Prostate Cancer: Diagnosis and Treatment

Prostate cancer......Page 1
Contents......Page 5
Foreword......Page 7
Key priorities......Page 8
Key research recommendations......Page 9
Recommendations......Page 10
Methodology......Page 18
Algorithms......Page 27
1.2 Incidence......Page 35
1.3 Mortality......Page 37
1.6 Surgery......Page 38
1.9 The Findings of Cancer Peer Review of Urology Cancer Teams in England 2004–2007......Page 39
2.1 Introduction......Page 41
2.2 Communicating with Men with Prostate Cancer, their Partners and Carers......Page 42
2.3 Decision Support......Page 43
2.4 Specific Problems......Page 44
3.1 When to Biopsy......Page 47
3.2 Histological Diagnosis......Page 49
3.3 Staging Classification for Prostate Cancer......Page 50
3.4 Nomograms......Page 54
4.2 Predictive Factors and Risk Groups......Page 57
4.4 Initial Treatment Options......Page 58
4.5 Managing Adverse Effects of Treatment......Page 67
4.6 Follow-up......Page 71
5.2 Defining Biochemical Relapse......Page 76
5.3 Assessment of Biochemical Relapse......Page 77
5.4 Management of Biochemical Relapse......Page 79
6.2 Systemic Therapy......Page 83
6.3 Local Management of Locally Advanced Prostate Cancer......Page 86
7.3 Androgen Withdrawal versus Combined Androgen Blockade (CAB)......Page 90
7.5 Intermittent Androgen Withdrawal......Page 91
7.6 Managing the Complications of Hormonal Therapy......Page 93
7.7 Hormone-Refractory Prostate Cancer......Page 94
7.9 Oestrogens and Steroids......Page 95
7.10 Imaging......Page 96
7.11 Bone Targeted Therapies......Page 97
7.12 Pelvic Targeted Therapies......Page 99
7.13 Palliative Care......Page 100
1 Prostate Specific Antigen (PSA)......Page 104
2 TNM Staging for Prostate Cancer......Page 105
3 An Economic Evaluation of Radical Prostatectomy versus Alternative Treatment Options for Clinically Localised Prostate Cancer......Page 106
4 Abbreviations......Page 116
5 Glossary......Page 118
6 Guideline Scope......Page 127
7 List of Topics Covered by Each Chapter......Page 131
8 People and Organisations Involved in the Production of the Guideline......Page 133
8.1 Members of the Guideline Development Group......Page 134
8.2 Organisations invited to comment on guideline development......Page 139
8.3 Individuals carrying out literature reviews and complementary work......Page 143
8.4 Expert advisers to the Guideline Development Group......Page 145
8.5 Members of the Guideline Review Panel......Page 146