Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
A Brief History of Blood Platelets: A Personal View....Pages 3-9
Phylogeny of Blood Platelets....Pages 11-19
Platelet Morphology and Ultrastructure....Pages 21-37
Megakaryocyte Development and Platelet Production....Pages 39-53
Platelet Heterogeneity....Pages 55-67
Regulation of Platelet Adhesion Receptors....Pages 69-84
The Platelet Glycoprotein Ib-IX-V Complex....Pages 85-97
αIIbβ3 (GPIIb/IIIa) Structure and Function....Pages 99-112
GPVI....Pages 113-127
The Role of CLEC-2 in and Beyond the Vasculature....Pages 129-138
Anatomy of the Platelet Cytoskeleton....Pages 139-156
Platelet Proteomics and its Applications to Study Platelet-Related Disorders....Pages 157-170
The Platelet PARs....Pages 171-185
The P2 Receptors....Pages 187-202
Platelet Prostanoids and their receptors....Pages 203-211
Platelet Genomics....Pages 213-226
The Platelet Transcriptome: Coding RNAs....Pages 227-238
Noncoding RNAs in Platelet Biology....Pages 239-252
Implications of Platelet RNA to Vascular Health and Disease....Pages 253-261
GTPases....Pages 263-284
Front Matter....Pages 1-1
Platelet Signalling: Calcium....Pages 285-296
Platelet Signaling: Protein Phosphorylation....Pages 297-308
Platelet Adhesion....Pages 309-319
Platelet Shape Change....Pages 321-336
The Migration of Platelets and their Interaction with Other Migrating Cells....Pages 337-351
Platelet Secretion....Pages 353-366
A Systems Approach to the Platelet Signaling Network and the Hemostatic Response to Injury....Pages 367-378
Platelet-Derived Microparticles....Pages 379-392
Platelet Interactions with the Blood Vessel Wall....Pages 393-406
Platelet–Leukocyte Interactions....Pages 407-433
The Role of Platelets in Lymphangiogenesis and Neoangiogenesis....Pages 435-445
Platelets and Coagulation....Pages 447-462
Platelets and Fibrinolysis....Pages 463-487
Platelets and Immunity....Pages 489-512
Platelets in Neurological Disorders....Pages 513-530
The Role of Platelets During Development and Reproduction....Pages 531-539
Platelet-Derived Inhibitors of Platelet Activation....Pages 541-556
Front Matter....Pages 557-557
Platelet Function Tests....Pages 559-570
Platelet Counting and Measurement of Platelet Dimensions....Pages 571-587
Flow Cytometry....Pages 589-617
Front Matter....Pages 557-557
Platelet Aggregation....Pages 619-635
Platelet Secretion....Pages 637-649
Platelet Activation Under Conditions of Flow....Pages 651-662
In Vivo Imaging of Thrombosis and Hemostasis....Pages 663-669
Monitoring of Antiplatelet Therapy....Pages 671-679
Mouse Models of Thrombosis....Pages 681-698
Next-Generation Sequencing in the Study of Platelets....Pages 699-714
Front Matter....Pages 715-715
Approach to the Patient with Platelet-Related Bleeding....Pages 717-725
Inherited Thrombocytopenias....Pages 727-747
Immune Thrombocytopenia: Where Are We Now?....Pages 749-760
Fetal and Neonatal Alloimmune Thrombocytopenia....Pages 761-770
Drug-Induced Thrombocytopenia: Pathogenesis, Diagnosis and Management....Pages 771-787
Heparin-Induced Thrombocytopenia....Pages 789-811
Thrombocytopenia in Pregnancy....Pages 813-823
Thrombocytopenia in the Newborn....Pages 825-840
Thrombocytopenia in Patients with Solid Tumors or Hematologic Malignancies....Pages 841-850
Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome....Pages 851-871
Thrombocytosis and Essential Thrombocythaemia....Pages 873-886
Platelet Adhesive Protein Defect Disorders....Pages 887-905
Defects of Soluble Agonists....Pages 907-916
Front Matter....Pages 715-715
Defects of Platelet Granules and Secretion....Pages 917-922
Defects of Platelet Signal Transduction....Pages 923-936
Alterations of the Platelet Procoagulant or Fibrinolytic Functions....Pages 937-949
Acquired Disorders of Platelet Function....Pages 951-973
Front Matter....Pages 975-975
Platelets in Arterial Thrombosis....Pages 977-992
Platelets in Atherosclerosis....Pages 993-1013
Platelets in Acute Coronary Syndromes....Pages 1015-1028
Platelets in Acute Ischemic Stroke....Pages 1029-1041
Platelets in Deep Venous Thrombosis and Pulmonary Embolism....Pages 1043-1051
Gene Regulation of Platelet Function....Pages 1053-1067
Front Matter....Pages 1069-1069
Platelets and Bacterial Infections....Pages 1071-1084
Virus–Platelet Associations....Pages 1085-1102
Platelets in Malarial Infection: Protective or Pathological?....Pages 1103-1109
Platelets: “First Responders” in Cancer Progression and Metastasis....Pages 1111-1132
Platelets and Inflammatory Disorders of Connective Tissue....Pages 1133-1137
Platelets and Skin Disorders....Pages 1139-1147
Platelets and Airway Diseases....Pages 1149-1168
Hemostatic and Non-hemostatic Functions of Platelets in Patients with Liver Disease....Pages 1169-1181
Platelets and Renal Disorders....Pages 1183-1194
Platelets in Inflammatory Bowel Disease....Pages 1195-1207
Front Matter....Pages 1069-1069
Platelets and Neurodegenerative Diseases....Pages 1209-1224
Platelets and Diabetes....Pages 1225-1238
Front Matter....Pages 1239-1239
Aspirin....Pages 1241-1252
Glycoprotein IIb/IIIa Antagonists....Pages 1253-1267
Dipyridamole and PDE Inhibitors....Pages 1269-1281
PAR Antagonists....Pages 1283-1298
Inhibitors of Platelet Adhesion to VWF and Collagen....Pages 1299-1311
Pharmacogenomics of Antiplatelet Drugs....Pages 1313-1323
Targeting Intraplatelet Signaling Pathways as Potential Antithrombotic Strategy....Pages 1325-1340
Front Matter....Pages 1341-1357
Antiplatelet Therapy in Patients with Coronary Artery Disease....Pages 1359-1359
Antiplatelet Therapy in Cerebrovascular Disorders....Pages 1361-1371
Antiplatelet Therapy in Peripheral Artery Disease....Pages 1373-1380
Platelet Transfusions....Pages 1381-1390
Platelet-Rich Plasma in Regenerative Medicine....Pages 1391-1401
Therapeutic Use of Thrombopoietin Receptor Agonists....Pages 1403-1416
Gene Therapy....Pages 1417-1429
....Pages 1431-1445