Platelet-Activating Factor and Related Lipid Mediators 2: Roles in Health and Disease

Front Matter....Pages i-xiv
The Continuing Biochemical Challenge of PAF and Closely Related Lipid Mediators....Pages 1-3
Biosynthesis of Platelet-Activating Factor and Enzyme Inhibitors....Pages 5-10
Inhibitors of Arachidonate Metabolism and Effects on PAF Production....Pages 11-15
Production of Platelet-Activating Factor by Brain Microvascular Endothelial Cells....Pages 17-20
PAF-Synthesizing Enzymes in Neural Cells during Differentiation and in Gerbil Brain during Ischemia....Pages 21-27
Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors....Pages 29-32
The Role of Peroxisomes in Ether Lipid Synthesis....Pages 33-40
Platelet-Activating Factor Synthesis and Its Role in Salivary Glands....Pages 41-44
Physiological Action of PAF in Yeast Saccharomyces Cerevisiae ....Pages 45-50
Free Radical-Induced Oxidation of Glycerophosphocholine Lipids and Formation of Biologically Active Products....Pages 51-58
A Discovery Trip to Compounds with PAF-Like Activity....Pages 59-63
Biologically Active Lipids from S. Scombrus ....Pages 65-72
Purification and Partial Characterization of the PAF Antagonist from the Saliva of the Leech Hirudo Medicinalis ....Pages 73-77
Platelet-Activating Factor Receptor....Pages 79-84
Transcriptional Regulation of Platelet-Activating Factor Receptor Gene Expression in Leukocytes....Pages 85-87
PAF Receptor Anchors Streptococcus Pneumoniae to Activated Human Endothelial Cells....Pages 89-94
Up-Regulation of the Intracellular Ca 2+ Signaling and mRNA Expression of Platelet-Activating Factor Receptor by Estradiol in Human Uterine Endometrial Cells....Pages 95-100
Functional Role of Platelet-Activating Factor Receptor in Secretory Response in Adrenal Chromaffin Cells....Pages 101-105
Functional and Structural Features of Plasma Platelet-Activating Factor Acetylhydrolase....Pages 107-111
Acetylation of Sphingosine by PAF-Dependent Transacetylase....Pages 113-119
Platelet-Activating Factor Acetylhydrolase Activity in Human Follicular Fluid....Pages 121-127
The Prevention of Necrotizing Enterocolitis....Pages 129-133
Implication of PAF and Acetylhydrolase (PAF-AH) Activity in Periodontal Disease....Pages 135-141
Stimulation of NF-κB Activation and Gene Expression by Platelet-Activating Factor....Pages 143-151
Tyrosine Kinase Activation by PAF Leads to Downstream Gene Expression....Pages 153-155
Heterocyclic Alkylphospholipids with an Improved Therapeutic Range....Pages 157-164
Systemic Administration of Alkylphosphocholines....Pages 165-168
Arachidonate—Phospholipid Remodeling and Cell Proliferation....Pages 169-172
Protein Kinase C Inhibition by ET-18-OCH 3 and Related Analogs....Pages 173-180
Influence of Hexadecylphosphocholine (Miltefosine) on Cytokine Synthesis and Biological Responses....Pages 181-187
Effect of SM-12502 on Disseminated Intravascular Coagulation (DIC) in Tumor-Bearing Rats....Pages 189-193
Platelet-Activating Factor is an Effector of Rapid Reactions and an Inductor of Late Responses in Immune-Mediated Injury....Pages 195-199
Ether Lipid Metabolism, GPI Anchor Biosynthesis, and Signal Transduction are Putative Targets for Anti-Leishmanial Alkyl Phospholipid Analogues....Pages 201-211
PAF Response to Inflammatory and Non-Inflammatory Stimuli....Pages 213-216
Role of Platelet-Activating Factor in Skeletal Muscle Ischemia-Reperfusion Injury....Pages 217-221
Platelet-Activating Factor....Pages 223-230
Platelet-Activating Factor and Angiogenesis....Pages 231-234
Role of Synergistic Action of PAF and Kinin in Bacterial Endotoxin-Induced Hypotension in Rats....Pages 235-238
Epimer-Specific Actions of Hepoxilins A 3 and B 3 on PAF- and Bradykinin-Evoked Vascular Permeability in the Rat Skin in Vivo ....Pages 239-241
The Role of Platelet-Activating Factor in the Biocompatibility of Hemodialysis Membranes....Pages 243-248
Drug-Induced Alteration of Endothelial Permeability in the Rat Aorta....Pages 249-253
PAF Promotes the Development of the Preimplantation Embryo....Pages 255-261
PAF Released by Preimplantation Embryos Binds to Albumin....Pages 263-267
Role of Platelet-Activating Factor in Parturition....Pages 269-275
The Role of Platelet-Activating Factor and Its Receptor in Endometrial Receptivity....Pages 277-290
Non-Specific PAF Binding to Embryonal F9 Cells and Prostacyclin Synthesis in Human Umbilical Vein Endothelial Cells....Pages 291-295
Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions....Pages 297-304
Identification and Molecular Characterization of the CalB Domain of the Cytosolic Phospholipase A 2 (cPLA 2 ) in Human Neutrophils....Pages 305-308
Characterization of Plasmalogen-Selective Phospholipase A 2 from Bovine Brain....Pages 309-313
Structure and Function of Phospholipase A 2 Receptor....Pages 315-319
PAF-Induced MAPK Activation is Inhibited by Wortmannin in Neutrophils and Macrophages....Pages 321-326
Activation of 85 kDa PLA 2 by Eicosanoids in Human Neutrophils and Eosinophils....Pages 327-331
Phosphatidylcholine Biosynthesis as a Target for Phospholipid Analogues....Pages 333-336
Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans....Pages 337-342
Evidence for Activation of Cyclooxygenase-1/-2 by Endogenous Nitric Oxide in Adjuvant Arthritic Lewis Rats....Pages 343-348
Phosphatidylinositol-3-Kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)- and Phorbolester (PMA)-Challenged Human Neutrophils....Pages 349-353
Platelet-Type Arachidonate 12-Lipoxygenase....Pages 355-359
Lexipafant(BB-882), A Potent PAF Antagonist in Acute Pancreatitis....Pages 361-363
The Use of Lexipafant in the Treatment of Acute Pancreatitis....Pages 365-370
Effect of a Potent Platelet-Activating Factor Antagonist, WEB-2086, on Asthma....Pages 371-380
 Ex Vivo Inhibition of PAF-Induced β-Thromboglobulin Release in Man by ABT-299, a Potent PAF Antagonist....Pages 381-387
A Phase II Trial of Autologous Bone Marrow Transplantation (ABMT) in Acute Leukemia with Edelfosine Purged Bone Marrow....Pages 389-396
Back Matter....Pages 397-401