Progress in Immunology: Vol. VII: Proceedings of the 7th International Congress Immunology Berlin 1989

Front Matter....Pages I-CI
Front Matter....Pages 1-1
T Cell Receptors....Pages 3-12
Positive and Negative Selection of T Cells: A Transgenic Model....Pages 13-15
Selection of an αβ T Cell Antigen Receptor In Vivo and Engineering a Solulizable Form....Pages 16-21
Mice Transgenic for the T Cell Receptor C γ 4 Gene are Altered in T Cell Development....Pages 22-28
Lymphocytes Bearing Either γδ -TCR or αβ -TCR Can Recognize Non-MHC Encoded CD1 Molecules....Pages 29-32
Assembly of the T Cell Receptor/CD 3 Complex....Pages 33-39
Structural and Functional Analysis of Human Class I and Class II Major Histocompatibility Complex Proteins, with Special Emphasis on Alloreactivity....Pages 43-51
Further Analysis of the Role of MHC Molecules in Antigen Presentation....Pages 52-59
Studies on the Nature of Physiologically Processed Antigen....Pages 60-67
Role of MHC Polymorphism in Autoimmune Disease....Pages 68-75
Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression....Pages 76-80
Organization and Reorganization of Antigen Receptor Genes....Pages 83-91
The Human Immunoglobulin Kappa Genes....Pages 92-98
Somatic Changes in the Immune Response to the Hapten 2-Phenyl Oxazolone....Pages 99-105
The Lymphoid V(D)J Recombination Activity: Studies of Exogenous Plasmid Substrates in Whole Cells....Pages 106-113
Early Expression of Ig-Related Genes in the Human B-Cell Lineage....Pages 114-117
Adhesion Receptors Regulate Antigen-Specific Interactions, Localization, and Differentiation in the Immune System....Pages 121-130
From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation....Pages 131-138
The T-Cell Antigen Receptor and CD2 in Rat T-Cell Activation and Ontogeny....Pages 139-146
Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies....Pages 147-155
Front Matter....Pages 1-1
A Lymphocyte Homing Receptor: A Member of an Emerging Class of Cell Adhesion Molecules....Pages 156-160
Introduction to the Symposium on Complement....Pages 163-170
The Regulators of Complement Activation (RCA) Gene Cluster....Pages 171-177
Host Cell Protection from Complement by Glycosyl-phosphatidylinositol-Anchored Complement Inhibitors and Their Deficiencies in Paroxysmal Nocturnal Hemoglobinuria....Pages 178-185
Inflammation-Promoting Complement Fragments....Pages 186-193
Evasion Strategies of Microorganisms....Pages 194-201
Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators....Pages 202-204
Protein Phosphorylation as a Mechanism of Resistance Against Complement Damage....Pages 205-208
The Mosaic Nature of the Complement Proteins....Pages 209-212
Front Matter....Pages 213-213
The Role of the Thymus in the Development of T-Cells....Pages 215-221
Ontogeny of T Cells and a Third Lymphocyte Lineage in the Chicken....Pages 222-228
Analysis of Hematopoietic Stem Cell Development In Vivo....Pages 229-234
Utilization of a Bone Marrow Suspension Culture System for the Analysis and Manipulation of T-Cell Development....Pages 235-242
Diversity, Development, Ligands and Probable Functions of γδ T Cells....Pages 243-257
Thymic Epithelial Cells Induce in Vitro Differentiation of PRO-TLymphocyte Clones into TCR α, β /CD3 + and TCR γ , δ /CD3 + Cells....Pages 258-262
Selection of the T Cell Repertoire in the Thymus....Pages 265-273
T Cell Differentiation in Lower Vertebrates....Pages 274-281
Participation of CD4 and CD8 Accessory Molecules in the Development and Selection of T Lymphocytes....Pages 282-288
Development of the T Cell Repertoire: Contributions of Both TCR-MHC and Accessory Molecule-MHC Interactions....Pages 289-296
Self-Nonself Discrimination by the Immune System....Pages 297-301
Front Matter....Pages 213-213
Development and Regulation of the B Lymphocyte Lineage: An Interpretive Overview....Pages 305-315
