Pharmaceutical Dosage Forms vol 1: Disperse Systems

Cover......Page 1
Half Title......Page 2
Title Page......Page 4
Copyright Page......Page 5
Preface to the Second Edition......Page 6
Preface to the First Edition......Page 8
Table of Contents......Page 10
Contributors......Page 14
Contents of Volumes 2 and 3......Page 16
Contents of Pharmaceutical Dosage Forms: Tablets, Second Edition, Revised and Expanded, Volumes 1-3......Page 18
Contents of Pharmaceutical Dosage Forms: Parenteral Medications, Second Edition, Revised and Expanded, Volumes 1-3......Page 20
 I. Overview......Page 22
 II. Free Energy Considerations......Page 24
 III. Stability Considerations......Page 29
 IV. Protocols......Page 34
 References......Page 35
 II. Classification of Dispersed Systems......Page 38
 III. Particle Properties......Page 39
 IV. The Solid-Liquid Interface......Page 47
 V. Preparation......Page 51
 VI. Stabilization......Page 53
 VII. Rheological Aspects......Page 64
 VIII. Effect of Additives......Page 67
 Appendix I: Typical Particle Size Devices......Page 69
 Appendix II: Mixing Equipment: Manufacturers and Devices......Page 70
 References......Page 71
 I. Introduction......Page 74
 II. General Aspects of Emulsions......Page 75
 III. Stability of Two-Phase Emulsions......Page 81
 IV. Stability of Three-Phase Emulsions......Page 96
 Appendix: Flocculation Kinetics of Spherical Particles or Droplets......Page 108
 References......Page 110
 I. Introduction......Page 112
 II. Electrostatic Stabilization of Latexes......Page 114
 III. Steric Stabilization of Latexes......Page 133
 IV. Preparation of Latexes by Direct Emulsification......Page 146
 References......Page 163
 I. Introduction......Page 174
 II. Fundamentals......Page 175
 III. Elasticity and Viscosity......Page 177
 IV. Viscometry......Page 200
 V. Rheology of Dispersed Systems......Page 219
 References......Page 228
 I. Definitions and General Properties of Surfactants......Page 232
 II. Physical Description of Surfactants in Solution......Page 234
 III. Chemical Description of Surfactants......Page 247
 IV. Special Topics......Page 271
 V. Biological Effects of Surfactants......Page 280
 VI. Use of Surfactants in Drug Products......Page 286
 VII. Effect of Surfactants on Drug Efficacy......Page 292
 Appendix: Practical Examples......Page 298
 References......Page 302
 I. Introduction......Page 308
 II. Polymer Solution Rheology......Page 309
 III. Sedimentation Control in Disperse Systems......Page 310
 IV. Viscosity Changes During Product Aging......Page 311
 V. Flocculation and Deflocculation Phenomena......Page 312
 VI. Excipient Compatability......Page 315
 VII. Polymer Selection......Page 316
 VIII. Viscosity-Building Substances......Page 317
 IX. Sample Formulations......Page 330
 References......Page 333
 I. Introduction......Page 336
 II. Formulation Factors Affecting Drug Release from Disperse Systems......Page 337
 III. Principles of Drug Release from Disperse Systems......Page 338
 IV. In Vitro-In Vivo Correlations......Page 345
 V. Physiological Factors Affecting Bioavailability......Page 346
 VI. Methods of Assessing Drug Bioavailability......Page 349
 VII. In Vivo Bioavailability Assessment......Page 359
 References......Page 391
 I. Overview......Page 398
 II. General Characteristics......Page 400
 III. Microbial Contamination......Page 403
 IV. Preservatives......Page 409
 V. Effects of Product Ingredients on Preservative Activity......Page 428
 VI. Evaluation of Preservative Efficacy......Page 433
 VII. Future Trends......Page 446
 References......Page 451
 I. Introduction......Page 458
 II. Deterministic Modeling......Page 459
 III. Stochastic Modeling......Page 528
 IV. Concluding Remarks......Page 534
 References......Page 535
Index......Page 542