Proceedings of the Fourth International Symposium on Cyclodextrins : Munich, West Germany, April 20-22, 1988

Front Matter....Pages i-xi
Introductory Remarks....Pages 1-3
Front Matter....Pages 5-5
Enzymology and Molecular Genetics of CD-Forming Enzymes....Pages 7-17
Studies on the Reaction Mechanism of Cyclodextrin Glycosyltransferases: Subsite Analysis....Pages 19-26
Cultural Characteristics of an Cyclomaltodextrin Glucano-Transferase-Producing Alkalophilic Bacillus Sp.....Pages 27-31
Use of Cyclohexane in the Production of Pure alpha - and b eta -Cyclodextrins....Pages 33-39
Cyclodextrins from Potato Starch. Recent Developments.....Pages 41-46
Production of Cyclodextrins Using Immobilized Enzymes....Pages 47-53
Immobilization of Pullulanase and Successive Synthesis of Branched Cyclodextrins by Immobilized Pullulanase....Pages 55-59
The Acid Hydrolysis of Cyclodextrins and Linear Oligosaccharies: a comparative study....Pages 61-63
Isolation and Purification of Gamma-Cyclodextrin by Affinity Chromatography....Pages 65-70
Cloning and Nucleotide Sequence of a Cyclodextrin Glycosyltransferase Gene from the Alkalophilic Bacillus 1-1....Pages 71-76
Expression of the Gene for Cyclodextrin-Glycosyl-Transferase from Klebsiella in E. Coli ....Pages 77-80
Method Development for Economic Production of Cyclodextrins by Means of Ternary Complex Formation....Pages 81-86
Selective Complexing Agents for the Production of γ-Cyclodextrin....Pages 87-92
Front Matter....Pages 93-93
Preparation and N.M.R. Study of Maltooligomers....Pages 95-101
A Chemically Modified Cyclodextrin....Pages 103-111
Methylation of Cyclodextrins Via Phase-Transfer Catalysis....Pages 113-117
Environmental Effects on Molecular Properties of Organic Compounds. Part III. Cyclodextrins with a Schiff Base Moiety....Pages 119-123
The Inclusion Properties of 6-Linked β-Cyclodextrin 1-Thio-β-D-Glycosides....Pages 125-128
Selective Multiple 6-Substitution in Cyclodextrin by Hydrophobic and Hydrophilic Groups....Pages 129-132
Front Matter....Pages 93-93
Inclusion Properties of Hydrophobic Derivatives of Cyclodextrins (CDs)....Pages 133-138
Cyclodextrin — Cellulose Copolymers....Pages 139-143
Characterization of Cyclodextrin Derivatives by the Reductive-Cleavage Method....Pages 145-149
Modified Cyclodextrins; Substitution at O3 and Complexation of Metals....Pages 151-155
Front Matter....Pages 157-157
Chemical and Physical Studies on Cyclodextrin Inclusion Compounds....Pages 159-164
Preparation and 13 C NMR Identification of Solid Cyclodextrin Inclusion Compounds....Pages 165-171
Inclusion Compounds in Water. Interaction of α-Cyclodextrin with UREA Derivatives at 25°C....Pages 173-179
Dynamic Aspects of Molecular Inclusion Reactions by Cyclodextrins....Pages 181-187
Interaction of Cyclodextrins with Glycolipids. 1 H-NMR Studies....Pages 189-195
Chemically-Modified Cyclodextrins as Second Sphere Ligands for Transition Metal Complexes....Pages 197-203
Some Interesting Aspects in 1 H-NMR Spectroscopy by Cyclodextrin Complexation....Pages 205-208
Molecular Inclusion Reaction of Charged Cyclodextrins....Pages 209-213
Inclusion Complexes of Naphthols with Cyclodextrins in Aqueous Solution. A 1 H-NMR Study....Pages 215-219
IR-Spectroscopic Measurement of the p-Nitrophenol - β-Cyclodextrin Equilibrium in Aqueous Solution....Pages 221-225
Complexes of Insoluble Cyclodextrin Polymers....Pages 227-235
Methods for Characterization of the Wettability of Cyclodextrin Complexes....Pages 237-241
Detailed Structure of an α Cyclodextrin-Cyclopentanone Clathrate by Neutron Diffraction....Pages 243-246
Influence of Ethanol on the Complexation of Isomeric Chloronitrobenzenes by β -Cyclodextrin....Pages 247-252
Charaterisation of β-Cyclodextrin Complexes....Pages 253-261
Front Matter....Pages 263-263
New Trends in Pharmaceutical Applications of Cyclodextrin Inclusion Compounds....Pages 265-275
