Protein Conformation as an Immunological Signal

Front Matter....Pages i-xiv
Introduction....Pages 1-2
Antibody-Hapten Binding Kinetics, Conformational Transitions and Domains Interactions....Pages 3-13
Dynamic Aspects of Signal Transfer in Antibody Molecules....Pages 15-29
Could Aggregation of Human Immunoglobulins Bring about Appearance of Novel Antigenic Sites?....Pages 31-44
Introduction....Pages 45-46
Immunoglobulin M Conformational Change is a Signal for Complement Activation....Pages 47-57
Expression of Fc Effector Function in Homogeneous Murine Anti-Ars IgM....Pages 59-72
The Localization of Effector Sites on Immunoglobulin G....Pages 73-81
Human Fcγ Fragment: Location of Acidic Residues Involved in Complement Activation....Pages 83-94
Introduction....Pages 95-96
Ultrastructure of the First Component Of Human Complement....Pages 97-114
Binding of Human I 125 Fibronectin to C1q and to Human Monoclonal Myeloma IgG Subclasses....Pages 115-117
Biochemical Specificity of Human Complement Component C1q....Pages 119-130
Introduction....Pages 131-135
Dissociation of C1 and Concentration Dependence of Its Activation Kinetics....Pages 137-138
Fluid Phase Activation of Proenzymic C1r....Pages 139-140
Activation of Mammalian Complement by Chicken C1q....Pages 141-147
Introduction....Pages 149-154
Conformational Antigenic Determinants in Proteins....Pages 155-156
Topographic Antigenic Determinants Detected by Monoclonal Antibodies to Myoglobin....Pages 157-164
Role of Conformation on the Antigenic Determinants of Tobacco Mosaic Virus Protein....Pages 165-180
Monoclonal Antibodies may Block Sterically or Conformationally the Antigenic Determinants of Human Growth Hormone....Pages 181-190
An Immunochemical Study of the Changes in Conformation Undergone by Two Domains of the Tryptophan-Synthetase β 2 Subunit upon Association....Pages 191-200
Introduction....Pages 201-210
Antibody-Mediated Activation of Genetically Defective Escherichia Coli Galactosidases by Monoclonal Antibodies....Pages 211-212
Synergistic Activation by Monoclonal Antibodies of β-Galactosidase from Genetically Defective E. Coli ....Pages 213-216
Antibodies as Probes of Protein Structure....Pages 217-224
Is There a Preferential Pathway for Antibody-Mediated Enzyme Activation?....Pages 225-231
General Introduction....Pages 233-241
T Lymphocyte Recognition of Small Peptide Antigens: Formation of Neoantigenic Determinants and Clonal Frequency Resulting in IR Gene Control....Pages 243-244
The Antigenic Structure of Bovine Serum Albumin: T-Cell, B-Cell, And Ia Determinants....Pages 247-259
Attempts to Understand the Function of Macrophages and Antigen Specific Cells in their Mutual Interaction....Pages 261-280
A Possible Immunodominant Domain on Myoglobin Recognized by T Lymphocytes....Pages 281-287
Antigen Presenting Function of Macrophages....Pages 289-300
The Sorting-Out Problem in Antigen Presentation....Pages 303-313
Genetic Analysis of Responsiveness to Adjuvant-Free Immunological Signals: Transfer of Genes from Responder Strains (SJL/J And CE/J) to a Nonresponder Background Uncovers a Requirement for H-2 Heterozygosity....Pages 315-321
How is Adjuvanticity Recognised?....Pages 323-336
Specificity and Restriction of T Cells in a System of Complementing Ir Genes....Pages 337-345
Evidence for Ia — Antigen Interaction in T Cell Activation....Pages 349-358
Somatic T Cell Hybrids in the Analysis of H-2 Restriction and Antigen Recognition....Pages 359-360
Introduction....Pages 361-368
Antigen Bridging in T Cell-B Cell Interaction: Fact or Fiction?....Pages 369-371
B Cells as MHC Restricted Antigen Presenting Cells: A Model for T-B Interaction....Pages 373-378
A View from the Bridge: Antigenic Determinants in Immunoregulation....Pages 379-386
Antigen Structures used by Regulatory T Cells in the Interaction among T Suppressor, T Helper and B Cells....Pages 387-394
Activation of Human B Lymphocytes by Antigen Specific T Cell Lines....Pages 395-408
T Helper Cell Recognition of Two Types of Mouse Lambda Light Chains....Pages 409-417
Effects of Anti-Idiotypic Sera (Ab-2) and Monoclonal Idiotypic Antibody (Ab-1) on the Immune Response to a Simple Polypeptide Antigen with only Two Immunologically Active Epitopes. Analysis of the Response at the Unideterminant Level....Pages 419-428
Introduction....Pages 429-440
The Role of IgE and Its Receptor in Mediating Secretion....Pages 441-443
A New Method for Monitoring Intracellular Free Ca 2+ in Lymphocytes. Concanavalin A and Anti-Ig m Induce an Early Rise of Cytoplasmic Free Ca 2+ ....Pages 445-452
B Lymphocyte Stimulation and Suppression by the Fc Portion of Immunoglobulin....Pages 453-458
Modulation of Immunological Reactivity by the Fc Piece of Immunoglobulin....Pages 459-468
T Cell Replacing Factor (TRF)-Induced IgG Production in a Human B Cell Line and the Mechanism of Transmembrane Signaling through TRF-Acceptors....Pages 469-486
Back Matter....Pages 487-498
....Pages 499-505