Proceedings / Eighth International Mining Geology Conference 2011, 22-24 August 2011, Queenstown, New Zealand

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Stable isotopes: essential tools in biological and medical research....Pages 3-14
Mass spectrometric methods of isotope determination....Pages 15-26
Stable isotopes in human drug metabolism studies....Pages 27-42
Front Matter....Pages 43-43
Applications of deuterium labelling in pharmacokinetic and concentration-effect studies of clonidine....Pages 45-54
Isotope effects on pathways of metabolism....Pages 55-64
Use of stable-isotope-labelled compounds in pharmaceutical research....Pages 65-84
The use of deuterium labelling in mechanistic studies of metabolic activation....Pages 85-95
The quantitation by gas chromatography-chemical ionisation-mass spectrometry of cyclophosphamide, phosphoramide mustard and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy....Pages 97-106
Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards....Pages 107-112
Drug metabolism and pharmacokinetic studies in man utilising nitrogen-15- and deuterium-labelled drugs: the metabolic fate of cinoxacin and the metabolism and pharmacokinetics of propoxyphene....Pages 113-125
Bioavailability using cold labels: studies on a novel antidiarrhoeal agent SC-27166....Pages 127-138
The use of stable isotopes to better define toxic metabolic pathways of p-hydroxyacetanilide (acetaminophen) and p-ethoxyacetanilide (phenacetin)....Pages 139-147
A new method for the investigation of inter-individual differences in drug metabolism....Pages 149-155
Discrimination between endogenous and exogenous testosterone in human plasma after oral treatment with testosterone undecanoate using stable-isotope-labelled compounds and mass spectrometric analyses....Pages 157-165
Front Matter....Pages 167-167
Application and potential of coenzyme labelling....Pages 169-175
Pathways of steroid metabolism in vivo studied by deuterium labeling techniques....Pages 177-188
Characterisation of bile acid metabolism in man using bile acids labelled with stable isotopes....Pages 189-204
Detection and quantification of stable isotope incorporation by high-resolution mass spectrometry and 13C{2H,1H} nuclear magnetic resonance difference spectroscopy. Utilisation of carbon and hydrogen atoms of ethanol in the biosynthesis of bile acids....Pages 205-216
Teratological studies on effects of carbon-13 incorporation into preimplantation mouse embryos on development after implantation in vivo and in vitro....Pages 217-225
13CO2 breath tests in normal and diabetic children following ingestion of 13C-glucose....Pages 227-234
Front Matter....Pages 167-167
Studies on catecholamine metabolism in man using in vivo deuterium labelling....Pages 235-245
The metabolism of deuterium-labelled p-tyramine in man....Pages 247-252
Studies in man using semi-tracer doses of deuterated phenylalanine and tyrosine: implications for the investigation of phenylketonuria using the deuterated phenylalanine load test....Pages 253-260
Application of chemical ionization mass spectrometry and stable isotopes in studies of α-methyldopa metabolism....Pages 261-279
The role of prostaglandins in the pathogenesis of human disease: elucidation with stable isotopic methods....Pages 281-287
Application of deuterium labelling in studies of the biosynthesis and metabolism of prostaglandin F2α in man....Pages 289-301
Balance of water, urea and creatinine in peritoneal dialysis....Pages 303-309
Back Matter....Pages 311-314