Prediabetes

Front Matter....Pages i-xii
Front Matter....Pages 1-1
History: The Discovery of Prediabetes in Animals....Pages 3-5
Hereditary Diabetes in the KK Mouse: An Overview....Pages 7-15
Development of Microvascular and Islet Cell Alterations in Rats with Spontaneous Non Insulin-Dependent Diabetes....Pages 17-27
Development of Diabetes in the Non-Obese NIDDM Rat (GK Rat)....Pages 29-31
Spontaneous Diabetes in Macaca Nigra : Relevance to Human Beings with NIDDM....Pages 33-41
Front Matter....Pages 43-43
Insulin Autoantibodies in Pre-Diabetes....Pages 45-51
Sites of the Defects Leading to Autoimmunity in the Spontaneously Diabetic BB Rat....Pages 53-62
Assay for Cytoplasmic Islet Cell Antibodies Using Two-Color Immunofluorescence and Rat Pancreas....Pages 63-69
Cytoplasmic Islet Cell Autoantibodies: Prevalence and Pathognomic Significance....Pages 71-77
A New Marker of T Lymphocyte Activation in Type I Diabetes....Pages 79-84
Front Matter....Pages 85-85
Studies of Prediabetes in the Spontaneously Diabetic BB Rat....Pages 87-91
Chemically-Initiated Hyperglycemia: Streptozotocin-Specific T Lymphocyte Reactions....Pages 93-100
Diabetic Lymphocytes Transfer and Beta Cell Functions....Pages 101-107
Lymphocyte Subsets in Pre-Diabetes....Pages 109-118
The in Vivo Visualization of Insulitis a New Marker of Prediabetes....Pages 119-125
Genetic Relationships Between Type I and Type II Diabetes Mellitus....Pages 127-132
Front Matter....Pages 133-133
Kidney Disease in KK Mice: Structural, Biochemical and Functional Relationships....Pages 135-145
Sequence of Changes in KK Mouse Nephropathy....Pages 147-158
Abnormal Response to Glucose in the Prehyperglycemic Stage....Pages 159-165
Low Insulin Response: A Marker Of Prediabetes....Pages 167-174
Front Matter....Pages 133-133
Study of Glucose Removal Rate and First Phase Insulin Secretion in the Offspring of Two Parents with Non-Insulin-Dependent Diabetes....Pages 175-183
Antecedent Events for Non-Insulin Dependent Diabetes Mellitus....Pages 185-192
Hemostasis and Endothelial Disorders in Pre-Diabetes....Pages 193-195
Microchannels in Prediabetes....Pages 197-205
Front Matter....Pages 207-207
Iselt-Cell and Insulin Autoantibodies in First-Degree Relatives of Type I Diabetics: A 5-Year Follow-Up Study in a Swiss Population....Pages 209-214
Childhood Insulin-Dependent Diabetes....Pages 215-219
Children at High Risk of Diabetes Mellitus: New York Studies of Families with Diabetes and of Children with Congenital Rubella Syndrome....Pages 221-227
Family Studies of Insulin-Dependent Diabetes: The UK Experience....Pages 229-233
Can the High Risk of Type I Diabetes in Finland be Explained by Familial Aggregation and by HLA Haplotype Distribution?....Pages 235-239
Genetic and Humoral Markers in IDDM Patients and their Families....Pages 241-253
Development of Diabetes in Identical Twins....Pages 255-258
Type-Specific Concordance in Young Diabetic Monozygotic Twins....Pages 259-267
Prediabetes and the Pathological Lesions of the Pancreas....Pages 269-274
Front Matter....Pages 275-275
Diabetogenicity of Various Protein Sources in the Diet of the Diabetes-Prone BB Rat....Pages 277-285
Effect of Alpha-Inhibitors on Blood Glucose and Insulin Levels....Pages 287-295
Kidney Disease in KK Mice: Effect of Glyburide....Pages 297-303
Kidney Disease in KK Mice: Effect of Glipizide....Pages 305-312
Effect of Gliclazide on Non-Insulin Dependent Diabetes Mellitus....Pages 313-319
Plasma Activity of the Enzyme N-Acetil-Beta-Glucosaminidase in Healthy and Diabetic Subjects: Effects of Treatment with A Sulfonylurea Drug....Pages 321-327
Continuous Insulin Treatment in the Chinese Hamster a Review....Pages 329-332
Front Matter....Pages 275-275
Kidney Disease in KK Mice: Effect Of Insulin....Pages 333-337
Some Characteristics of Chemically-Induced Beta-Cell Lesions as Possible Contributing Factors in Diabetes....Pages 339-346
Effects of Immunosuppression with Cyclosporine on Beta Cell Function and Clinical Remission in Very Early Overt Type I Diabetes....Pages 347-355
Immunomodulation of Pre-Diabetes in BB Rats for Prevention of the Disease....Pages 357-364
Prevention of Diabetes-Related Retinal Microangiopathy with Aldose Reductase Inhibitors....Pages 365-376
Front Matter....Pages 377-377
Regulatory T Cell Control of Autoimmune Destruction of Beta Cells In The BB Rat....Pages 379-385
Prevention of Diabetes in the BB Rat by Injection of Major Histocompatibility Complex- (MHC-) Compatible Bone Marrow Cells....Pages 387-395
The Incidence of Diabetes in BB Rats is Decreased Following Acute LCMV Infection....Pages 397-402
Strategies for Primary Prevention of Non-Insulin Dependent Diabetes Mellitus....Pages 403-413
Back Matter....Pages 415-421