Protein Engineering. Applications in Science, Medicine, and Industry

Content: 
Front Matter, Page iii
Copyright, Page iv
Preface, Page xiii, Masayori Inouye, Raghupathy Sarma
1 - Classical Protein Chemistry in a World of Slicing and Splicing, Pages 3-13, CHRISTIAN ANFINSEN
2 - Protein Sequence Data Banks: The Continuing Search for Related Structures, Pages 15-27, R.F. DOOLITTLE
3 - The Analysis of Homologous Tertiary Structures and the Design of Novel Proteins, Pages 29-40, D.J. BARLOW, T.L. BLUNDELL, M.S. EDWARDS, B.L. SIBANDA, M.J.E. STERNBERG, W.R. TAYLOR, J.M. THORNTON
4 - Structural Implications for Macromolecular Recognition and Redesign, Pages 41-69, ELIZABETH D. GETZOFF, ROBERT A. HALLEWELL, JOHN A. TAINER
5 - The Design and Construction of Biologically Active Peptides, Including Hormones, Pages 71-79, EMIL THOMAS KAISER
6 - Structural and Functional Analysis of Thermophile Proteins, Pages 81-93, TAIRO OSHIMA
7 - The Conformation of Diphtheria Toxin: A Protein That Penetrates Membranes at Low pH, Pages 95-110, ERWIN LONDON, MICHAEL G. BLEWITT, AMITABHA CHATTOPADHYAY, LAURA A. CHUNG, JIAN-MIN ZHAO
8 - Design and Total Chemical Synthesis of a Gene for Bovine Rhodopsin, Pages 111-123, DANIEL D. OPRIAN, MICHAEL NASSAL, LUCA FERRETTI, SADASHIVA S. KARNIK, H. GOBIND KHORANA
9 - Surface-Simulation Synthesis and Its Applications in Protein Molecular Recognition, Pages 125-153, M. ZOUHAIR ATASSI
10 - Functional Analysis of the Signal Peptide for Protein Secretion with Use of Oligonucleotide-Directed Site-Specific Mutagenesis, Pages 157-171, SUSAN LEHNHARDT, SUMIKO INOUYE, MASAYORI INOUYE
11 - Physical Properties of Genetically Defined Synthetic Signal Sequences Suggest Initial Steps in Protein Export, Pages 173-191, LILA M. GIERASCH, MARTHA S. BRIGGS, DONALD G. CORNELL
12 - Studies on the Mechanism of Membrane Fusion, Pages 193-215, MARY-JANE GETHING, ROBERT W. DOMS, JUDY WHITE, ARI HELENIUS
13 - Expression and Site-Specific Mutagenesis of an Integral Membrane Protein, Bacterio-Opsin, Pages 217-232, SADASHIVA S. KARNIK, MARK S. BRAIMAN, BETTY H. CHAO, ROBERT DUNN, MARIE A. GILLES-GONZALEZ, NEIL R. HACKETT, ERNEST JAY, K. ANNE KRONIS, MICHAEL NASSAL, H. GOBIND KHORANA
14 - Stability Mutants of Staphylococcal Nuclease: A Correlation between Nuclease Activity in an Agar Gel Assay and Stability to Guanidine Hydrochloride Denaturation, Pages 233-241, DAVID SHORTLE
15 - Mutagenesis of the Arc Repressor Using Synthetic Primers with Random Nucleotide Substitutions, Pages 243-256, ANDREW K. VERSHON, KAREN BLACKMER, ROBERT T. SAUER
16 - Investigation of the Structural Roles of Disulfides by Protein Engineering: A Study with T4 Lysozyme, Pages 257-274, RONALD WETZEL
17 - Genetic Identification of Amino Acid Sequences Influencing Protein Folding, Pages 275-291, JONATHAN KING, MYEONG-HEE YU, JAVED SIDDIQI, CAMERON HAASE
18 - Structural Basis for Acetylcholine Receptor Function, Pages 295-309, MASAYOSHI MISHINA, SHOSAKU NUMA
19 - Protein Engineering of Antibody Molecules, Pages 311-317, MICHAEL S. NEUBERGER, GARETH T. WILLIAMS
20 - Proteolytic Processing of the Poliovirus Polyprotein by Two Virus-Encoded Proteinases, Pages 319-337, HARUKA TOYODA, MARTIN J.H. NICKLIN, MICHAEL G. MURRAY, ECKARD WIMMER
21 - Enzymatic Reactions in Organic Media, Pages 341-349, ALEXANDER M. KLIBANOV
22 - Antibody Targeting of Toxin Polypeptides, Pages 351-363, A.E. FRANKEL, M.J. BJORN, J.L. WINKELHAKE
23 - Production of Novel Antibiotics by Gene Cloning and Protein Engineering, Pages 365-381, RICHARD H. BALTZ, JEFFREY T. FAYERMAN, THOMAS D. INGOLIA, R. NAGARAJA RAO
24 - Genetic Transformation of Plants, Pages 383-393, ERNEST G. JAWORSKI, ROBERT T. FRALEY, STEPHEN G. ROGERS, ROBERT B. HORSCH, ROGER N. BEACHY, NAM-HAI CHUA
25 - Genetic Engineering of Bioinsecticides, Pages 395-413, DAVID R. WILCOX, ANNAPUR G. SHIVAKUMAR, BRIAN E. MELIN, MAHLON F. MILLER, TERRY A. BENSON, CYNTHIA W. SCHOPP, DIANNE CASUTO, GERARD J. GUNDLING, TIMOTHY J. BOLLING, BRIAN B. SPEAR, J. LAWRENCE FOX
Index, Pages 415-424