Prostate Cancer: Biology, Genetics, and the New Therapeutics

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Building the Road to Defeat Prostate Cancer....Pages 3-10
Front Matter....Pages 11-11
Hereditary Prostate Cancer....Pages 13-28
AR Gene Alterations in Prostate Cancer Progression....Pages 29-37
Lethal Metastatic Human Prostate Cancer....Pages 39-60
Tumor Suppressor Genes in Prostate Cancer....Pages 61-94
Androgen Receptor Polymorphisms and Prostate Cancer Risk....Pages 95-109
The Genetic Epidemiology of Prostate Cancer....Pages 111-121
Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques....Pages 123-140
Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN)....Pages 141-161
Xenograft Models and the Molecular Biology of Human Prostate Cancer....Pages 163-174
Comprehensive Analyses of Prostate Gene Expression....Pages 175-189
Front Matter....Pages 191-191
The Role of the Nuclear Matrix and Cytoskeleton in Cancer....Pages 193-206
The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis....Pages 207-218
Ligand Dependent and Independent Activation of the Androgen Receptor....Pages 219-239
Tyrosine Kinases and Cellular Signaling in Prostate Cancer....Pages 241-266
Molecular Pathways Underlying Prostate Cancer Progression....Pages 267-277
Angiogenesis and Prostate Cancer....Pages 279-306
Prostate Specific Membrane Antigen....Pages 307-326
Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen-and Chemo-Sensitivity in Prostate Cancer....Pages 327-340
Stromal-Epithelial Interaction....Pages 341-362
Front Matter....Pages 363-363
Chemoprevention of Prostate Cancer....Pages 365-375
Anatomic Radical Retropubic Prostatectomy for Prostate Cancer....Pages 377-386
Radiation Therapy as Applied to Prostate Cancer....Pages 387-413
Prostate Cancer Chemotherapy....Pages 415-431
The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer....Pages 433-447
Development of Dendritic Cell-Based Prostate Cancer Vaccine....Pages 449-459
Antiprogression Agents for Prostate Cancer....Pages 461-481
Human Gene Therapy for Urological Oncology....Pages 483-497
Chemoprevention Trials for Prostate Cancer....Pages 499-518
Back Matter....Pages 519-531