Proceedings of the Ninth International Symposium on Cyclodextrins: Santiago de Compostela, Spain, May 31–June 3, 1998

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Development of a Fluorimetric-Fia Method to Monitor Cyclodextrin Production from Starch and the Formation of Inclusion Complexes....Pages 3-6
Development of Enzyme Immunoassays Specific for Natural ß- and γ-Cyclodextrins and Synthetic Derivatives. Pharmacokinetic Analysis of Cyclodextrins in Rat....Pages 7-10
The Role of Host - Guest Interaction in Thickening and Phase Separation of B-Cyclodextrin Polymer and Polymers Bearing Cyclic Hydrophobic Side Groups....Pages 11-14
Specific Binding and Precipitation of γ-Cyclodextrin with Monosaccharide in an Aqueous Solution....Pages 15-18
Analysis of Hydroxypropyl Cyclodextrins by Liquid Chromatography and Evaporative Light Scattering Detection....Pages 19-22
Lc-Elsd or (And) Lc-Ms: A Well Suited Technique For Characterization of the Differences in the Commercially Available Dm-ß-Cds....Pages 23-26
Thermal Degradation of Cyclodextrins....Pages 27-30
Front Matter....Pages 31-31
Selective Modifications of Cyclodextrins....Pages 33-36
Cyclodextrin Derivatives with Enhanced Solubilizing Power and Lower Toxicity....Pages 37-40
α-Cycloaltrin: Conformation and Properties in the Solid-State and Aqueous Solution [1] ....Pages 41-48
Symmetrical and Non-Symmetrical Urea Derivatives of ß-Cyclodextrin and Piperazine: Application in Capillary Electrophoresis....Pages 49-52
Sulfated Cyclodextrin Derivatives....Pages 53-56
The Molecular Geometries of Cyclofructins....Pages 57-62
Molecular Geometries of Furanoid ß(1→3)- and ß(1→6)-Linked Cyclogalactins....Pages 63-68
Synthesis and Characterization of Peptido-Cyclodextrins Dedicated to Drug Targeting....Pages 69-72
Mono-6-Tosyl-ß-Cyclodextrin: Preparation, Hydrolysis and Self-Inclusion Studies in Aqueous Solution....Pages 73-76
Thiourea-Bridged ß-Cyclodextrin Conjugates....Pages 77-80
Associations Of Amphiphilic Degradable Polymers With B-Cyclodextrin Polymers: Ph — Dependent Network....Pages 81-84
Original Associating System Between Hydrophobically Modified N,N-Dimethylacrylamide Hydroxyethylmetha-Crylate Copolymers and Water Soluble ß-Cyclodextrins Polymers....Pages 85-88
Production of Cyclomaltononaose (δ-Cyclodextrin) by Various Cyclodextrin Glycosyltransferases....Pages 89-92
Front Matter....Pages 31-31
Capillary Electrophoretic Investigation of the Inclusion Complex Forming Properties of Large Cyclodextrins....Pages 93-96
New Sorbents Containing ß-Cyclodextrin: Synthesis, Characterisation, and Sorption Properties....Pages 97-100
Preparation and Characterization of Sorbents Containing ßCd Derivatives Coated or Grafted onto Silica Gel....Pages 101-104
Comparative Cation Chelating Properties of Per (3,6-Anhydro),- And Per (3,6-Anhydro 2-Ome) α-Cyclodextrins....Pages 105-108
Synthesis of Cyclodextrin Glycerol Ethers and Investigation of their Binding Properties....Pages 109-112
Conformational Equilibria of a -Cycloaltrin in Solutions....Pages 113-115
The Synthesis of Oligosaccharide-Branched Cyclodextrins....Pages 117-120
Crystallization of Partially O-Alkylated ß -Cyclodex-Trins by Including Polymers....Pages 121-124
Synthesis of Per (2,3 -Di- O- Hexanoyl)- ß- Cyclodextrin and Characterization of Amphiphilic ß-Cyclodextrin Nanoparticles....Pages 125-128
Thiamine-Appended Cyclodextrin Dimer as a Ligase Model....Pages 129-132
Substituted Cyclodextrins with Amino Acids as Hydrolysis Enzyme Models....Pages 133-136
Synthesis and Molecular Recognition Abilities of Modified γ-Cyclodextrins Bearing Two Pyrene Moieties.....Pages 137-140
Molecular “Lego” Composed of Monosubstituted Cyclodextrins....Pages 141-144
Structural Analyses of Sugar Branched Cyclodextrin Derivatives by the Post-Source Decay Fragment Method in MALDI-TOF Mass Spectrometry....Pages 145-148
