Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970

Front Matter....Pages I-IX
Complexes of Biologically Active Substances with Nucleic Acids — Yesterday, Today, Tomorrow....Pages 1-9
Kinetics of Binding of Drugs to DNA....Pages 10-20
The Binding of Actinomycin D to DNA....Pages 21-32
Interaction of Antitumor Antibiotics with DNA: Studies on Sibiromycin....Pages 33-39
Anthramycin....Pages 40-47
Inhibition of RNA Synthesis by Quinone Antibiotics....Pages 48-57
Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis....Pages 58-68
Chloroquine Binding to Nucleic Acids: Characteristics, Biological Consequences, and a Proposed Binding Model for the Interaction....Pages 69-90
A Preliminary Nuclear Magnetic Resonance Study of the Effect of pH on the Structure of Chloroquine Diphosphate....Pages 91-102
Effects of Chloroquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids....Pages 103-112
Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects on Various Enzymatic Reactions in Vitro....Pages 113-125
Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding....Pages 126-133
Interactions of Alkaloids with DNA....Pages 134-151
Physical Studies on the Interaction of Lysergic Acid Diethylamide and Trypanocidal Dyes with DNA and DNA-Containing Genetic Material....Pages 152-162
Comments on the Interaction of LSD with DNA....Pages 163-165
The Interaction of Polyamines with Nucleic Acids....Pages 166-180
The Use of Intercalative Dyes in the Study of Closed Circular DNA....Pages 181-215
Binding of Drugs to Supercoiled Circular DNA: Evidence for and against Intercalation....Pages 216-231
Mode of Action of Miracil D....Pages 232-246
Molecular Biological Effects of Nitroakridin 3582 and Related Compounds....Pages 247-261
Binding of Naphthylvinylpyridines to DNA....Pages 262-273
Formation of Yeast Mitochondria. V. Ethidium Bromide as a Probe for the Functions of Mitochondrial DNA....Pages 274-296
Studies on tRNA Structure Using Covalently and Noncovalently Bound Fluorescent Dyes....Pages 297-315
Antimutagens and Antimicrobial Drug Resistance....Pages 316-328
Some Studies on the Antimutagenic Action of Polyamines....Pages 329-346
Interaction and Linkage of Polycyclic Hydrocarbons to Nucleic Acids....Pages 347-370
Interaction of N-2-Acetylaminofluorene with RNA....Pages 371-381
Intercalability, the ψ Transition, and the State of DNA in Nature....Pages 382-391
Back Matter....Pages 393-400