Prostaglandin and Lipid Metabolism in Radiation Injury

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Radiation Peroxidation in Model Membranes....Pages 3-27
Role of Membrane Lipid Composition in Radiation- Induced Death of Mammalian Cells....Pages 29-43
Influence of Membrane Lipid Composition and Organization on Radio-and Thermosensitivity of Bacteria....Pages 45-57
Role of Membranes, Free Radicals, and Copper in Radiation-Induced Changes in Quaternary Structure of DNA: Some Clinical Implications....Pages 59-72
Role of Lipid Peroxidation in Radiation Damage and Repair of Cell Membranes in the Thermophilic Bacterium Thermus Thermophilus ....Pages 73-77
Macromolecule Effects on Prostacyclin Production and Measurement....Pages 79-83
Inositol Lipid Turnover, Ca 2+ Mobilization, and Increased Ca 2+ Influx in Heat-Stressed Cells....Pages 85-90
Role of Antioxidant Nutrients in Preventing Retinal Damage During Hyperbaric Oxygen Treatment....Pages 91-95
Effects of Phenylhydrazine on Human Red Cell Membrane Aminophospholipids: A Fluorescamine Study....Pages 97-101
Role of Oxygen Radicals in Peroxidation of Docosahexaenoic Acid by Rat Brain Homogenate in vitro ....Pages 103-108
Possible Involvement of Queuine in Oxidative Metabolism....Pages 109-114
Cytochrome P-450 Interaction with Arachidonic Acid Hydroperoxides: Role in Lipid Peroxidation....Pages 115-119
Leakage of Fatty Acid Radicals During Lipoxygenase Catalysis....Pages 121-126
The Mast Cell Granule: A Phospholipid Source for Prostaglandin Synthesis....Pages 127-132
Front Matter....Pages 133-133
Studies on Effect of Gamma Radiation on Prostacyclin and Platelet-Activating Factor Synthesis and on Cell Growth Using Smooth Muscle, Fibroblast, and Endothelial Cells in Cultures....Pages 135-146
Prostacyclin and Thromboxane Production by Irradiated Rat Lung....Pages 147-158
Eicosanoid Changes in Skin Following Ultraviolet Light Irradiation....Pages 159-171
Leukotriene Synthesis by UV-Irradiated Macrophage Cell Cultures....Pages 173-178
Influence of Psoralen and Ultraviolet Therapy on Platelet Function and Arachidonic Acid Metabolism in Patients with Vitiligo....Pages 179-183
Sources of Increased in vivo Cyclooxygenase Product Release Following Whole-Body Irradiation of Rats....Pages 185-199
Front Matter....Pages 133-133
Thermal Injury Causes Stimulation of Phospholipase A 2 Activity in Mammalian Cells....Pages 201-206
Effects of Neutron Irradiation on PGE 2 and TxB 2 Levels in Biological Fluids: Modification by WR-2721....Pages 207-218
Thromboxane and Prostacyclin Production by Irradiated and Perfused Rat Kidney....Pages 219-224
Generation of a Neutrophil Chemoattractant of the Lipoxygenase Pathway by Irradiated Bovine Aortic Endothelial Cells....Pages 225-230
Front Matter....Pages 231-231
Radiation Protection by Exogenous Arachidonic Acid and Several Metabolites....Pages 233-243
Alterations in Locomotor Activity Induced by Radioprotective Doses of 16,16-Dimethyl Prostaglandin E 2 ....Pages 245-251
Effect of PGE 2 on Radiation Response of Chinese Hamster V79 Cells in Vitro ....Pages 253-262
A Paradoxical Role for Eicosanoids: Radioprotectants and Radiosensitizers....Pages 263-271
Front Matter....Pages 273-273
Eicosanoids and Elective Immunosuppression....Pages 275-281
Prostaglandins and Hemopoietic Cell Recovery Following Irradiation....Pages 283-292
Ionizing Radiation, Prostaglandins, and Gastric Function in Monkeys....Pages 293-303
Changes in Renal Blood Flow, Glomerular Filtration, and Vasoactive Hormones in Bone-Marrow-Transplant Recipients After Total-Body Irradiation....Pages 305-317
Eicosanoids and Radiotherapy in Human and Animal Tumors....Pages 319-330
Modification of Radiation Injury of Murine Intestinal Clonogenic Cells and B-16 Melanoma by PGI 2 or Flurbiprofen....Pages 331-338
Influence of UV Light (250 nm) on Platelet Activation....Pages 339-343
Effects of Eicosanoid Precursors on TBA Reactive Material in Normal and Malignant Cells....Pages 345-352
Front Matter....Pages 353-353
Development of Enzyme-Immunoassay Techniques for Measurement of Eicosanoids....Pages 355-364
Detection and Quantitation of Eicosanoids by Combined Gas Chromatography-Mass Spectrometry....Pages 365-377
Lipid Peroxidation and Its Measurement....Pages 379-386
An in Situ Method for Detection of Lipid Peroxidation Effects....Pages 387-391
Front Matter....Pages 353-353
Effects of Ultraviolet Light Irradiation, Carbon Tetrachloride, and Trichloroethylene on Ethane Exhalation in Rats....Pages 393-401
A Sensitive and Selective Method for Quantitative Analysis of Products of Lipid Peroxidation....Pages 403-409
Back Matter....Pages 411-420