Control of Expression of Immunoglobulin Genes....Pages 316-323
Regulation of Immunoglobulin Gene Rearrangement....Pages 324-330
Isolation and Characterization of Hematopoietic Stem Cells and Progenitors....Pages 331-338
Structure, Control of Expression and Putative Function of the PreB Cell-Specific Genes V preB and λ 5 ....Pages 339-347
B Cell Differentiation: Development of Antibody Repertoires....Pages 351-360
Evolution of Immunoglobulin Gene Complexity....Pages 361-368
Are Autoreactive B Cells Deleted?....Pages 369-376
Self-Tolerance in B-Cells from Different Lines of Lysozyme Double-Transgenic Mice....Pages 377-384
The Recombination Activating Gene and Lymphoid Differentiation....Pages 385-388
Repertoire Selection in B Cell Subpopulations....Pages 389-393
Evolutionary and Somatic Immunological Memory....Pages 397-403
Development of the B Cell Repertoire and the Ability to Respond to Bacteria Associated Antigens....Pages 404-408
B Cell Lineages and Immunologic Memory....Pages 409-414
The Influence of Somatic Mutation on Clonal Expansion....Pages 415-423
Self-Nonself Discrimination by Precursors of Memory B Cells....Pages 424-431
Identification of Human Naive and Memory T Cells....Pages 432-438
Characterization of the Secondary Antibody Response Using Purified Memory B and T Cells....Pages 439-442
The Production and Selection of Memory B Cells in Follicles....Pages 443-447
Tumors of Lymphoid and Myeloid Cells: Introduction....Pages 451-463
Front Matter....Pages 213-213
The Ig/myc Translocation in Burkitt’s Lymphoma Is a Rate Limiting Step in Tumor Development with Multiple Phenotypic Consequences....Pages 464-473
The Development of B-Lymphomas in the Chicken....Pages 474-478
Bcl-2 α Encodes a Novel Small Molecular Weight GTP Binding Protein....Pages 479-488
Role of the Bcl-2 Proto-Oncogene in Neoplasia....Pages 489-493
Transgenic Mice as Models for the Development of Haemopoietic Neoplasia....Pages 494-501
Tumor Suppression in Somatic Cell Hybrids Between Burkitt’s Lymphoma Cells and EBV-Immortalized Lymphoblastoid Cells....Pages 502-505
Primary Immunodeficiencies: Current Findings and Concepts....Pages 509-518
X Chromosome Inactivation Analysis: A New Tool to Examine X-Linked Immunodeficiencies....Pages 519-526
Nature of the Defect in the Scid Mouse Mutant....Pages 527-534
The Wiskott-Aldrich Syndrome and CD43....Pages 535-538
The Leukocyte Adhesion Deficiency....Pages 539-543
Genotypic Studies of MHC Class III Genes in Individuals with IgA Deficiency and Common Variable Immunodeficiency....Pages 544-546
Mapping of Two IgCH Gene Deletions in a Patient with IgG1 Deficiency....Pages 547-550
Front Matter....Pages 551-551
Cellular Cooperation in Antibody Production....Pages 553-560
Clonal Deletion of Autoreactive T Lymphocytes: Insights from Neonatal Ontogeny....Pages 561-566
Developmental Arrest of T Cell Receptor (TcR) Negative SCID Thymocytes and Release in the Presence of TcR + Cells....Pages 567-571
Costimulatory Interactions Determine Proliferation Versus Induction of Clonal Anergy During Type I CD4 + T-Cell Stimulation....Pages 572-580
Signal Requirements for the Primary Activation of Murine CD8 T Lymphocytes....Pages 581-586
Contact with Helper T Cells Does Not Limit the Induction of Resting B Cell Differentiation....Pages 587-592
Clonal Expansion and Differentiation to Effector Function in Normal CD4 T Cell Subpopulations....Pages 593-597
Front Matter....Pages 551-551
Structure and Function of Lymphokines and Their Receptors....Pages 601-610
Heterogeneity of Mouse Helper T Cells and Cross-Regulation of TH1 and TH2 Clones....Pages 611-618
Interleukin 2 Receptor Targeted Immunotherapy — Update and Attempt at Synthesis....Pages 619-626
Molecular Analysis of the Interleukin-2 Receptor Complex: Expression of the Human α and β Chain cDNAs....Pages 627-632