Three Dimensional Structure of Branched α-Cyclo-Dextrins in Solution....Pages 149-152
Synthesis and Enhanced Chemiluminescence of New Mono-Cyclomaltooligosaccharide-Bound 6-Phenylimidazo[1,2- a ]Pyrazin-3(7 H )-Ones....Pages 153-156
Thermal Behaviour and Phase Transitions of Cyclomaltononaose (δ-Cyclodextrin)....Pages 157-160
Textile Finishing with Mct-ß-Cyclodextrin....Pages 161-165
Isolation, Purification, and Characterization of Cyclomaltooctadecaose ( v -Cd) and Cyclomaltononadecaose (ξCd)....Pages 167-170
Supramolecular Assembly of Polycharged ß-Cyclodextrin Derivatives: Formation of Heterodimers Between A Polyamino- and a Polysulfonato-ß-Cyclodextrin....Pages 171-174
Front Matter....Pages 31-31
Insoluble Polymers with High Amounts of ßCD: Characterization and Adsorption Capacity....Pages 175-178
Influence of pH on the Stability of the Inclusion Complex of Methyl Orange and ß-Cyclodextrin....Pages 179-182
An Improved Synthesis of Per(6-Deoxyhalo) Cyclodextrins Using N -Halosuccinimides — Triphenylphosphine in Dimethylformamide....Pages 183-186
Front Matter....Pages 187-187
Anti-Asthmatic-Cyclodextrin Inclusion Complex for Pulmonary Delivery....Pages 189-192
Cyclodextrin-Containing Membranes. Synthesis and Separation Properties in Pertraction....Pages 193-196
Efficacy and Safety of Cyclodextrins in Nasal Drug Delivery....Pages 197-202
A Preliminary Study of a ß-Cyclodextrin/Salbutamol Complex for Possible Use in a Dry Powder Inhaler....Pages 203-206
Solubility of a Isoxazolyl-Naphthoquinone by Complexation with Hydroxypropyl-ß-Cyclodextrin....Pages 207-210
A Comparative Study of the Dissolution Properties of Piroxicam-ß-Cyclodextrin Inclusion Complexes Prepared by Different Methods....Pages 211-214
A Comparative Pharmacokinetic Study of Intravenous Solutions of Miconazole with or without Cyclodextrins.....Pages 215-218
Development of a Sustained Release Dosage form Containing a Diclofenac-Cyclodextrin Inclusion Complex.....Pages 219-222
Influence of Cyclodextrins on the Solubility and the Pharmacokinetics of Albendazole....Pages 223-226
Evaluation of Spironolactone Bioavailability from Solutions of ß-Cyclodextrin Derivatives in Rats....Pages 227-230
Chemosensors of Modified Cyclodextrins for Detecting Molecules....Pages 231-234
Molecularly Imprinted Cyclodextrin Polymers as Artificial Receptors -The Requisites for Remarkable Imprinting....Pages 235-238
New Developments in Improvement of Drug Solubility and Availability by Cyclodextrins....Pages 239-246
Design and Evaluation of Colon-Specific Drug Delivery System Based on Cyclodextrin Conjugates....Pages 247-250
The Effect of 2-Hydroxypropyl-ß-Cyclodextrin on the Solubility, Stability and Brain Targeting of Chemical Delivery Systems for Neuropeptides....Pages 251-256
Enhanced Complexation Efficacy of Cyclodextrins....Pages 257-260
Coadministration of a Water-Soluble Polymer Increases the Usefulness of Cyclodextrins in Solid Oral Dosage Forms....Pages 261-264
Front Matter....Pages 187-187
Evaluation of Degradation Studies Performed in Aqueous Cyclodextrin Solutions....Pages 265-268
The Effect of Cellulose Ethers on Indomethacin/Cyclodextrin Complexation....Pages 269-272
Physico-Chemical Characterization and Pharmacological Properties of Different Cyclodextrin Complexes of a Platelet Activating Factor Receptor Antagonist: SR 27417A.....Pages 273-276
Mutual Solubility Enhancement by Binary and Multicomponent Complexation of Clomiphene and Tamoxifen....Pages 277-280
Preparation and Characterization of Piroxicam Alkali-Salt γ-Cyclodextrin Complexes....Pages 281-284
Design and Evaluation of a Porosity-Controlled Osmotic Pump Tablet for Chlorpromazine Using (Sbe)7m-ß-CD....Pages 285-288
