Progress in Iron Research

Front Matter....Pages i-ix
Mechanism of Fe(II) Oxidation and Core Formation in Ferritin....Pages 1-12
Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin....Pages 13-21
Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins....Pages 23-30
The Transferrin Receptor and the Release of Iron from Transferrin....Pages 31-40
The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages....Pages 41-50
Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition....Pages 51-59
Mechanism of Production of the Serum Transferrin Receptor....Pages 61-68
Iron Absorption and Cellular Uptake of Iron....Pages 69-79
Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts....Pages 81-89
Cellular Responses to Iron and Iron Compounds....Pages 91-100
The Structure and Function of Iron Regulatory Factor....Pages 101-109
Structure and Function of Ires, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase....Pages 111-118
Translational Control by Iron-Responsive Elements....Pages 119-126
The Role of Cytokines in the Regulation of Ferritin Expression....Pages 127-132
Stimulation of IRE-BP Activity of IRF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase....Pages 133-139
Reciprocal Modulation of Aconitase Activity and RNA-Binding Activity of Iron Regulatory Factor by Nitric Oxide....Pages 141-148
A New Look at Ferritin Metabolism....Pages 149-156
Bacterioferritin: A Hemoprotein Member of the Ferritin Family....Pages 157-164
Intracellular Iron....Pages 165-171
Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation....Pages 173-187
Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells....Pages 189-197
Differential Effects of Iron and Iron Carrier on Hematopoietic Cells Differentiation and Human Ada Gene Transfer....Pages 199-210
A Hemin-Inducible Enhancer Lies 4.5 Kb Upstream of the Mouse Ferritin H Subunit Gene....Pages 211-218
Iron Deficiency: The Global Perspective....Pages 219-228
Iron Regulation in the Brain at the Cell and Molecular Level....Pages 229-238
Pathophysiology of Iron Toxicity....Pages 239-253
Morphologic Observations in Iron Overload: An Update....Pages 255-265
Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells....Pages 267-276
Iron Overload and the Biliary Route....Pages 277-283
Changing Concepts of Haemochromatosis....Pages 285-291
Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis....Pages 293-302
The Morbidity of Hemochromatosis among Clinically Unselected Homozygotes: Preliminary Report....Pages 303-308
Genetics of Haemochromatosis....Pages 309-318
Localization of Seven New Genes Around the HLA-A Locus....Pages 319-330
Searching for the Hemochromatosis Grail....Pages 331-342
Iron Chelator Design....Pages 343-349
Results from a Phase I Clinical Trial of HBED....Pages 351-359
Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds....Pages 361-370
Iron Chelation Therapy for Malaria....Pages 371-383
The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells....Pages 385-397
Back Matter....Pages 399-402