Pharmacology and Functional Regulation of Dopaminergic Neurons: Proceedings of a Satellite Symposium of the IUPHAR 10th International Congress of Pharmacology, 31 August–2 September 1987

Front Matter....Pages i-xvii
The Status Quo and the Future....Pages 1-8
Structure-Activity Relationships for Benzazepines as D1-Specific Dopamine Antagonists....Pages 9-15
The Development of Potent and Selective D-2 Agonists of the 2-Aminotetralin Group: Their Clinical Applications and their Use in the Isolation of the D-2 Receptor....Pages 16-21
Dopaminergic Ergots....Pages 22-28
Autoreceptor Agonists....Pages 29-36
Structural Analyses Predict the Primary Pharmacophore and Secondary Sites for the D2 Receptor....Pages 37-42
Structure-Activity Relationship of Tetrahydroprotoberberines on Central Dopamine Receptors: (−)-Stepholidine—a New Antagonist of Dopamine Receptors....Pages 43-45
D1 and D2 Dopamine Receptors: Identification by Photoaffinity Labeling and Purification by Affinity Chromatography....Pages 46-51
D2 Dopamine Receptors: Isolation and Mechanism....Pages 52-58
Intracellular Ionic Changes Induced by Dopamine Receptor Stimulation in Mammotrophs: Evidence for a K+ Channel-linked Dopamine D-2 Receptor....Pages 59-68
Dopamine D-2 Receptor Agonists Decrease the Basal Level of Inositol 1,4,5-Trisphosphate in Rat Striatal Slices....Pages 69-76
D2 Receptor Activation Increases Potassium Conductance in Substantia Nigra Zona Compacta Neurones in vitro....Pages 77-83
Different States of the Dopamine D1 Receptor: Fact or Fantasy?....Pages 84-91
Purification of Receptors Binding Antipsychotics: Comparison with D2-Dopamine Receptor....Pages 92-95
Electrophysiological Investigation of D-1/D-2 Receptor Interactions in the Substantia Nigra and Basal Ganglia....Pages 96-102
Biochemical Insights into the D-1/D-2 Receptor Interactions....Pages 103-109
Dopamine D-1 and D-2 Receptor Differentiation Revealed by Behavioural Studies in Rats....Pages 110-116
New Selective D-1 and D-2 Dopamine Receptor Agonists as Further Probes for Behavioural Interactions between D-1 and D-2 Systems....Pages 117-123
Neurobiology of Supersensitive D1 and D2-Dopamine Receptors after 6-Hydroxydopamine Lesions....Pages 124-130
Dopamine D-1 and D-2 Receptor-mediated Inhibition and Excitation of Caudate Neurons Induced by Respective High and Low Concentrations of Dopamine in vitro....Pages 131-133
Long-term Apomorphine Produces both Supersensitive and Subsensitive Responses to D1 and D2 Receptor Agonists....Pages 134-145
‘Priming’ Phenomena in the Expression of D1 and D2 Receptor Supersensitivity....Pages 146-148
Regulation of Striatal D1 Dopamine Receptor Density by D1 and D2 Antagonists....Pages 149-151
Endogenous Dopamine Release from Brain Slices: Comparisons with Radiolabelled Release and Regulation by Autoreceptors....Pages 152-160
Regulation of Dopamine Release by Muscarinic Receptors....Pages 161-167
Repeated Cocaine Administration Results in Supersensitive Nigrostriatal D-2 Dopamine Autoreceptors....Pages 168-174
Functional Presynaptic D-2 and Postsynaptic D-1 Dopamine Receptors in the Central Nervous System....Pages 175-177
Use of Brain Dialysis in Freely Moving Rats for Characterizing the Profile of Dopamine-receptor Agonists....Pages 178-186
Comparison of EMD 38362, (+)3-PPP, (−)3-PPP and BHT 920 in Pre- and Postsynaptic Models for D2-Activity: Discrepancies between in vivo and in vitro Results....Pages 187-190
D-1 Agonist Co-treatment Uncovers Postsynaptic Dopamine (DA) Receptor Stimulatory Properties of B-HT 920, a Putative DA (D-2) Autoreceptor-selective Agonist....Pages 191-193
Modulation of the Sensitivity of Synaptosomal Dopamine Autoreceptors to Bromocriptine by in vitro and in vivo Treatments....Pages 194-196
Functional Specificity of Nigral Grafts in Dopamine-depleted Rats....Pages 197-203