Comparison of the Solubilizing Effect of Ethyl Carbonate of γ-Cyclodextrin to Other Cyclodextrin Derivatives....Pages 289-292
Improved Solubility and Oral Bioavailability of Cyclosporin a by Hydrophilic Cyclodextrin Complexation....Pages 293-296
Effect of Amorphous ß-Cyclodextrins on Crystallization and Polymorphic Transition of Tolbutamide in Solid State....Pages 297-300
A New Method for Determination of Stability Constant of Cyclodextrin Complexes by Membrane Permeation Technique....Pages 301-304
Effects of Hydrophilic Cyclodextrins on Aggregation of Recombinant Human Growth Hormone....Pages 305-308
Preparation and Pharmaceutical Evaluation of Heptakis(2,6-Di- o -Methyl-3- o -Acetyl)-ß-Cyclodextrin....Pages 309-312
Characterization of Itraconazole / 2-Hydroxypropyl-ß-Cyclodextrin Inclusion Complex in Aqueous Solution....Pages 313-316
Sustained Release and Intestinal Absorption of Drug from the Hydrophobic α-, ß- and γ-Cyclodextrin Complexes....Pages 317-320
Hydroxypropyl Gamma Cyclodextrin as a Solubiliser and Dissolution Enhancing Agent: The Case of Tolbutamide—A Poorly Water-Soluble Drug....Pages 321-324
Interactions of Surfactants with Tolbutamide-ß-Cyclodextrin Inclusion Compound: The Consequence in Drug Dissolution....Pages 325-328
Differential Scanning Calorimetry as an Analytical Tool in Determining the Interaction Between Drug and Cyclodextrin....Pages 329-332
Solubility Enhancer Decreases the Dissolution of Complexed Drugs: Effect of Sodium-Lauryl-Sulfate on Dissolution Profile of Complexed Drugs....Pages 333-336
Interaction Between Ranitidine Hydrochloride and ß-Cyclodextrin....Pages 337-340
Physical and Chemical Changes in the Properties of ß-Cyclodextrin on Inclusion Complex Formation....Pages 341-342
Front Matter....Pages 187-187
A New Non-Linear Method on Determination of the Stability Constant for Steroid-Cyclodextrin Complex....Pages 343-346
2,4-Dichlorophenoxyacetic Acid α- and ß-CD Inclusion Complexes. A 1 H-Nuclear Magnetic Resonance Study....Pages 347-350
Investigation of the Inclusion Complex and Stoichiometry of Omeprazole with ß-Cd By 1 H Nmr Spectroscopy....Pages 351-354
Influence of Cyclodextrins on the Chemical Stability of Salmon Calcitonin in Aqueous Solution....Pages 355-358
Complexation Properties of ß-Cyclodextrin Sulfobutylether Sodium Salt....Pages 359-362
How Do Cyclodextrins Enhance Drug Permeability through Biological Membranes?....Pages 363-366
Differential Scanning Calorimetry Analysis of Crystallinity Changes of Naproxen in Ground Mixtures with Maltohexaose, the Non Cyclic Analog of Alpha-Cyclodextrin....Pages 367-370
Dissolution Rate and Thermal Properties of Naproxen in Mixtures with Amorphous or Crystalline Dimethyl Beta-Cyclodextrin....Pages 371-374
Improvement of Econazole Solubility in Multicomponent Systems with Cyclodextrins and Acids....Pages 375-378
Phase-Solubility Analysis and Molecular Modeling in the Study of Naproxen-Cyclodextrin Interaction....Pages 379-382
Potency Modification of Antibacterial Adamantane Derivatives by Compexation with ßCD and HP-ßCD. Study of their Thermotropic Properties in Dipalmitoyl Phosphatidylcholine Bilayers Containing Cholesterol and 13 C NMR Study of Their Structures....Pages 383-386
Pharmacological Investigations of New Peptido-Cyclodextrins....Pages 387-390
Characterization of Cyclodextrin Complexes of (S)-Naproxen by X-Ray and Thermal Methods of Analysis....Pages 391-394
CD-Medium Control of Microbial Sterol Sidechain Cleavage....Pages 395-398
Compressional Properties of Cyclodextrins....Pages 399-402
 In Vitro and in Vivo Investigations of the Specific Binding of Substance P-γ-Cyclodextrin Adducts to Rat Brain Nk1 Receptors....Pages 403-406
Stabilization of Retinol with γ-Cyclodextrin....Pages 407-410