Front Matter....Pages 263-263
Menadione Inclusion Compounds with Mixtures of Natural Cyclodextrins....Pages 277-283
Interactions between Cyclodextrins and Some Antimycotic Imidazole Derivatives: Studies on Solubility and Antimicrobial Activity....Pages 285-291
Increasing the Solubility Characteristics of Iomeglamic Acid with β -Cyclodextrin....Pages 293-298
The Inclusion Complex of Tolbutamide with Maltosyl(G 2 )- β-Cyclodextrin in Aqueous Solution and in the Solid State....Pages 299-306
Complexation of Polyene Antibiotics with γ-Cyclodextrin....Pages 307-312
The Effect of Cyclodextrins on the Mitomycin Stability in Acidic Aqueous Media....Pages 313-317
Assessment of the Stoichiometry of a Vinburnine and Gammacyclodextrin Complex by Microcalorimetry....Pages 319-323
Molecular Encapsulation of Retinoic Acid by β -Cyclodextrin, Characterization of the Inclusion Compound....Pages 325-328
Solubility Enhancement of Ipriflavone by Cyclodextrin Complexation....Pages 329-335
The Effect of Beta-Cyclodextrin Complexation on Plasma Levels of Ipriflavone and its Main Metabolites....Pages 337-341
The Comparison of Absorption, Distribution and Elimination of Ipriplavone-14C and Ipriplavone-14C-Beta-Cyclodextrin Inclusion Complex....Pages 343-347
The Influence of Inclusion by Cyclodextrins on Absorption Kinetics of Dantrolene in the Rat....Pages 349-353
Improvement on Photostability of Several Essential Oils and Menadione by Natural Cyclodextrins....Pages 355-358
Bitterness Reduction with Beta-Cyclodextrin....Pages 359-366
Front Matter....Pages 367-367
Cyclodextrin Derivatives for Solubilisation, Stabilisation, and Absorption of Drugs....Pages 369-382
Biomedical Uses of Amorphous Water Soluble Derivatives of Cyclodextrins....Pages 383-391
Highly Soluble ß-Cyclqdextrin Derivatives, a Comparative Study....Pages 393-398
Water Soluble Complexes of a Brain-Targeted Drug Delivery System....Pages 399-405
Pharmacokinetics of Dimethyl-Beta-Cyclodextrin in Rats....Pages 407-413
Percutaneous Absorption of Heptakis-(2,6-Di-O- 14 C-Methyl)-β -Cyclodextrin in Rats....Pages 415-420
Front Matter....Pages 367-367
Investigation of the Hemolytic Effect of the Cyclodextrin Derivatives....Pages 421-425
Determination of Hydroxypropyl-β-Cyclodextrin in Plasma and Urin by Size Exclusion Chromatography with Post Column Complexation....Pages 427-433
Front Matter....Pages 435-435
Cyclodextrins in Analytical Chemistry....Pages 437-449
Cyclodextrins in Chromatography and Isotachophoresis....Pages 451-463
Enantioselective Capillary Gas Chromatography with Modified Cyclodextrins as Chiral Stationary Phases....Pages 465-471
HPLC of Chloramphen Icol and Some of its Synthetic Intermediates on a Cyclo Dextrin-BonDed Chiral Stationary Phase....Pages 473-477
GC Capillary Columns with Cyclodextrins as Stationary Phases....Pages 479-483
Fluorescence Studies of Cyclodextrin Complexes....Pages 485-491
Immobilized Cyclodextrins for Affinity Chromatography....Pages 493-496
Gelchromatographic Separation of Proteins on Cyclodextrin Bead Polymers....Pages 497-501
 β -Cyclodextrin in Optical Resolution of Chiral Sulphinyl Derivatives....Pages 503-507
Catalytic Activity of Artificial Hydrolases Using Modified Cyclodextrins....Pages 509-512
Functionalized Cyclodextrins as Oxydo-Reductasic Enzyme Models....Pages 513-517
Selective Reductions of CD Complexed Terpenes....Pages 519-523
Reactions in the Presence of Cyclodextrins....Pages 525-530
Front Matter....Pages 531-531
Application of Cyclodextrins to Foods, Toiletries and Other Products in Japan....Pages 533-543
Long Term Storage Stability Studies on Flavour- β -Cyclodextrin Complexes....Pages 545-549
Application o Beta Cyclodextrin in Meat Industry....Pages 551-555
Effect of Cyclodextrin and Glycerolmonostearate on Starch Gelatinization....Pages 557-560
Fungicidal Activity of Benomyl in Presence of β-Cyclqdextrin....Pages 561-567
Back Matter....Pages 569-576