Pharmacological Aspects of Heart Disease: Proceedings of an International Symposium on Heart Metabolism in Health and Disease and the Third Annual Cardiology Symposium of the University of Manitoba, July 8–11, 1986, Winnipeg, Canada

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Approaches to the Selection of an Antiarrhythmic Drug....Pages 3-16
Antiarrhythmic Action of Calcium Antagonists....Pages 17-31
Quinidine Reduces Outward Current in Single Canine Cardiac Purkinje Cells....Pages 33-44
Antiarrhythmic Drug Therapy for Patients with Ventricular Tachyarrhythmias in the Setting of Left Ventricular Dysfunction: 1. The Role of Propafenone 2. The Role of Adjunct Beta-Blockade....Pages 45-57
Protective Effect of Nifedipine upon Ouabain-Induced Arrhythmias....Pages 59-73
Effect of Isoprenaline or Stress on Adrenaline-Induced Arrhythmias in Albino Rats....Pages 75-86
Front Matter....Pages 87-87
Clinical Trials in Hypertension and Congestive Heart Failure....Pages 89-95
Interaction of Calcium Entry Blockers and Adrenergic System in Hypertension and Heart Failure....Pages 97-107
Prazosin Therapy in Chronic Congestive Heart Failure....Pages 109-118
Influences of a Long-Term Treatment with Antihypertensive Drugs on Left Ventricular Myosin Isoenzyme Pattern in Spontaneously Hypertensive Rats....Pages 119-124
Enhanced Action of Nifedipine upon Vascular Smooth Muscle from Hypertensive Rats....Pages 125-136
Ajmaloon a Unique Herbal Polypharmaceutical Possessing Both Hypotensive and Cadmium Lowering Property....Pages 137-150
Pathophysiology and Treatment of Decreased Cardiac Output Complicating Pulmonary Hypertension....Pages 151-161
Front Matter....Pages 163-163
Ca Antagonists in Cardiopulmonary Changes Induced by High Altitude Hypoxia....Pages 165-177
Effect of Crystalloid Cardioplegia and Diltiazem on the Cardiac Function and Some Biochemical Parameters During Hypothermic Cardiac Arrest Using Cardiopulmonary Bypass....Pages 179-194
Effects of Verapamil on Metabolism and Function of Hearts from Normal and Hyperthyroid Rats....Pages 195-203
Regulation of Beta-Adrenergic Pathways in the Heart....Pages 205-216
Involvement of ß 2 -Adrenergic Receptors in the Potentiation of the Chronotropic Action of Isoprenaline Evoked in Rocker-Cultured Neonatal Rat Heart Cells by Pyruvate and L(+)-Lactate....Pages 217-231
Cardiac Effects of ß-Adrenergic Blockers in Combination with Metabolic Interventions....Pages 233-247
Local Adrenergic Effects on Metabolism in Heart and Skeletal Muscle in Man....Pages 249-257
Front Matter....Pages 259-259
Multiple Forms of the Cardiac Glycoside Receptor with Different Affinities for Cardiac Glycosides....Pages 261-271
Modulation of Glycoside Sensitivity of the Cardiac Sodium Pump....Pages 273-284
Up and Down Regulation of the Sodium Pumping Sites in Myocardium....Pages 285-298
Sensitivity of the Hypertrophied Heart to Ouabain. An in vivo and in vitro Study....Pages 299-312
Mitochondrial Calcium Overload in Digitalis-Induced Mechanical Toxicity....Pages 313-327
Front Matter....Pages 329-329
Classification and Mechanism of Action of the Cardiac Inotropic Agents: An Overview....Pages 331-340
New Approaches for the Treatment of the Failing Myocardium: Myofibrillar Proteins as Potential Targets for Pharmacotherapy....Pages 341-352
The Role of the Lipid Bilayer in Amphiphile-Membrane/Receptor Interactions: A Unifying Hypothesis....Pages 353-365
Forskolin, A New Inotropic Agent....Pages 367-374
Dependence of Vasoconstrictor Responses on Extracellular Calcium....Pages 375-388
Cytosolic Free Calcium Transients Induced by Ergonovine in Cultured Vascular Smooth Muscle Cells....Pages 389-393