Pituitary Adenylate Cyclase Activating Polypeptide — PACAP

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Molecular Evolution of Pituitary Adenylyl Cyclase-Activating Polypeptide Subfamily and Cognate Receptor Subfamily....Pages 3-17
Occurrence, Distribution, and Physiological Function of Pituitary Adenylyl Cyclase-Activating Polypeptide in Invertebrate Species....Pages 19-31
PACAP-Like Compounds of Earthworms: Identification and Putative Functions from Embryonic Development to Brain Regeneration....Pages 33-42
PACAP and Learning in Invertebrates....Pages 43-50
Front Matter....Pages 51-51
PACAP and Neural Progenitor Cells....Pages 53-63
PACAP and Neural Development....Pages 65-82
PACAP Modulates Distinct Neuronal Components to Induce Cell-Specific Plasticity at Central and Autonomic Synapses....Pages 83-107
Front Matter....Pages 109-109
The Pharmacophoric Determinants of PACAP....Pages 111-132
PACAP-Derived Carriers: Mechanisms and Applications....Pages 133-148
Effects and Development of TAT-Tagged PACAP/VIP and Related Peptides....Pages 149-157
Front Matter....Pages 159-159
Presence and Role of PACAP in Endocrine Glands of Mammals....Pages 161-178
Distribution of PACAP in the Mammalian Nervous System....Pages 179-203
Multiple Mechanisms Contribute to the PAC1 Modulation of Parasympathetic Cardiac Neuron Excitability....Pages 205-225
PACAP in the Circadian Timing System: Learning from Knockout Models....Pages 227-237
The Role of PACAP in the Regulation of Body Temperature....Pages 239-257
Front Matter....Pages 259-259
PACAP Regulation of Gastrointestinal Function and Obesity....Pages 261-269
Protective Intestinal Effects of Pituitary Adenylate Cyclase Activating Polypeptide....Pages 271-288
Renoprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide 38 (PACAP38)....Pages 289-312
Neuroplasticity of PACAP Expression and Function in Micturition Reflex Pathways....Pages 313-334
Front Matter....Pages 335-335
Role of PACAP and VIP Signalling in Regulation of Chondrogenesis and Osteogenesis....Pages 337-353
Front Matter....Pages 335-335
Role of PACAP/VIP in Bone and Joint Physiology and Pathophysiology....Pages 355-372
Front Matter....Pages 375-375
Role of PACAP and Its PACAP Type I Receptor in the Central Control of Reproductive Hormones....Pages 375-387
Occurrence and Functions of PACAP in the Placenta....Pages 389-403
PACAP in the Reproductive System....Pages 405-420
Front Matter....Pages 421-421
Transport of Pituitary Adenylate Cyclase Activating Polypeptide Across the Blood–Brain Barrier: Consequences for Disease States and Therapeutic Effects....Pages 423-432
Effects of PACAP on Biological Barriers....Pages 433-447
Role of PACAP in Astrocytes and Astrocytic Tumors....Pages 449-458
Multiple Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Schwann Cell Biology....Pages 459-479
Front Matter....Pages 481-481
Sniffing Out a Role for PACAP in the Olfactory System....Pages 483-499
Protective Effects of PACAP in the Retina....Pages 501-527
Pituitary Adenylate Cyclase-Activating Polypeptide in the Auditory System....Pages 529-546
Front Matter....Pages 547-547
PACAP Signaling in Neuroprotection....Pages 549-561
PACAP Expression and Plasticity in the Peripheral Nervous System....Pages 563-582
The Neuropeptide PACAP, a Potent Disease Modifier Candidate for Brain Stroke Treatment....Pages 583-606
Front Matter....Pages 607-607
Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in Migraine Pathophysiology....Pages 609-615
PACAP Regulation of Vascular Tone: Differential Mechanism Among Vascular Beds....Pages 617-630
PACAP Circuits Mediating the Sensory and Behavioral Consequences of Pain....Pages 631-648
Front Matter....Pages 649-649
PACAP Modulation of CNS and Peripheral Inflammation....Pages 651-670
PACAP Regulation of Inflammatory and Free Radical Networks in Neuronal and Nonneuronal Diseases....Pages 671-690
Immunobiology of the Pituitary Adenylate Cyclase-Activating Peptide....Pages 691-708
Front Matter....Pages 709-709
PACAPergic Synaptic Signaling and Circuitry Mediating Mammalian Responses to Psychogenic and Systemic Stressors....Pages 711-729
Using PACAP Heterozygous Mice as Models of the Three Hit Theory of Depression....Pages 731-741
PACAP and Depression....Pages 743-756
Implications of PACAP Signaling in Psychiatric Disorders....Pages 757-766
Mechanisms of PACAP in PTSD and Stress-Related Disorders in Humans....Pages 767-780
PACAP, VIP, and ADNP: Autism and Schizophrenia....Pages 781-792
Front Matter....Pages 793-793
PACAP and Cancer....Pages 795-814
PACAP as a Potential Biomarker: Alterations of PACAP Levels in Human Physiological and Pathological Conditions....Pages 815-832
Examination of PACAP During Lactation....Pages 833-840