Progress in Immunology Vol. VIII

Front Matter....Pages I-LXII
Front Matter....Pages 1-1
Immunological Tolerance Revisited in the Molecular Era....Pages 3-9
Birth, Life and Death of a B Cell....Pages 11-19
Germinal Centres in the Affinity Maturation of T Cell-Dependent Antibody Responses....Pages 21-26
Structure and Function of the B Cell Antigen Receptors....Pages 27-33
Receptor Editing in Immature Self-Reactive B-cells....Pages 35-42
A Developmental Switch in B Lymphopoiesis: A Fetal Origin for CD5 + B Cells....Pages 43-49
The Role of bcl — 2 in Lymphoid Differentation and Transformation....Pages 51-56
Control of the T Cell Repertoire....Pages 57-63
Tolerance, Autoimmunity and Immunopathology....Pages 65-72
T Cell Receptor Signalling Defects in Anergic T Cell Induced in vivo by Bacterial Superantigen....Pages 73-80
Intrathymic Selection and Maturation of αβ T Cells....Pages 81-88
Front Matter....Pages 89-89
Organization of the Human Immunoglobulin Heavy-Chain Locus....Pages 91-97
Restricted V H Gene Usage and Generation of Antibody Diversity in Rabbit....Pages 99-106
Evolutionary Origins of Immunoglobulin Gene Diversity....Pages 107-114
The Human Immunoglobulin κ Locus: Facts and Artifacts in Establishing a PFGE Map....Pages 115-119
Diversity Is Generated with Diversity....Pages 121-128
Exclusion and Inclusion of α and β T Cell Receptor Alleles in Different T Cell Lineages....Pages 129-133
Front Matter....Pages 135-135
The Accordion Model of Mhc Evolution....Pages 137-143
Are Medial Class I Histocompatibility Antigens Coming of Age?....Pages 145-152
 Trans- species Polymorphism of the Major Histocompatibility Complex ( Mhc ) Loci....Pages 153-158
Front Matter....Pages 135-135
A Cellular Travelogue Major Highways, Secret Hideouts, Spa Cuisine....Pages 159-166
Peptide Binding and Intracellular Transport of MHC Molecules....Pages 167-173
The Kinetics of Association of Peptides with MHC Class 1 Molecules....Pages 175-180
Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex....Pages 181-188
Peptide Binding to MHC Class II Molecules in Living Cells: Role of Class II Synthesis and Stability of Peptide/Class II Complexes....Pages 189-195
Front Matter....Pages 197-197
B Cell Antigen Receptor Ligation Activates a Receptor Associated Protein Tyrosine Kinase....Pages 199-204
Molecular Dissection of T-Cell Antigen Receptor Signal Transduction....Pages 205-211
A Diversity of Protein Tyrosine Phosphatases Expressed by T Lymphocytes....Pages 213-219
Antigen Receptors Clustering; Mobility, Size and Configurational Requirements for Effective Cellular Triggering....Pages 221-228
Front Matter....Pages 229-229
Interrelationships of Peripheral T Cell Subsets....Pages 231-238
Human Th1 and Th2 Cells:Regulation of Development and Role in Protection and Disease....Pages 239-245
Differential Regulation of Murine T Lymphocyte Subsets....Pages 247-254
T-cell Mediated Cytotoxicity....Pages 255-259
Development of TCR γ δ Cells....Pages 261-265
Front Matter....Pages 267-267
Cell Interaction Molecules Regulating T Cell Receptor Mediated Signal Transduction: A Comparison of Peripheral T Cell with Developing Thymocytes....Pages 269-274
The Role of Co-receptors in T Cell Activation....Pages 275-281
Integrins and their Activation....Pages 283-288
CD44 in Normal Differentation and Tumor Progression....Pages 289-293
Front Matter....Pages 295-295
The Cytokine Network: Contributions of Proinflammatory Cytokines and Chemokines....Pages 297-304
Lymphocyte Development and Immunoreactivity in IL-2 Deficient Mice....Pages 305-311
Front Matter....Pages 295-295
Biology of Interleukin 9 and its Receptor....Pages 313-319
The IL-2 Receptor and its Target Genes in Hematopoietic Cell Cycle....Pages 321-326
Biological Roles of IL-10 and the CD40 Receptor....Pages 327-332
Cytokine Receptor Directed Therapy with Genetically Engineered Monoclonal Antibodies Armed with Radionuclides....Pages 333-338
Blocking Interleukin-1 in Disease....Pages 339-346
IL-4 is a Major Determinant of T Cell Lymphokine-Producing Phenotype....Pages 347-354
Interleukin 10 and the Inflammatory Response....Pages 355-360
Cytokine Gene Transfer into Tumor Cells and its Application to Human Cancer....Pages 361-367
Molecular Mechanisms for the Regulation of Inflammation....Pages 369-376
Liver as a Target of Inflammatory Mediators....Pages 377-384
Interleukin — 8 and Related Cytokines....Pages 385-392
Front Matter....Pages 393-393
New Trends in Allergy....Pages 395-402
T Lymphocyte/Eosinophil Interactions in Atopic Asthma: Critical Role for Interleukin-5....Pages 403-410
Cytokines in allergic inflammation....Pages 411-418
Control of IgE and Cytokine Responses....Pages 419-426
Molecular Analysis of House Dust Mite Allergens....Pages 427-433
Recent Advances in the Field of High Affinity IgE Receptors: the Connection to Signal Transduction....Pages 435-440
Front Matter....Pages 441-441
The Regulation and Functional Significance of Fc Receptors on Murine Lymphoid Cells: The Special Case of T Cells....Pages 443-449
Identification of Functionally Active Regions of Fcγ RII and Fc ε RI....Pages 451-456