Genetic and Toxin-induced Depletion of Striatal Dopamine....Pages 204-210
Functional Significance of Long-term Receptor Hetero-regulation: Further Evidence for Dopaminergic Cortico-subcortical Relationships....Pages 211-218
Gabaergic Mechanisms after Manipulation of Striatal Dopaminergic Neurons....Pages 219-225
Inhibition and Excitation Mediated Respectively by Dopamine D-1 and D-2 Receptors on the Caudate Nucleus Neurons Receiving Dopaminergic Input from the Substantia Nigra: Microiontophoretic and in vitro Studies....Pages 226-228
Dopamine-containing Neurons: Intracellular Analysis and Characterization....Pages 229-235
Lack of Cholinergic Modulation of Mesolimbic Dopamine Function....Pages 236-238
Calcium Antagonists, Neuroleptics and Brain Dopamine....Pages 239-241
Unique Effects of Long-term Clozapine, but not Haloperidol, on Dopamine Transmission in the Amygdaloid Complex....Pages 242-244
Effect of Methamphetamine on in vivo Release of Dopamine and its Metabolites from the Striatum in Freely Moving Rats....Pages 245-247
Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine....Pages 248-250
The Distribution of Catecholamine Uptake Sites in Mouse Brain....Pages 251-253
Changes in Brain Dopamine Metabolism During Withdrawal from Chronic Oral Self-administration of Morphine, and in Response to a Morphine Challenge in the Withdrawn State....Pages 254-256
Further Evidence for Neurotensin-Dopamine Interactions in the Central Nervous System....Pages 257-265
Interactions between Cholecystokinin and Dopamine: Electrophysiological Studies....Pages 266-272
CCK Receptors and Brain Dopaminergic Systems....Pages 273-281
Dopaminergic Modulation of Striatal Tachykinin Biosynthesis....Pages 282-288
Comparison of the Effects of Restraint Stress on the Activities of Tuberoinfundibular and Tuberohypophysial Dopaminergic Neurons....Pages 289-295
The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation....Pages 296-302
Regulation of Dopamine Receptor Responsiveness by Glucocorticoids....Pages 303-305
The Effect of Dopamine (D-1 and D-2) Agonists and Antagonists on Fixed-interval Self-stimulation....Pages 306-311
The Cardiovascular Pharmacology of Dopexamine Hydrochloride....Pages 312-314
Pressor Effects of Electrical Stimulation of the Rat Ventral Tegmental A10 Dopamine System....Pages 315-317
Control of Human Placental Lactogen Secretion by Dopamine....Pages 318-320
Neuronal Compensation and Age as Factors Affecting MPTP-induced Parkinsonism in the Common Marmoset....Pages 321-328
Imaging of Pre- and Post-synaptic Adaptations in the Nigrostriatal Dopaminergic System of MPTP-induced Parkinsonism....Pages 329-335
Effects of Copper-chelating Agents and Alcohol-sensitizing Drugs on MPTP-induced Neurotoxicity in Mice....Pages 336-342
Monoamine Oxidase-A and -B and the Bioactivation of MPTP-like Neurotoxins....Pages 343-349
Effect of Chronic Levodopa, Bromocriptine and SKF-38393 on Dyskinesia and Dopamine Receptors in MPTP-parkinsonian Monkeys....Pages 350-352
Fetal Substantia Nigra Transplants Lead to Dopamine Cell Replacement and Behavioral Improvement in Bonnet Monkeys with MPTP Induced Parkinsonism....Pages 353-360
Roles of MAO-A and -B in the Metabolism of DA and the Oxidation of MPTP-like Compounds....Pages 361-363
Dopamine Receptor Subtypes: Differential Regulatory Characteristics and Levels in Schizophrenia....Pages 364-370
Brain Dopamine Receptors in Normal Aging, Alzheimer’s Disease and Parkinson’s Disease....Pages 371-373
Functional Markers of Dopaminergic Transmission in Post-mortem Brain in Schizophrenia....Pages 374-376
Dyskinesia in Parkinson’s Disease. An Interim Report on the Sydney Multi-centre Long-term Study of Parkinson’s Disease....Pages 377-383
Back Matter....Pages 385-391