Platelets in Thrombotic and Non-Thrombotic Disorders : Pathophysiology, Pharmacology and Therapeutics

Frontmatter......Page 1
Contents......Page 5
List of contributors......Page 9
Editors' preface......Page 21
PART I - PHYSIOLOGY......Page 23
1 - History of platelets......Page 25
2 - Production of platelets......Page 47
3 - Morphology and ultrastructure of platelets......Page 63
4 - Platelet heterogeneity: physiology and pathological consequences......Page 92
5 - Platelet membrane proteins as adhesion receptors......Page 102
6 - Dynamics of the platelet cytoskeleton......Page 115
7 - Platelet organelles......Page 126
8 - Platelet receptors for thrombin......Page 135
9 - Platelet receptors: ADP......Page 149
10 - Platelet receptors: prostanoids......Page 162
11 - Platelet receptors: collagen......Page 180
12 - Platelet receptors: von Willebrand factor......Page 201
13 - Platelet receptors: fibrinogen......Page 210
14 - Platelet signalling: GTP-binding proteins......Page 226
15 - Platelet phospholipases A2......Page 243
16 - Roles of phospholipase C and phospholipase D in receptor-mediated platelet activation......Page 260
17 - Platelet signalling: calcium......Page 282
18 - Platelet signalling: protein kinase C......Page 294
19 - Platelet signalling: tyrosine kinases......Page 303
20 - Platelet signalling: cAMP and cGMP......Page 312
21 - Platelet adhesion......Page 326
22 - The platelet shape change......Page 341
23 - Aggregation......Page 360
24 - Amplification loops: release reaction......Page 379
25 - Amplification loops: thromboxane generation......Page 391
26 - Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system......Page 403
27 - Platelets and chemotaxis......Page 415
28 - Plateletâ•fileukocyte interactions relevant to vascular damage and thrombosis......Page 434
29 - Vascular control of platelet function......Page 454
PART II - METHODOLOGY......Page 479
30 - In vitro assays for evaluating platelet function......Page 481
31 - Monitoring antiplatelet therapy......Page 493
32 - Flow cytometric analysis of platelet function......Page 507
33 - Animal models of platelet-dependent thrombosis......Page 521
PART III - PATHOLOGY......Page 535
34 - Hereditary thrombocytopenias......Page 537
35 - Thrombocytopenias due to bone marrow disorders......Page 550
36 - Immune-mediated thrombocytopenia......Page 564
37 - Thrombocytopenia in childhood......Page 578
38 - Alloimmune thrombocytopenia......Page 591
39 - Drug-induced and drug-dependent immune thrombocytopenias......Page 606
40 - Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome......Page 632
41 - Thrombocytosis and thrombocythemia......Page 645
42 - Platelet adhesive protein defect disorders......Page 661
43 - Congenital disorders of platelet secretion......Page 677
44 - Congenital platelet signal transduction defects......Page 696
45 - Acquired platelet function defects......Page 711
46 - Platelet storage and transfusion......Page 729
47 - Pathophysiology of arterial thrombosis......Page 747
48 - Platelets and atherosclerosis......Page 760
49 - Platelet involvement in venous thrombosis and pulmonary embolism......Page 775
50 - Gene regulation of platelet function......Page 782
51 - Platelets and bacterial infections......Page 803
52 - Interactions of viruses and platelets and the inactivation of viruses in platelet concentrates prepared for transfusion......Page 829
53 - Platelets and parasites......Page 837
54 - Platelets and tumours......Page 846
55 - Platelets and renal diseases......Page 859
56 - Platelets and allergic diseases......Page 874
57 - Platelet interactions with other cells related to inflammatory diseases......Page 891
58 - Platelets and the preimplantation stage of embryo development......Page 907
59 - Platelets in psychiatric and neurological disorders......Page 916
60 - Platelets in inflammatory bowel disease......Page 929
PART IV - PHARMOLOGY......Page 939
61 - Aspirin......Page 941
62 - Pharmacology of ticlopidine and clopidogrel......Page 951
63 - Platelet membrane glycoprotein (GP) IIbâ•fiIIIa antagonists and acute arterial thrombosis......Page 962
64 - Other antiplatelet agents......Page 977
65 - Pharmacogenetics as a new antiplatelet strategy......Page 986
66 - Cardiovascular gene therapy: implications for platelet vessel wall interactions......Page 1000
67 - Pharmacological modulation of the inflammatory actions of platelets......Page 1013
PART V - THERAPY......Page 1023
68 - Design of trials to evaluate antiplatelet agents......Page 1025
69 - Antiplatelet therapy in cardiology......Page 1035
70 - Antiplatelet therapies in neurology......Page 1060
71 - Antiplatelet treatment in peripheral vascular disease......Page 1075
Afterword: Platelets: a personal story......Page 1083
Index......Page 1093
Plate section......Page 1122