Inclusion Study in ß-Cyclodextrin and Dimetyl-ß-Cyclodextrin of Antiparasitaries in Solution and the Solid State....Pages 411-414
Study of Inclusion Compound of Triamcinolone Acetonide....Pages 415-418
Complexation of Bile Salts by ß-Cyclodextrin and Derivatives....Pages 419-422
Front Matter....Pages 187-187
HNMR Contribution to Prove the Formation of Inclusion Complex Between Nimesulide and ß-Cyclodextrin and its Hydrophilic Derivatives....Pages 423-426
Complexation of Amino Acids by 6 A -(Hydroxyethylamino)-6 A -Deoxy-ß-Cyclodextrin (ß-CDEA) and the Metallo-Derivatives in Aqueous Solution....Pages 427-431
Effect of the Complexation of Ciprofloxacin and Norfloxacin with Cyclodextrin Derivatives on its Dissolution Characteristics....Pages 433-436
Effect of Hydroxypropyl- ß- Cyclodextrin on the Stability of Pilocarpine in Solution. Influence of the Complex Preparation....Pages 437-440
Dissolution Behavior of Diclofenac Sodium- ß- and Hydroxypropyl-ß-Cyclodextrin Inclusion Complexes....Pages 441-444
Effect of (SBE) 7M -ß-CD on Methylprednisolone Transport across Ethylcellulose Microporous Membranes....Pages 445-448
Optimization of Entrapment of Metronidazole in Amphiphilic ß-Cyclodextrin Nanospheres....Pages 449-452
Cyclodextrin Polysulfates in Cell Biology and Therapeutic Pharmacology....Pages 453-458
The Use of (SBE) 7M -ß-CD (Captisol™) as a Solubilizing and Osmotic Agent for Controlled and Complete Oral Delivery of Poorly Water Soluble Drugs....Pages 459-462
Preparation and Characterization of Inclusion Complexes of Cyclodextrins and Tuberculosis Primary Treatment Drugs....Pages 463-466
Influence of Different Cyclodextrins on Physico-Chemical and Pharmacological Properties of Etodolac....Pages 467-470
Solid-State Nifedipine-Cyclodextrin Photostability Studies....Pages 471-474
Inclusion Complexation of Nimesulide with ß-Cyclodextrins and its Formulation into Tablets....Pages 475-478
Inclusion Complexation of Tolfenamic Acid with ß-Cyclodextrins and its Formulation into Tablets....Pages 479-482
Preparation by Extrusion/Spheronization of Triamcinolone / ß-Cyclodextrin Pellets as a Fast Release Dosage Form....Pages 483-486
Front Matter....Pages 487-487
Renaturation of SDS- and Thermally Denatured Cellulase System by α-Cyclodextrin....Pages 489-492
Absorption and Recovery of Volatile Chlorinated Hydrocarbons by Use of Aqueous Solutions of Branched Cyclodextrins....Pages 493-496
Oxidation of Hydrophobic O -Diphenols by Lipoxygenase in the Presence of Cyclodextrins....Pages 497-500
Inclusion Properties, Metal Ion Coordination Ability and Analytical Applications of Trehalose Capped Cyclodextrins....Pages 501-504
Covalent and Non-Covalent Adducts Based on Cyclodextrins and Poly(Ethyleneoxide)....Pages 505-508
Front Matter....Pages 487-487
The Effect of Cyclodextrins on the Hydrolysis of Benzyl Halides....Pages 509-512
Regioselective Substitution of Cyclodextrins without Using Protecting Groups....Pages 513-516
Molecular Imprinting System Using Cyclodextrin....Pages 517-520
Energy Transfer in Naphthalene-Containing Rotaxane and Polyrotaxane....Pages 521-524
Kinetic Study of the Oxidation of Linoleic Acid by Lipoxygenase in Presence of β-Cyclodextrin....Pages 525-528
Esterolysis Reaction Catalysed by Beta-Cyclodextrin: Influence of the Tacticity of Water-Soluble Polymers.....Pages 529-532
Cyclodextrin Assistance in the Enzymatic Degradation of the moringa Glucosinolate....Pages 533-536
Kinetic Effects on the Dismutation of Superoxide Radical by Copper(II) Complexes of Cyclodextrin-Based Sod Models....Pages 537-540
Cyclodextrins as Molecular Templates....Pages 541-543
Cyclodextrin Radicals Produced by Photochemical Hydrogen Abstraction by Ketones and Nitrogen Heterocycles....Pages 545-548
Oxidative Stability of Docosahexaenoic Acid Oil (Triglyceride Form) Included in Cyclodextrins....Pages 549-552
