Pharmacology of Hormonal Polypeptides and Proteins: Proceedings of an International Symposium on the Pharmacology of Hormonal Polypeptides, held in Milan, Italy, September 14–16, 1967

Front Matter....Pages i-xi
Some New Methods in Peptide Synthesis....Pages 1-10
Novel Techniques in Peptide Synthesis....Pages 11-16
Synthetic polypeptides with enhanced biological activities....Pages 17-17
Synthesis of Gastrointestinal Hormones....Pages 18-31
The Synthesis of Caerulein....Pages 32-34
Techniques for the Synthesis of Acth And Msh Peptides and Analogues....Pages 35-47
Studies with Tryptophan in Solid-Phase Synthesis....Pages 48-52
Oxytocin — Molecular Aspects....Pages 53-65
Oxytocin and Vasopressin: Biochemical Considerations....Pages 66-72
Neurophysin, Oxytocin and Vasopressin in Neurosecretory Granules and in Crystalline Complexes....Pages 73-83
Mechanism of Release and Mechanism of Action of Vasopressin....Pages 84-92
Radioimmunoassay of Oxytocin....Pages 93-100
Comparison of the Pharmacological Properties of Two Highly Potent, Crystalline Neurohypophyseal Hormone Analogs: Deamino-1-Seleno-Oxytocin and Deamino-Oxytocin....Pages 101-104
Structure and Function of Pituitary Grafts, Related to the Problem of Hypothalamic Control of Hypophyseal Activity....Pages 105-111
The Physiology and Biochemistry of Luteinizing Hormone-Releasing Factor and Follicle Stimulating Hormone-Releasing Factor....Pages 112-122
Studies on the Isolation of Luteinizing Hormone Releasing Factor (LRF)....Pages 123-127
Studies on Luteinizing Hormone Releasing Factor (LRF) in Hypophysial Portal Blood of Rats....Pages 128-137
Studies on the Mechanism of Action of Hypothalamic FSH- and LH-Releasing Factors....Pages 138-147
Thyrotropin-Releasing Factor (TRF) of Hypothalamic Origin. A Review of Physiological and Biochemical Studies....Pages 148-157
Physiological and Biochemical Studies on Some Highly Purified Hypothalamic Releasing Factors....Pages 158-166
Role of the Cerebral Cortex in the Control of Acth Secretion....Pages 167-174
The Pharmacological Approach to the Study of the Mechanisms Regulating Acth Secretion....Pages 175-189
Effects of ACTH- and MSH-Peptides on Central Nervous System....Pages 190-195
Pharmacology of Synthetic Acth Peptides of Different Chain Lengths....Pages 196-202
Purification of Porcine and Human ACTH....Pages 203-212
The Mechanism of Action of Luteinizing Hormone on Steroidogenesis in the Corpus Luteum in Vitro ....Pages 213-222
Fate and Localization of Iodine-Labelled HCG in Mice....Pages 223-228
Human Follicle-Stimulating Hormone. Purification and Some Biological Properties....Pages 229-238
The Trend of Androgen Metabolites After Ovulation Induced by FSH and LH Fractions or by HCG Alone....Pages 239-241
Some Factors Influencing Suckling-Induced Prolactin Release in the Lactating Rat....Pages 242-253
Production of a Thyroid Stimulator by Immunizing Rabbits with Human Thyroid....Pages 254-262
A Comparative Study on the Mouse Thyroid Ultrastructure after Stimulation with TSH and LATS....Pages 263-270
Vasopressin Effect on Cortisol Incretion in Man....Pages 271-274
Pseudopregnancy after Monoamine Depletion in the Median Eminence of the Rat....Pages 275-277
The Synthesis of Insulin....Pages 278-296
Effects of Digestive Secretagogues on the Endocrine Pancreas in Man....Pages 297-303
Serum Insulin Response to Glucagon as an Index of Insulin Reserve....Pages 304-312
The Effect of Glucose, Glucagon, Arginine, Vasopressin and ACTH on Plasma Insulin and Growth Hormone Concentrations in Normal Children and in Pituitary Insufficiency....Pages 313-316
Insulin Secretion “In Vitro”: Comparative Aspects and Comparisons with Studies on Release of Insulin “In Vivo”....Pages 317-335
Reactivity of -S-S- Bonds in Relation with Insulin Biological Activity and Catabolism....Pages 336-350
The Physiologic Role of Glucagon....Pages 351-360
Sodium Dependency of Insulin-Stimulated Glucose Transport in Isolated Fat Cells.....Pages 361-366
The Role of Cyclic AMP in the Action of Insulin....Pages 367-376
Stimulation of Active Sodium Transport by Insulin....Pages 377-381
Distinct antagonistic effects of glucagon and insulin in the Embden-Meyerhof-chain....Pages 382-386
Selective Histochemistry of Glucagon in the a Cells of Pancreatic Islets by Indole Methods....Pages 387-395
Interrelationships Glucagon-Adrenergic System in Man Interest for the Diagnosis of Pheochromocytoma....Pages 396-400
Evolutionary Changes in Adipose Tissue Physiology....Pages 401-415
Aspects of Glucagon-Induced Lipolysis in Adipose Tissue....Pages 416-424
The Lipolytic Action of Catecholamines and Acth and the Interaction of Prostaglandin E 1 .....Pages 425-439
Lipid Mobilizing Peptide in Hog Pituitary and Human Urine....Pages 440-448
Study of the Lipolytic Effect of ACTH in Isolated Fat Cells of the Rat: Potentialization of the Lipolytic Effect by Adding Small Quantities of Serum of Guinea-Pig, Rat and Normal Man....Pages 449-455
The Anabolic Effects of Pituitary Growth Hormone....Pages 456-462
The Subcellular Distribution of Human Placental Lactogen....Pages 463-472
The Biological Characterization of Purified Placental Protein (Human) [PPP(H)]....Pages 473-482
Calcitonin....Pages 483-485
Biochemical Aspects of Hypotensive Peptide Action....Pages 486-496
Pharmacology of Angiotensin Antagonists....Pages 497-506
Effects of Angiotensin on Na and K Exchanges in Blood Vessels....Pages 507-516
Variations in the Aldosterone-Stimulating Activity of Angiotensin: Causes and Physiological Significance....Pages 517-526
Isolation and Structure of Caerulein....Pages 527-532
Pharmacological Data on Caerulein....Pages 533-540
“Vasodilating Action of Caerulein and I.C.I. 50,123 on the Canine Pancreatic Vascular Bed”....Pages 541-543
Studies on an Urinary Protein Factor of Gastric Antiulcer Activity (Urogastrone)....Pages 544-552
Biogenesis of Erythropoietin....Pages 553-562
Physico-Chemical and Biological Characteristics of Erythropoietin....Pages 563-568
Secretin, Cholecystokinin....Pages 569-580
Relationship between Behavioural Effect and Circulatory Changes Produced by Intra-Carotid Bradykinin....Pages 581-589
The Inflammatory Response and Polypeptides....Pages 590-594
Kinins in Chronic Inflammation....Pages 595-600
Adrenergic Receptors and Kinins....Pages 601-610
The Formation, Actions and Properties of Anaphylatoxin....Pages 611-619
Cholinergic Effects of Angiotensin and Bradykinin....Pages 620-625
On the Mechanism of Bradykinin Potentiation....Pages 626-631
Mechanism of Action of Relaxin....Pages 632-638
Comments on the Role of Plasma Kinins in Inflammation....Pages 639-640
Back Matter....Pages 641-660