Physiology and Pathophysiology of the Heart

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Ultrastructure of Mammalian Cardiac Muscle....Pages 3-42
Basic Pathologic Processes of the Heart....Pages 43-57
Electrical Properties of Cells at Rest and Maintenance of the Ion Distributions....Pages 59-82
The Ionic Basis of Electrical Activity in the Heart....Pages 83-96
Electrogenesis of Pacemaker Potential as Revealed by AV Nodal Experiments....Pages 97-107
Cable Properties and Conduction of the Action Potential....Pages 109-140
The Electrocardiogram and Its Relationship to Excitation of the Heart....Pages 141-157
The Slow Action Potential and Properties of the Myocardial Slow Channels....Pages 159-186
Excitation-Contraction Coupling....Pages 187-198
The Role of Na-Ca Exchange in Heart....Pages 199-214
Methods for Detecting Calcium Release from the Sarcoplasmic Reticulum of Skinned Cardiac Cells and the Relationships Between Calculated Transsarcolemmal Calcium Movements and Calcium Release....Pages 215-254
Uptake of Calcium by the Sarcoplasmic Reticulum and Its Regulation and Functional Consequences....Pages 255-277
Contractile and Mechanical Properties of the Myocardium....Pages 279-299
Substrate and Energy Metabolism of the Heart....Pages 301-336
Neural Control of the Heart....Pages 337-354
The Development of Postsynaptic Cardiac Autonomic Receptors and Their Regulation of Cardiac Function During Embryonic, Fetal, and Neonatal Life....Pages 355-375
Mechanisms of Adrenergic and Cholinergic Regulation of Myocardial Contractility....Pages 377-404
The Pharmacology of the Cardiac Glycosides....Pages 405-419
Effects of and the Mechanism of Action of Calcium Antagonists and other Antianginal Agents....Pages 421-442
Cellular Electrophysiology and Ischemia....Pages 443-458
Front Matter....Pages 1-1
Mechanism of Action of Antiarrhythmic Drugs....Pages 459-476
Calcium and the Injured Cardiac Myocyte....Pages 477-492
Cell Coupling and Healing-Over in Cardiac Muscle....Pages 493-501
Effects of Cardiotoxins on Membrane Ionic Channels....Pages 503-519
Cardiac Hypertrophy and Altered Cellular Electrical Activity of the Myocardium....Pages 521-542
Developmental Changes in Membrane Electrical Properties of the Heart....Pages 543-573
Aging of the Adult Heart....Pages 575-592
Hormonal Effects on Cardiac Performance....Pages 593-603
Cardioplegia....Pages 605-616
The Effects of the Volatile Anesthetic Agents on the Heart....Pages 617-635
Front Matter....Pages 637-637
Effects of Toxic Substances on the Heart....Pages 639-658
Vascular Smooth Muscle Cells and Other Periendothelial Cells of Mammalian Heart....Pages 659-685
The Pathogenesis of Coronary Atherosclerosis....Pages 687-705
Electrophysiology of Vascular Smooth Muscle....Pages 707-736
Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle....Pages 737-747
Vascular Muscle Membrane Properties in Hypertension....Pages 749-756
Mechanical Properties, Contractile Proteins, and Regulation of Contraction of Vascular Smooth Muscle....Pages 757-779
Metabolism and Energetics of Vascular Smooth Muscle....Pages 781-795
Control of the Coronary Circulation....Pages 797-817
Coronary Artery Spasm....Pages 819-833
Back Matter....Pages 835-846