in Chronic Myelogenous Leukemia
Pages 107-142
Wen Chun Juan, S. Tiong Ong

Role of the JNK Pathway in Human Diseases
Pages 145-169
Kanaga Sabapathy

PAKs in Human Disease
Pages 171-187
Perry M. Chan, Ed Manser

Chapter 8 - Phosphoproteins in Stress-Induced Disease
Pages 189-221
Lucy E. Dalton, Eleanor Healey, James Irving, Stefan J. Marciniak

Chapter 9 - HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
Pages 223-250
Ewan F. Dunn, John H. Connor

Protein Tyrosine Phosphatases in Cancer: Friends and Foes!
Pages 253-306
David P. Labbé, Serge Hardy, Michel L. Tremblay

Wip1-Dependent Signaling Pathways in Health and Diseases
Pages 307-325
Yun-Hua Zhu, Dmitry V. Bulavin

Phosphatases Driving Mitosis: Pushing the Gas and Lifting the Brakes
Pages 327-341
Erika Segear Johnson, Sally Kornbluth

Protein Phosphatases and Alzheimer\'s Disease
Pages 343-379
Steven P. Braithwaite, Jeffry B. Stock, Paul J. Lombroso, Angus C. Nairn

G-substrate: The Cerebellum and Beyond
Pages 381-416
Shogo Endo

Index
Pages 417-429