Prostate Cancer: A Comprehensive Perspective

Front Matter....Pages i-xxxi
Front Matter....Pages 1-1
Development, Applied, and Surgical Anatomy of the Prostate....Pages 3-17
Molecular Biology and Prostate Cancer....Pages 19-34
Endocrine Mechanisms, Androgen Receptor and Carcinogenesis, and Hormone Escape....Pages 35-41
Molecular Mechanisms of Castrate Resistant Prostate Cancer....Pages 43-64
Immunologic Aspects of Prostate Cancer....Pages 65-72
Stem Cells in Carcinogenesis of the Prostate....Pages 73-79
Murine Models of Prostate Cancer....Pages 81-106
Prostate Cancer and the Metabolic Syndrome....Pages 107-114
Inflammation and Cancer of the Prostate....Pages 115-122
HIV and Prostate Cancer....Pages 123-134
Prostate Cancer Genetics....Pages 135-146
Gene Expression Profiling and Somatic Genome Changes....Pages 147-155
The Proteomic Approach to Prostate Cancer....Pages 157-167
Epigenetic Changes in Prostate Cancer....Pages 169-179
Biomarkers of Potential Therapeutic Value....Pages 181-187
Prostate Tissue Banking....Pages 189-191
Molecular Imaging in Diagnostics....Pages 193-205
Molecular Risk Profiling....Pages 207-213
Premalignant Lesions of the Prostate....Pages 215-233
The Pathology of Prostatic Carcinoma....Pages 235-262
Front Matter....Pages 1-1
The Pathology of Non-epithelial Tumors of the Prostate....Pages 263-275
Neuroendocrine Prostate Cancer....Pages 277-282
Front Matter....Pages 283-283
Epidemiology of Prostate Cancer....Pages 285-299
Racial Disparities and the Global Picture....Pages 301-310
Natural History of Prostate Cancer....Pages 311-316
Population-based Health Systems as a Foundation for Prostate Cancer Control Research: The Cancer Research Network....Pages 317-331
Screening for Prostate Cancer....Pages 333-346
Next Generation Screening Tests....Pages 347-354
Diet and Prostate Cancer: A Holistic Approach to Management....Pages 355-367
Estrogens in Prostate Cancer....Pages 369-381
Vitamin D and Prostate Cancer....Pages 383-389
The Role of 5α-Reductase Inhibitors (5-ARIs) in Prostate Cancer Chemoprevention....Pages 391-394
Other Pharmaceutical Agents in the Chemoprevention of Prostate Cancer....Pages 395-408
Front Matter....Pages 409-409
Early Detection and Patient Risk Stratification in Prostate Cancer....Pages 411-421
Tumor Markers....Pages 423-444
Prostate Specific Membrane Antigen-Based Diagnostics....Pages 445-457
Prostate Specific Membrane Antigen-Based Therapeutics....Pages 459-466
Presentation and Symptomatology of Prostate Cancer....Pages 467-471
The Role of Ultrasonography....Pages 473-486
The Use of Magnetic Resonance Imaging in the Management of Prostate Cancer....Pages 487-497
Front Matter....Pages 409-409
The Role of Functional Magnetic Resonance Imaging Techniques....Pages 499-510
Prostate Biopsy....Pages 511-524
The Staging of Prostate Cancer....Pages 525-536
Nuclear Medicine in Prostate Cancer....Pages 537-553
Nanotechnology and Prostate Cancer....Pages 555-574
Front Matter....Pages 575-575
Disease Risk Stratification....Pages 577-580
Nomograms in Prostate Cancer....Pages 581-592
Comparative Effectiveness of Treatment Alternatives for Localized Prostate Cancer....Pages 593-605
Front Matter....Pages 607-607
Radical Treatment for Localized Disease: An Overview of Options and Strategies for Decision Making....Pages 609-614
Quality of Life and Management of Localized Disease....Pages 615-619
Active Surveillance for Favorable-Risk Prostate Cancer....Pages 621-629
Anesthesia for Robotic-Assisted Prostatectomy....Pages 631-639
Retropubic Radical Prostatectomy: The Technique....Pages 641-654
Retropubic Radical Prostatectomy: The Results....Pages 655-662
Radical Perineal Prostatectomy....Pages 663-678
Laparoscopic Radical Prostatectomy: The Technique....Pages 679-683
Laparoscopic Radical Prostatectomy: The Results....Pages 685-690
Robotic-Assisted Radical Prostatectomy: The Technique....Pages 691-697
Lymph Node Dissection in Prostate Cancer Surgery....Pages 699-708
External Beam Radiotherapy for Low-Risk Prostate Cancer....Pages 709-717
Front Matter....Pages 607-607
Prostate Brachytherapy: Low Dose Rate....Pages 719-738
Prostate Brachytherapy: High Dose Rate....Pages 739-748
Intensity-Modulated Radiotherapy....Pages 749-759
Proton Beam Therapy and Novel Radiotherapeutic Approaches to the Treatment of Prostate Cancer....Pages 761-771
Prostate Cryotherapy....Pages 773-786
Focal Therapies for Localized Prostate Cancer....Pages 787-803
Front Matter....Pages 805-805
Biochemical Failure in Prostate Cancer....Pages 807-811
The Phenomenon of PSA Bounce After Radiation Therapy....Pages 813-816
Management of Locally Recurrent Disease....Pages 817-829
Management of High-Risk/Locally Advanced Disease....Pages 831-842
Radiotherapy Plus Hormonal Therapy....Pages 843-852
Watchful Waiting in Advanced Prostate Cancer....Pages 853-860
Androgen and Androgen Receptor-Directed Therapy as Initial Treatment for Prostate Cancer....Pages 861-871
Hormone-Based Therapies for Castration-Resistant Prostate Cancer....Pages 873-887
Toxicity of Androgen Deprivation Therapy in Hormone-Sensitive Prostate Cancer....Pages 889-900
Chemotherapy and Novel Systemic Approaches in the Treatment of Metastatic Castration Resistant Prostate Cancer....Pages 901-923
Immunotherapy....Pages 925-934
Bone Health: Prevention of Skeletal-Related Events and Palliative Care....Pages 935-940
Front Matter....Pages 941-941
Assessment of Treatment Outcomes Following Prostate Cancer Therapy....Pages 943-949
Urinary Incontinence....Pages 951-971
Front Matter....Pages 941-941
Erectile Dysfunction....Pages 973-995
Immediate/Early Surgical Complications....Pages 997-1011
Population-Based Outcomes Following Treatment of Clinically Localized Prostate Cancer....Pages 1013-1017
Management of Radiation Adverse Effects....Pages 1019-1027
Management of Complications Following Minimally Invasive Prostate Cancer Therapy....Pages 1029-1037
Front Matter....Pages 1039-1039
Prostate Cancer Emergencies....Pages 1041-1054
Management of Bone Metastases....Pages 1055-1063
Pain Relief in Metastatic Cancer....Pages 1065-1072
The Psychosocial Impact of Prostate Cancer....Pages 1073-1080
Nursing Issues in Prostate Cancer....Pages 1081-1090
Back Matter....Pages 1091-1110