Pharmacology of G Protein Coupled Receptors

Content: 
Copyright Page
Page iv

Contributors
Pages xi-xiii

Preface
Pages xv-xvi

Chapter 1 - The Use of GPCR Structures in Drug Design
Pages 1-36
Miles Congreve, Christopher Langmead, Fiona H. Marshall

Allosteric Modulation of Metabotropic Glutamate Receptors
Pages 37-77
Douglas J. Sheffler, Karen J. Gregory, Jerri M. Rook, P. Jeffrey Conn

Refining Efficacy: Exploiting Functional Selectivity for Drug Discovery
Pages 79-107
Diane Gesty-Palmer, Louis M. Luttrell

Pharmacological Chaperones for Misfolded Gonadotropin-Releasing Hormone Receptors
Pages 109-141
P. Michael Conn, Alfredo Ulloa-Aguirre

5 - Regulation of Stability and Trafficking of Calcium-Sensing Receptors by Pharmacologic Chaperones
Pages 143-173
Ying Huang, Alice Cavanaugh, Gerda E. Breitwieser

6 - Experimental Challenges to Targeting Poorly Characterized GPCRs: Uncovering the Therapeutic Potential for Free Fatty Acid Receptors
Pages 175-218
B.D. Hudson, Nicola J. Smith, Graeme Milligan

7 - Biological and Pharmacological Roles of HCA Receptors
Pages 219-250
Clara C. Blad, Kashan Ahmed, Ad.P. IJzerman, Stefan Offermanns

8 - Pharmacology, Signaling and Physiological Relevance of the G Protein-coupled Receptor 55
Pages 251-277
Nariman A.B. Balenga, Christopher M. Henstridge, Julia Kargl, Maria Waldhoer

9 - Role of PDZ Proteins in Regulating Trafficking, Signaling, and Function of GPCRs: Means, Motif, and Opportunity
Pages 279-314
Guillermo Romero, Mark von Zastrow, Peter A. Friedman

10 - Regulator of G Protein Signaling Proteins as Drug Targets: Current State and Future Possibilities
Pages 315-347
Benita Sjögren

11 - GPCR-Interacting Proteins, Major Players of GPCR Function
Pages 349-380
Pascal Maurice, Jean-Luc Guillaume, Abla Benleulmi-Chaachoua, Avais M. Daulat, Maud Kamal, Ralf Jockers

Index
Pages 381-390