Proteases II: Potential Role in Health and Disease

Front Matter....Pages i-xvi
Aspartic Proteinases and Inhibitors for their Control in Health and Disease....Pages 1-11
Human Neutral Endopeptidase 24.11 (NEP, Enkephalinase) ; Function, Distribution and Release....Pages 13-21
Neutrophil Elastase and Cathepsin G: Structure, Function, and Biological Control....Pages 23-31
The Degradation of Collagen by a Metalloproteinase from Human Leucocytes....Pages 33-44
Plasma Membrane Proteases as Useful Tool in Histochemical Toxicology....Pages 45-55
Activation of Leukocytes During Prolonged Physical Exercise....Pages 57-63
Inhibition of Human Neutrophil Elastase by Polyguanylic Acid and other Synthetic Polynucleotides....Pages 65-74
Inhibition of Human Neutrophil Elastase by Acid-Soluble Inter-α-Trypsin Inhibitor....Pages 75-82
Development of Eglin c as a Drug: Pharmacokinetics....Pages 83-88
Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology....Pages 89-95
Inhibition of Human Chymotrypsin-Like Proteases by (α 1 -Proteinase Inhibitor and α 1 -Antichymotrypsin....Pages 97-99
Immunoreactive Pancreatic Secretory Trypsin Inhibitor in Gastrointestinal Mucosa....Pages 101-105
Semisynthetic Inhibitors of Human Leukocyte Elastase and their Protective Effect on Lung Elastin Degradation in Vitro....Pages 107-114
Human Bronchial Proteinase Inhibitor: Rapid Purification Procedure and Inhibition of Luecocyte Elastase in Presence and in Absence of Human Lung Elastin....Pages 115-122
Functional Studies of Human Secretory Leukocyte Protease Inhibitor....Pages 123-131
The Role of Chymase in Ionophore-Induced Histamine Release from Human Pulmonary Mast Cells....Pages 133-136
Proteolytic Activities in Bronchoalveolar Lavage Fluid Correlate to Stage and Course of Interstitial Lung Disease....Pages 137-144
Behaviour of Angiotensin Converting Enzyme, Hydroxyproline and some Protease Inhibitors in Pulmonary Sarciodosis....Pages 145-147
Experimental Studies on the Adult Respiratory Distress Syndrome: Elastase Infusion in Normal and Agranulocytic Minipigs....Pages 149-157
Arginylation, Surface Hydrophobicity and Degradation of Cytosol Proteins from Rat Hepatocytes....Pages 159-169
Proteinase Inhibitors as Acute Phase Reactants: Regulation of Synthesis and Turnover....Pages 171-181
Regulation of Proteinase Activity by High Molecular Weight Inhibitors: Biosynthesis of Rat α-Macroglobulins....Pages 183-189
Induction of the Proteinase Inhibitor α 2 -Macroglobulin in Rat Hepatocytes by a Monocyte-Derived Factor....Pages 191-198
Astrocytes Synthesize and Secrete α2-Macroglobulin: Differences Between the Regulation of α2-Macroglobulin Synthesis in Rat Liver and Brain....Pages 199-205
Characterization of Different Forms of Dipeptidyl Peptidase IV from Rat Liver and Hepatoma by Monoclonal Antibodies....Pages 207-214
Non - Lysosomal, High - Molecular - Mass Cysteine Proteinases from Rat Skeletal Muscle....Pages 215-223
Role of Factors Derived from Activated Macrophages in Regulation of Muscle Protein Turnover....Pages 225-234
Responses of Lysosomal and Non-Lysosomal Proteases to Unloading of the Soleus....Pages 235-242
Cathepsin B and D Activity in Human Skeletal Muscle in Disease States....Pages 243-256
Hormonal Regulation of Muscle Protein Catabolism in Acutely Uremic Rats: Effect of Adrenalectomy and Parathyroidectomy....Pages 257-266
Relation Between Urinary Proteinases and Proteinuria in Rats with a Glomerular Disease....Pages 267-273
Characterization and Clinical Role of Glomecular and Tubular Proteases from Human Kidney....Pages 275-282
Effect of Glomerular Proteinuria on the Activities of Lysosomal Proteases in Isolated Segments of Rat Proximal Tubule....Pages 283-291
Meprin Phenotype and Cyclosporin A Toxicity in Mice....Pages 293-304
Potential Role of Lysosomal Proteases in Gentamicin Nephrotoxicity....Pages 305-308
Urinary Proteinase Activity in Patiens with Acute Renal Failure after Trauma and Kidney Transplantation....Pages 309-314
Mechanisms for Activation of Proteolysis in Uremia....Pages 315-321
Evidence for the Role of Proteinases in Uremic Catabolism....Pages 323-329
Eglin C Fails to Reduce Catabolism in Acutely Uremic Rats....Pages 331-337