Interleukin 6 and Its Receptor in Immune Regulation....Pages 633-640
The Molecular and Cellular Biology of the IFN γ Receptor....Pages 641-648
Membrane Immunoglobulins Are Associated with a Family of Membrane Phosphoproteins....Pages 651-658
Molecular Components of the IgM Antigen Receptor Complex....Pages 659-662
Membrane Immunoglobulin Is Associated with a Phosphoprotein Complex....Pages 663-668
Signalling via Surface Immunoglobulin, Fcγ and Interleukin-4 Receptors on B Lymphocytes....Pages 669-675
Is There Specificity Involved in Fcε Receptor Aggregation Which Leads to an Effective Secretory Stimulus?....Pages 676-682
The Association of p56 lck with the CD4/CD8 Antigens: Implications for T-Cell Function....Pages 683-686
Signal Transduction by the T Cell Antigen Receptor....Pages 687-692
Molecular Biology of Mast Cell Secretory Granule Proteoglycans and Proteases....Pages 695-700
Differentiation of Mast Cells and Phenotypic Change Between Subpopulations....Pages 701-708
Nerves, Neuropeptides and Mast Cells....Pages 709-715
The High Affinity Receptor for Immunoglobulin E: New Developments....Pages 716-723
FcεR2/CD23: Regulation and Functional Roles in Cell Activation....Pages 724-731
Human Eosinophils: Synthesis and Expression of CD4 and Class II MHC Proteins....Pages 732-735
Effector Function of Eosinophils: Isotype-Dependent Activation....Pages 736-743
Front Matter....Pages 551-551
Endothelial Activation and Inflammation....Pages 747-753
Pathogenesis of Tissue Fibrosis: Growth Factor Gene Expression in Mononuclear Phagocytes....Pages 754-760
Inflammation and Angiogenesis....Pages 761-764
Novel Neutrophil-Activating Peptides and Their Role in Inflammation....Pages 765-771
Neuromediators of Immunity and Inflammation....Pages 772-779
Cytokine Induced Changes in the Endothelial Cell Surface Membrane: Significance for Lymphocyte Traffic in Inflammation....Pages 780-783
Paul Ehrlich and the Foundations of Autoimmunity....Pages 787-792
The Physiology of Autoimmune Reactivities....Pages 793-804
Reverse Immunogenetics: Investigations of HLA-Associated Disease Based on the Structural and Genetic Identification of Candidate Susceptibility Genes....Pages 805-812
Autoimmunity in the Nervous System: Functional Properties of an Encephalitogenic Protein....Pages 813-820
Inflammatory Destruction of Pancreatic Islets in Interferon Gamma Transgenic Mice....Pages 821-825
Tolerance in Transgenic Mice to a Non-MHC Self-Protein is not a Result of Clonal Deletion....Pages 826-832
Autoabzyme Catalyzed Cleavage of Vasoactive Intestinal Peptide....Pages 833-836
Evidence Suggesting a Retroviral Etiology for Human Autoimmune Disease....Pages 837-841
Is Genes in the Mouse....Pages 845-852
Differential Roles of HLA-DR and DQ in Immune Regulation....Pages 853-860
Role of the Veto Phenomenon In Vivo....Pages 861-866
T Cell Vaccination and Suppression of Autoimmune Disease....Pages 867-873
Antigen Specific Suppressor Cells, Receptors, and Factors....Pages 874-881
Extrathymic Acquisition of Tolerance by T Lymphocytes: Is Suppression Involved?....Pages 882-889
Front Matter....Pages 551-551
Antigen Specific T Cell Nonresponsiveness in Man: Lepromatous Leprosy, a Model Disease....Pages 890-893
Front Matter....Pages 895-895
CD4+ and CD8+ T Cells in Murine Virus Infections: Experiments with Lymphocytic Choriomeningitis and Influenza....Pages 897-905
Immune-Protection Versus Immunopathology by Antiviral T Cell Responses....Pages 906-913
Recognition of Viral Antigens by Cytotoxic T Lymphocytes....Pages 914-921
Blockade of MHC Class I Molecule Transport from the Endoplasmic Reticulum Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes....Pages 922-930
Measlesvirus-Induced Cellular Autoimmune Reactions....Pages 931-938
Requirements for Recognition of Epstein-Barr Virus-Infected Target Cells by Human Cytotoxic T Lymphocytes....Pages 939-945