Molecular Recognition of a Self-Assembled Monolayer of a Polydithiocarbamate Derivative of β-Cyclodextrin on Silver....Pages 553-556
Inhibition by Cyclodextrins of Nitrosation Reactions....Pages 557-561
Molecular Necklaces Containing Reporter Molecules....Pages 563-566
Molecular Dynamics Simulations of Polyrotaxanes Formed by Poly(Oxytrimethylene) and α-Cyclodextrins....Pages 567-570
Kinetic Behavior of β-Cyclodextrins Immobilized in PEEK-WC Membranes....Pages 571-573
Front Matter....Pages 575-575
Application of Cyclodextrins in Nuclear Waste Management....Pages 577-582
Optimization of Fuel Oil Desulfuration by β-Cyclodextrin....Pages 583-586
Inclusion of Environmental Contaminants with β-Cyclodextrin, and Adsorption and Removal by β-Cyclodextrin Polymer....Pages 587-590
Luminescent Behavior of Eu(nta) 3 dipy Complex in the Presence of β-Cyclodextrins....Pages 591-594
Front Matter....Pages 575-575
Study of Complexation Between the Pesticide Chlorpyrifos and β and Hp-β Cyclodextrins....Pages 595-598
Application of Randomly Methylated β-Cyclodextrin for Bioremediation of Contaminated Soil....Pages 599-602
Front Matter....Pages 603-603
Modified Cyclodextrins as Versatile Chiral Stationary Phases in Flavour Chemistry and Life Sciences....Pages 605-608
β-Cyclodextrins as Molecular Scaffolds to Reverse the Regioselectivity of Nitrile Oxide Cycloadditions....Pages 609-612
Analysis and Characterisation of Commercial DM-β-CD. Influence of Mixture Composition on Chiral Separation in Capillary Electrophoresis and Supercritical Fluid Chromatography....Pages 613-616
Pure Monopentenylated β-Cyclodextrin as Chiral Agent: Purity Check by LC-ELSD and LC-MS....Pages 617-620
Cyclodextrins Dominate the Chiral Chromatography....Pages 621-624
New Asymmetric β-Cyclodextrin Derivatives Designed for Chiral Recognition....Pages 625-628
Front Matter....Pages 629-629
Study of the Formation of the Inclusion Compound Between Rhodium(II) 3-Chlorocinnamate and β-Cyclodextrin.....Pages 631-634
Formation of Inclusion Complex of Cyclodextrin in Organic Solvents and Alcohols under Anhydrous Conditions....Pages 635-638
Inclusion Complexes of UV Filters in Solution and in Solid State....Pages 639-643
Encapsulation of Porphyrins by γ-Cyclodextrin....Pages 645-648
Guest-Dependent Ordering of the Self-Assembled Cyclodextrin Inclusion Complexes Studied by Scanning Tunneling Microscopy....Pages 649-652
The Application of Differential Conductivity Method to the Determination of Binding Constant of β-Cyclodextrin with Sodium Perfluorooctanoate....Pages 653-656
Influence of the Guest, the Type and Degree of Substitution on Inclusion Complex Formation of Substituted β-Cyclodextrins....Pages 657-658
Reliable NMR Experiments for the Determination of the Structure of Cyclodextrin Inclusion Complexes in Solution....Pages 659-662
 1 H NMR, Circular Dichroism and Uv-Visible Spectroscopic Study of Inclusion Complexes Formation Between o-, m-, p- Hydroxyphenol and β-Cyclodextrin....Pages 663-666
Molar Partial Properties in Host-Guest Systems: Application to the Inclusion Complexes between β- Cyclodextrin and Sodium Alkanoates....Pages 667-670
The Binding of 2-Naphthamides to β-Cyclodextrin....Pages 671-674
Publications — New Products; Is there any Correlation?....Pages 675-678
Front Matter....Pages 679-679
Preliminary Study of Dye Sorption by Various Kinds of Insoluble Sorbents Containing beta- Cyclodextrin....Pages 681-684
Release Characteristics of Hydrophobic Flavor Encapsulated in Cyclodextrins....Pages 685-688
A 1 H-NMR Study of Inclusion Compounds of Model Food Flavours in β-Cyclodextrin....Pages 689-692
β-Cyclodextrin Emulsion: Mecanism of Emulsification and Application to the Preparation of Green Metalworking Fluids....Pages 693-696
Back Matter....Pages 697-707