Evidence for Protein Split Produts in Plasma of Patients with Acute Renal Failure....Pages 339-344
Proteases and Antiproteases at Different Vascular Sites in Renal Failure....Pages 345-349
Protease Histochemistry in Normal and Uremic Rats....Pages 351-360
Total Kininogen Levels, Plasma Renin Activity, Dopamine-Beta-Hydroxylase and Plasma Catecholamines in Chronic and Acute Renal Failure....Pages 361-364
Bioincompatibility of Dialysis Membranes: Factor H Binding Correlates Inversely with Complement Activation Indicating a Local Imbalance of Involved Proteases/Anti-Proteases....Pages 365-375
Hemodialysis with Cuprophane Membranes Leads to Alteration of Granulocyte Oxidative Metabolism and Leukocyte Sequestion in the Lung....Pages 377-384
Effect of Immunosuppresion on the Release of Main Granulocyte Components: In Vivo and in Vitro Studies....Pages 385-389
Release of Granulocyte Proteins During Cardiopulmonary Bypass: Effect of Different Pharmacological Interventions....Pages 391-397
Significant Role of Protease Inhibition by Aprotinin in Myocardial Protection from Prolonged Cardioplegia with Hypothermia....Pages 399-404
Fibrinolysis Caused by Cardio-Pulmonary Bypass and Shed Mediastinal Blood Retransfusion — Is it of Clinical Relevance?....Pages 405-410
Nutrition and Protease Activity....Pages 411-419
Insulin Degradation after Injury in Man....Pages 421-424
Endotoxin Abolishes the Induction of α2-Macroglobulin Synthesis in Cultured Human Monocytes Indicating Inhibition of the Terminal Monocyte Maturation into Macrophages....Pages 425-432
Local and General Defence Mechanisms in Bacterial and Chemical Peritonitis....Pages 433-440
Deficient Phagocytosis Secondary to Proteolytic Breakdown of Opsonins in Peritonitis Exudate....Pages 441-448
Proteolysis and Lipid Peroxidation — Two Aspects of Cell Injury in Experimental Hypovolemic-Traumatic Shock....Pages 449-455
Plasma Levels of Elastase 1 Protease Inhibitor Complex in the Monitoring of ARDS and Multi-Organ Failure — A Summary of Three Clinical Trials....Pages 457-464
PMN Elastase and Leukocyte Neutral Proteinase Inhibitor (LNPI) from Granulocytes as Inflammation Markers in Experimental-Septicemia....Pages 465-471
Plasma Derivative Replacement Therapy in Diss.Intravasc.Coag. (DIC) Induced by Septic Disorders with highly Elevated Elastase α1AT-Complexes....Pages 473-480
Neutrophil Elastase, Thrombin and Plasmin in Septic Shock....Pages 481-484
Elastase-α 1 -Proteinase Inhibitor: An Early Indicator of Septicemia and Bacterial Meningitis in Childhood....Pages 485-491
Serum Pancreatic Secretory Trypsin Inhibitor (PSTI) in Seriously Injured and Septic Patients....Pages 493-498
Changes in PMN-Elastase in Blood and in Renal and Plasma Kallikrein-Kinin Systems after Severe Burn Injury....Pages 499-503
Serum Pancreatic Secretory Trypsin Inhibitor (PSTI) in Patients with Inflammatory Diseases....Pages 505-508
The Effect of Aprotinin Administration on the Intraoperative Histamine Release and Haemostatic Disorders....Pages 509-514
Increased Mortality in Septic Rats after Leupeptin Application....Pages 515-518
Lysosomal Enzymes and Granulocyte Elastase in Synovial Fluid after Multiple Traumatic Injuries....Pages 519-522
A Serine Proteinase Inhibitor in Human Articular Cartilage Possible Role in the Pathogenesis of Inflammatory Joint Diseaeses....Pages 523-530
Detection of Granulocyte Elastase Specific IgG Split Products in Rheumatoid Synovial Fluid....Pages 531-534
The T Cell Specific Serine Proteinase TSP-1: Biochemical Characterization, Genetic Analysis, and Functional Role....Pages 535-545
Pancreatic Secretory Trypsin Inhibitor in Cancer....Pages 547-553
Proteases and Antiproteases in Ascites — Differentiation of Malignant and Nonmalignant Ascites and Prediction of Coagulopathy in Ascites Retransfusion....Pages 555-560
Alpha 1 -Antitrypsin and Alpha 1 -Antichymotrypsin Serum Level in Relation to Staging and Postoperative Clinical Course of Human Colorectal Cancer....Pages 561-564
Inhibition of Proteases During Extracorporeal Extremity Perfusion Experimental and Clinical Results....Pages 565-567
Back Matter....Pages 569-574