Prostaglandins, Leukotrienes, Lipoxins, and PAF: Mechanism of Action, Molecular Biology, and Clinical Applications

Front Matter....Pages i-xi
Translational Control of Prostaglandin Synthase by Growth Factors and Glucocorticoids....Pages 1-14
Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological Immunological and Molecular Biological Studies....Pages 15-22
A Model for the Transcriptional Regulation of a Mouse PGH Synthase Gene....Pages 23-29
Catalytic Properties and Reaction Mechanism of 5-Lipoxygenase....Pages 31-37
Cloning, Expression and Site-Directed Mutagenesis of the cDNA for Human Placental NAD + -Dependent 15-Hydroxyprostaglandin Dehydrogenase....Pages 39-52
Regulation of Cyclooxygenase Gene Expression in Vascular Endothelial Cells....Pages 53-58
Structure-Function Studies and Physiological Roles of Eicosanoids Metabolized by Cytochrome P450 ω-Hydroxylases....Pages 59-66
Multiple Cyclooxygenases: Cloning of a Mitogen-Inducible Form....Pages 67-78
Amino Acids Essential to Catalysis by Prostaglandin Endoperoxide Synthase....Pages 79-87
Allene Oxide Biosynthesis and Metabolism....Pages 89-96
Lipoxygenase, Cyclooxygenase and Leukotriene A 4 Hydrolase: Quantitative Polymerase Chain Reaction and Expression Studies....Pages 97-105
Annexins and Signal Transduction....Pages 107-122
Structural and Functional Properties of Mammalian Group III Cytosolic Phospholipases A 2 ....Pages 123-134
Regulation of Plasma Membrane Phospholipase A 2 Activity by Phosphorylation/Dephosphorylation: Is Glucocorticoid Action Mediated by Induction of Protein Phosphatase?....Pages 135-139
Eicosanoid/Signal Transduction Interactions: Evidence of Two Induced Pathways of Phosphoinositide Biosynthesis by LTB 4 in Cultured Human Epidermal Cells....Pages 141-151
Prostaglandyl-Inositol Cyclic-Phosphate, A New Second Messenger....Pages 153-168
Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signaling Pathways....Pages 169-175
The Purification of Two Intracellular Phospholipase A 2 s and the Effects of Phospholipase A 2 Activating Protein and Mellitin on Their Activities....Pages 177-185
Differential Regulation of Phospholipase A 2 Activity and Prostacyclin Synthesis in Rat Vascular Smooth Muscle Cells and Cardiomyocytes....Pages 187-198
Thromboxane A 2 /Prostaglandin H 2 Receptors: A Growing Family of Receptor Subtypes....Pages 199-210
The Regulation of Prostacyclin Secretion in Endothelial Cells....Pages 211-223
Metabolism of Arachidonic Acid by Purified Lung Epithelial Cells....Pages 225-232
Recovery of Human Tracheal Cell Epithelial Cell Cyclooxygenase Following Inactivation....Pages 233-240
Aortic Microsomal Prostacyclin Synthesis During Diet Induced Hypercholesterolemia....Pages 241-250
Activation of Protein Kinase C Regulates LTB 4 Receptor on Guinea Pig Eosinophils....Pages 251-267
Novel Neutrophil Agonists: Oxidatively-Fragmented Phosphatidylcholines....Pages 269-279
Specific Binding of Tritium-Labeled Platelet-Activating Factor to Human Mononuclear Leukocyte Membranes: A Third Putative Receptor of Platelet-Activating Factor....Pages 281-294
Tyrosine Kinase Phosphorylation in Human Neutrophil Activation by PAF and other Agonists....Pages 295-308
Platelet-Activating Factor (PAF) Receptor in Brain and Signal Transduction in Neurons....Pages 309-315
Influence of PGE 2 and LTB 4 on CD8 + Thymocytes....Pages 317-327
Modulation of Cytokine Gene Expression by LTB 4 and PAF: Transcriptional and Post-Transcriptional Regulation....Pages 329-334
Hepoxilin A 3 Induces Vascular Permeability in the Skin....Pages 335-338
Lipoxygenase Metabolism in the Regulation of Hematopoiesis....Pages 339-351
Lipid Bodies: Structurally Distinct, Non-Membranous Intracellular Sites of Eicosanoid Formation....Pages 353-362
Tumor Prostaglandins and Estrogen Receptors: Prediction of Survival in Patients with Early Breast Cancer....Pages 363-371
Lipid Mediators in Transplantation Reperfusion Injury, Acute Rejection and Accelerated Transplant Atherosclerosis....Pages 373-381
Pharmacological Profile, Pharmacokinetics and Biotransformation of the 5-Lipoxygenase Inhibitor FLM 5011....Pages 383-397
Prostaglandin H Synthase: Perturbation of the Tyrosyl Radical as a Probe of Anti-Cyclooxygenase Agents....Pages 399-407
Selective Incorporation of Hetes into Epidermal Phospholipids....Pages 409-419
Lipoxin Generation in Human Whole Blood: Monitoring by Electron-Capture NICI GC/MS....Pages 421-430
Therapeutic Aspects of Leukotriene Antagonists and Inhibitors....Pages 431-437
Tolerance to Cardiac Grafts Following Intra-Graft Infusion of 16,16 Dimethyl PGE 2 ....Pages 439-448
Back Matter....Pages 449-461