Porphyrins in Tumor Phototherapy

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Excited State Properties of Haematoporphyrin....Pages 3-10
Fluorescence Properties of HpD and its Components....Pages 11-21
The Structure of the Active Component of Hematoporphyrin Derivative....Pages 23-35
Photophysical and Photosensitizing Properties of Photofrin II....Pages 37-43
On the Purification of Hematoporphyrin IX and its Acetylated Derivatives....Pages 45-49
Photosensitizing Properties of Porphyrins in Model Cell Systems....Pages 51-60
Photosensitizing Properties of Free and Bound Uroporphyrin I....Pages 61-65
Chemical and Biological Studies on Haematoporphyrin Derivative: An Unexpected Photosensitisation in Brain....Pages 67-80
A Chromatographic Study of Hematoporphyrin Derivatives....Pages 81-91
Protection by Carotenoids from Singlet Oxygen Photoproduced by Porphyrins....Pages 93-94
Effect of He-Ne Laser on Human Erythrocytes Incubated with Hematoporphyrin Derivative and Bonellin: Comparative Study....Pages 95-99
Survey of Potential PRT Dyes and their Spectroscopic Properties....Pages 101-105
Front Matter....Pages 107-107
Fluorescence of Porphyrins in Cells....Pages 109-124
Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells....Pages 125-136
Time-Resolved Laser Fluorescence and Photobleaching of Single Cells after Photosensitization with Hematoporphyrin Derivative (HpD)....Pages 137-141
Effects of HpD and Laser on Transformed and Corresponding Normal Cultured Cells: Differential Cytotoxicity as an in Vitro Model for Tumor Photochemotherapy....Pages 143-155
Interaction of Free and Liposome-Bound Porphyrins with Normal and Malignant Cells: Biochemical and Photosensitization Studies in Vitro and in Vivo....Pages 157-165
Photodynamic Inactivation of L929 Cells after Treatment with Hematoporphyrin Derivative....Pages 167-175
Bacterial and Yeast Cells as Models for Studying Hematoporphyrin Photosensitization....Pages 177-183
Cholesterol Impregnation into Erythroleukemia Cell Membrane Induces Resistance to Hematoporphyrin Photodynamic Effect....Pages 185-191
Front Matter....Pages 107-107
Photodynamic Effect of the He-Ne Laser with HpD on the Ultrastructure of Rhabdomyosarcoma Cell....Pages 193-200
Front Matter....Pages 201-201
Hematoporphyrin Derivative Phototherapy in Experimental Oncology....Pages 203-212
Photoradiation Therapy (PRT) of Lewis Lung Carcinoma in B 6 D 2 Mice, Dosimetry Considerations....Pages 213-220
Study of Irradiation Parameters in HpD Phototherapy of MS-2 Tumor Model....Pages 221-225
Experimental ENU Induced Brain Tumors with HpD and Dye Laser Light....Pages 227-233
Studies with Hematoporphyrin Derivative in Transplantable Urothelial Tumors....Pages 235-241
Time Dependance of 3H Hematoporphyrin Derivative Distribution in the Digestive Tract in the Rat....Pages 243-245
Nd Yag Destruction of Tumor Sensitized or Non Sensitized by HPD....Pages 247-249
HpD Phototherapy on Spontaneous Tumors in Dog and Cat....Pages 251-258
Front Matter....Pages 259-259
Thermal and Optical Dosimetry for Photoradiation Therapy of Malignant Tumors....Pages 261-279
Photophysics and Dosimetry of Photoradiation Therapy....Pages 281-291
An Optimised Laser System for the Evaluation of HpD Therapy....Pages 293-299
A Multi-Led Source for Photoradiation Therapy....Pages 301-308
Side Radiation Optical Fibers for Medical Applications....Pages 309-319
Fluorescence of Hematoporphyrin-Derivative for Detection and Characterization of Tumors....Pages 321-337
In Vivo Fluorescence Excitation Spectra of Hematoporphyrin-Derivative (HpD)....Pages 339-345
In Vivo Observations of Porphyrins and of the Light Action....Pages 347-353
Monitoring of Hematoporphyrin Injected in Humans and Clinical Prospects of its Use in Gynecologic Oncology....Pages 355-361
Front Matter....Pages 363-363
Hematoporphyrin Derivative Photoradiation Therapy, in Theory and in Practice....Pages 365-374
Evaluation of Photoradiation Therapy (PRT) in 20 Cases of Cancers....Pages 375-380
Front Matter....Pages 363-363
Hematoporphyrin Phototherapy of Malignant Tumors....Pages 381-387
Hematoporphyrin-Derivative and Phototherapy in Extensive Basal-Cell Carcinoma of the Dorsal Skin....Pages 389-394
Hematoporphyrin Derivative Photoradiation Therapy of Endobronchial Lung Cancer....Pages 395-403
Photoradiation Therapy in Early Stage Cancer Cases of the Lung, Esophagus and Stomach....Pages 405-412
Experimental and Clinical Studies on HPD-Photoradiation Therapy for Upper Gastrointestinal Cancer....Pages 413-421
Endoscopic HpD-Laser Photoradiation Therapy (PRT) of Cancer....Pages 423-426
Dye-Laser-Photoradiation-Therapy of Bladder Cancer after Photosensitization with Hematoporphyrin Derivative (HpD)-Basis for an Integral Irradiation....Pages 427-438
Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma....Pages 439-446
Preclinical Examination of Ocular Photoradiation Therapy....Pages 447-454
Photoradiation for Choroidal Malignant Melanoma....Pages 455-461
Back Matter....Pages 463-466