Molecular Analysis of the Protective Immune Response to Murine Cytomegalovirus....Pages 946-953
Insights into Immunoregulation and Pathogenesis from a Third World Disease....Pages 957-962
Effector T Cells in Bacterial Infections....Pages 963-970
Experimental Infection of Mice with Leishmania Major: Analysis of the Role of T Cells in Resistance and Susceptibility....Pages 971-978
Progress Towards Vaccination Against Schistosomiasis....Pages 979-987
Antigenic Diversity: Implications for Vaccine Design....Pages 988-993
Genetic Aspects of Mycobacterial Infections in Mouse and Man....Pages 994-1001
An Introduction into the Immunology of AIDS....Pages 1005-1015
Genetic Regulation of HIV....Pages 1016-1020
The Role of CD4 Antigen in HIV Infection....Pages 1021-1027
Immunopathogenic Mechanisms of HIV Infection....Pages 1028-1035
Immunobiology of the HIV Envelope and its Relationship to Vaccine Strategies....Pages 1036-1045
The SCID-hu Mouse: A Small Animal Model for HIV Infection and Antiviral Testing....Pages 1046-1049
Front Matter....Pages 895-895
Structural Basis for Tumor Cell Recognition by the Immune System....Pages 1053-1062
Genes Coding for TUM - Transplantation Antigens. A Model for TSTA?....Pages 1063-1070
Regulation and Functional Role of MHC Expression on Tumors....Pages 1071-1078
Immunological Analysis of Micrometastases and the Metastatic Phenotype of Human Tumors....Pages 1079-1086
Basic Aspects of Immunotherapy of Human Tumors....Pages 1087-1096
T Cell-Mediated Tumor Regression in Experimental Systems....Pages 1097-1103
Apoptosis in Monoclonal Antibody-Induced Tumor Regression....Pages 1104-1105
Front Matter....Pages 1107-1107
An Introduction to Vaccines: An Old Problem in a New Setting....Pages 1109-1114
High Degeneracy of HLA DR-Peptide Interactions: Possible Ramifications for Vaccine Design....Pages 1115-1122
T and B Cell Recognition of Hepatitis B Viral Antigens: Implications for Vaccine Design....Pages 1123-1130
Vaccinia Virus Vectors: Applications to Vaccines....Pages 1131-1136
Peptide Binding to MHC Class II Molecules: Applications to Vaccine Design....Pages 1137-1143
Expression and Secretion of Repertoires of VH Domains in Escherichia Coli : Isolation of Antigen Binding Activities....Pages 1144-1151
Prospects for Transplantation....Pages 1155-1162
Antigen, Cytokines, and the Regulation of the Allograft Response....Pages 1163-1170
Mixed Chimerism and Transplantation Tolerance....Pages 1171-1176
Pathology and Immunopathology of Rejection and Graft-Versus-Host Disease in Bone Marrow Transplantation....Pages 1177-1184
Graft Host Interactions Following T-Cell Depleted Marrow Transplants....Pages 1185-1194
Rapamycin: A New and Highly Active Immunosuppressive Macrolide with an Efficacy Superior to Cyclosporine....Pages 1195-1198
IL-2 Receptor-Directed Immunotherapy: A Model of Immune Intervention....Pages 1201-1212
Front Matter....Pages 1107-1107
Cytokine Therapy of Patients with Cancer....Pages 1213-1220
Modulation of Autoimmune Responses with Normal Polyspecific IgG for Therapeutic Use....Pages 1221-1227
Biological Response Modification of “Physiological” Doses of Recombinant Cytokines....Pages 1228-1233
The Evolution of the Immune System: An Introduction....Pages 1237-1239
Protein-Protein Interactions and Immune Recognition....Pages 1240-1245
Evolutions of the Immune System....Pages 1246-1255
Allorecognition in Colonial Tunicates: Parallels with and Tangents from Vertebrate Immunity....Pages 1256-1263
Elements of the Human Immune System: Studies of Mature Lymphoid Cells Following Xenotransplantation to Scid Mice....Pages 1264-1271
The Regulation of Lymphopoiesis by Interleukin-7....Pages 1272-1275
Expression of T Cell Receptor Associated Proteins During Human T Cell Development....Pages 1276-1279
Back Matter....Pages 1281-1320