Pharmacology of Antibiotics

Front Matter....Pages i-xiv
Tissue Binding of Antibiotics....Pages 1-5
The In Vivo Significance of Antibiotics in the Tissues....Pages 7-12
Antibiotic Concentrations in Human Interstitial Fluid....Pages 13-16
Antibiotic Activities Inside Leucocytes....Pages 17-23
Antibiotic Concentrations in Sinus Secretions....Pages 25-33
Antibiotics in Respiratory Secretions in the Experimental Animal....Pages 35-41
Antibiotic Concentrations in the Human Bone Marrow and Bone Marrow Hematoma....Pages 43-46
Passage of Doxycycline into the Thoracic Duct Lymph after Oral and Intravenous Administration in Man....Pages 47-52
Concentration of Antibacterials in Human Seminal Plasma....Pages 53-59
Antibiotic Concentrations in Intracranial Pus: A Study from a Collaborative Project....Pages 61-71
Concentrations of Antibiotics in Bronchiolar Secretions of the Patients with Chronic Respiratory Infections....Pages 73-78
Further Studies on the Protein Binding Inhibitor of Antimicrobials in Uremic Sera....Pages 79-83
Antimicrobial Therapy in Patients on Haemodialysis....Pages 85-92
Aging and Antimicrobial Therapy....Pages 93-100
Pharmacokinetics of Carbenicillin through Different Dialysis Membranes....Pages 101-105
The Effect of pH on the Transport of Oligosaccharidic Antibiotics across a Membrane Model System....Pages 107-114
Prolonged Excretion of Gentamicin in Patients with Normal Renal Function....Pages 115-120
The Use of Gentamicin in Patients with Impaired Renal Function....Pages 121-125
Comparative Biliary Excretion of Ampicillin, Metampicillin and Carbenicillin....Pages 127-140
Sisomicin: Serum Half-Life and Distribution Space in Patients with Normal and Impaired Renal Function....Pages 141-150
Serum Levels of Nalidixic Acid in Patients with Impaired Renal Function....Pages 151-158
Biotransformation of the Antibiotics in the Patients and Animals with Liver Impairment....Pages 159-164
Comparative Pharmacokinetics of Cephalosporins....Pages 165-170
Ten Years’ Experience with the Blood Level Duration Test....Pages 171-176
Statistical Aspects of the Blood-Level Duration Test....Pages 177-182
Effect of Recumbency on Erythromycin Absorption....Pages 183-190
Cholestyramine Induced Antibiotic Malabsorption....Pages 191-198
Investigation of the Gastrointestinal Absorption of Ampicillin, Cephalexin and Pivampicillin....Pages 199-203
Comparative Bioavailability of Oral Ampicillin Suspension, Pivampicillin Hydrochloride Salt (Capsule), Pivampicillin Pamoate Salt (Suspension) and Pivampicillin Probenecid Salt (Tablet) in Man....Pages 205-211
Biotransformation of Ampicillin, Amoxicillin, and Oxacillin in Healthy Subjects and in Patients with Bacteriuria....Pages 213-218
Antibiotic Absorption in Crohn’s Disease....Pages 219-229
A Pharmacokinetic Study of the Combination Rifampicin Plus Trimethoprim in Man....Pages 231-236
The Excretion and Metabolism of Talampicillin in Rat, Dog, and Man....Pages 237-241
The Excretion of Hetacillin Methoxymethyl Ester (BL-P1761) into the Prostatic Fluid of the Dog....Pages 243-247
Kidney Distribution of Carbenicillin, Indanyl Carbenicillin, Tobramycin, Fosfomycin and Cefazolin....Pages 249-253
Studies on Tissue Distribution of Antibiotics — An Attempt to Estimate Tissue Levels from Macro-Organisms....Pages 255-260
Immune Responsiveness to β Lactam Antibiotics....Pages 261-271
Rifampicin-Induced Antibodies....Pages 273-278
Possible Mechanisms in Pathogenesis of Nitrofurantoin-Induced Lung Disease....Pages 279-286
Assessing Untoward Effects....Pages 287-291
Antimicrobial Usage in the U.S.A.....Pages 293-297
Prospects for Control of Antibiotic Usage....Pages 299-305
Antibiotic Induced Diarrhoea & Colitis in Orthopaedic in-Patients....Pages 307-314
Abnormalities in the Fecal Flora of Subacute Myelo-Optic Neuropathy (SMON) Patients and Effects of Clioquinols on Human Intestinal Flora....Pages 315-320
Effect of Chloramphenicol on Phagocytic Activity in Human Polymorphonuclear Cells....Pages 321-326
The Effect of Rifampicin on Plasma Glutamyl Transpeptidase, Salicylamide Glucuronide Formation and D-Glucaric Acid Excretion....Pages 327-332
Side-Effects of High-Dose Dicloxacillin Therapy....Pages 333-338
Neurotoxicity of Different Penicillins and the Effect of Diazepam and Phenytoin on Penicillin-Induced Convulsions....Pages 339-344
Theoretical Basis and Experimental Studies on the Prevention of Allergic Reactions to Penicillins by a Monovalent Benzylpenicilloyl Hapten....Pages 345-349
Clinical Trial of a Monovalent Benzylpenicilloyl Hapten Inhibitor (Ro 6–0787) In Penicillin Allergy....Pages 351-357
Neuromuscular Blocking Activity of Aminoglycoside Antibiotics....Pages 359-365
Meningococcal Prophylaxis: Problems with Minocycline....Pages 367-371
Vibramycin Curing Symptoms and Enlargement of Thyroid Gland in Goiter....Pages 373-377
Chemotherapy of the Patients with Liver Diseases....Pages 379-384
Adverse Reactions under Intermittent Rifampicin Regimens....Pages 385-392
Pharmacokinetic and Pharmacological Interactions of Antibacterial Drugs....Pages 393-406
Drug Interactions in Chemotherapy....Pages 407-415
Interactions of Nitrofurantoin with Other Drugs in the Human Organism....Pages 417-421
In Vitro Studies of Chemical Interaction of Gentamicin or Tobramycin in Combination with Lincomycin or Clindamycin....Pages 423-427
Potentiation of Hepatic Damage by the Interaction of Tetracycline and Phenothiazine Derivatives: Therapy and Occurrance of New Psychiatric Symptomatology....Pages 429-433
Back Matter....Pages 435-436