Structures Involved in the Activities of Murine Low Affinity Fcγ Receptors (FcγR)....Pages 457-464
Front Matter....Pages 441-441
The CD23 Multifunctional Molecule and its Soluble Fragments (IgE-Binding Factors or Soluble CD23)....Pages 465-472
Signal Transduction by the Receptor with High Affinity for IgE....Pages 473-480
Front Matter....Pages 481-481
Tissue Specific Complement Gene Expression: Evidence for Novel Functions of the Complement Proteins....Pages 483-493
Mediating B Lymphocyte Activation by the CR2/CD19 Complex....Pages 495-499
Molecular Mimicry in the Pathogenicity of Microorganisms....Pages 501-508
The Role of Complement in Enhancing Infection of Target Cells with Human Immunodeficiency Virus....Pages 509-516
Evolution and Genetic Regulation of Complement C3 and C4 Genes....Pages 517-523
Complement System Genes and the Structures of the Proteins They Encode....Pages 525-532
Front Matter....Pages 533-533
Antibody Deficiencies Reflect Abnormal B Cell Diffrentiation....Pages 535-543
X-Linked Agammaglobulinemia: Updated Criteria for Diagnosis....Pages 545-552
Gene Therapy for Immunodeficiency and Cancer....Pages 553-555
Severe Combined Immunodeficiencies in Humans....Pages 557-560
Knock out Mice Models for Immunodeficiency Diseases....Pages 561-570
Front Matter....Pages 571-571
T Cell Epitopes of Synthetic Antigens and of Antigens Related to Autoimmune Diseases....Pages 573-578
Autoimmunity to a Heat Shock Protein Probes the Immunological Homunculus....Pages 579-586
Inhibition of Autoimmune T cells by “Competitor-Modulator” peptides....Pages 587-594
Cellular Levels of Expression of Genes Coding for Organspecific Autoimmune Diseases....Pages 595-602
Physiopathology of Autoimmunity: The Reactivities of Natural Antibodies Define the Boundaries of the Immunological Self....Pages 603-610
Front Matter....Pages 611-611
Regulation of Regulatory T Cells....Pages 613-618
Therapeutic Anti-clonotypic Vaccines....Pages 619-626
Front Matter....Pages 611-611
Suppression of Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens....Pages 627-634
TCR Peptide Therapy in Autoimmunity....Pages 635-641
Suppression of Autoimmunity through Manipulation of Immune Network with Normal Immunoglobulin G....Pages 643-649
Control of Fertility by Immunisation with Antiprogesterone Antiidiotypes....Pages 651-656
Front Matter....Pages 657-657
Viruses Escaping Immunological Surveillance....Pages 659-666
Immune Avoidance by Pathogenic Neisseria ....Pages 667-674
Escape Mechanisms in Schistosomiasis....Pages 675-682
Can New Vaccines Overcome Parasite Escape Mechanisms?....Pages 683-689
HIV and Human Complement: Molecular Mechanisms and Biological Consequences....Pages 691-698
B Cell Activation and HIV-1 Infection....Pages 699-706
TH1 and TH2 Type Responses in HIV Infection....Pages 707-724
HIV-1 Strain-dependent CD4 T Cell Depletion in hu-PBL-SCID Mice....Pages 725-730
Immune Response Regulations in Parasitic Infections....Pages 731-738
A Vaccine Against Schistosomiasis: Strategy and Perspectives....Pages 739-745
Correlation of Natural Killer Cell Activation, CD4+ TH1 Cell Development and resistance in Experimental Cutaneous Leishmaniasis....Pages 747-752
Recombinant Migration Inhibitory Factor (MIF): its Potential as an Adjuvant for Developing Vaccines....Pages 753-759
Still Learning from Leprosy....Pages 761-766
Development of Synthetic Vaccines....Pages 767-774
The Analysis of the Function and Specificity of T Cells Triggered During Infection with Leishmania , Its Importance for the Rational Design of a Vaccine....Pages 775-782
Front Matter....Pages 783-783
MHC Restricted Allorecognition as a Modulator of the Homograft Reaction....Pages 785-791
Front Matter....Pages 783-783
Quantitation and Manipulation of Alloimmune Responses....Pages 793-800
T Cell Subsets Resisting Induction of Mixed Chimerism Across Various Histocompatibility Barriers....Pages 801-805
Temporary Tolerance or Suppressive Regulation Induced By Non MHC Alloantigens in Transplantation and Pregnancy....Pages 807-814
Xenotransplantation of Neovascularised Endocrine Tissue in Autoimmune Diabetes....Pages 815-822
Front Matter....Pages 823-823
Reproductive Immunology 1989–1992: Some Important Recent Advances about Feto Maternal Relationship....Pages 825-832
Maternal Responses to Trophoblast Antigens: Idiotype-Antiidiotype Control....Pages 833-840
Role of a Unique Species of Transforming Growth Factor Beta in Preventing Rejection of the Conceptus During Pregnancy....Pages 841-847
Vaccines for Control of Fertility....Pages 849-856
The Role of Placental IL-10 in Maternal-Fetal Immune Interactions....Pages 857-859
Immuno-Endocrine Networks in Pregnancy....Pages 861-868
Front Matter....Pages 869-869
Genes Coding for Tumor Rejection Antigens....Pages 871-876
The Immunological Basis of Active Specific Immunotherapy (ASI) for Human Melanoma....Pages 877-883
Front Matter....Pages 885-885
gp130, common signal transducer for cytokines including IL-6....Pages 887-891
The Tyrosine Kinases pp561ck and pp59fyn are Activated in Thymocytes Undergoing Positive Selection....Pages 893-899
Back Matter....Pages 901-925