Perspectives in Inflammation: Future Trends and Developments

Front Matter....Pages i-xxi
Front Matter....Pages 1-10
The rationale of using levamisole in the treatment of rheumatoid arthritis....Pages 11-20
Immunostimulation, levamisole and rheumatoid arthritis....Pages 21-27
The effect of cytotoxic drugs on the formation of mononuclear phagocytes....Pages 29-37
Rheumatoid factor-immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation....Pages 39-48
Front Matter....Pages 61-67
A model for assessing effects of drugs on granulocyte emigration in vivo ....Pages 69-74
A polymorph abnormality in Crohn’s disease....Pages 75-79
The origin and kinetics of liver macrophages during steady state and inflammation ( Abstract )....Pages 81-83
Lymphocyte-mediated eosinophilia in guinea pigs with delayed hypersensitivity to a chemical....Pages 85-100
A role for L-lymphocytes in chronic inflammation....Pages 101-113
Cartilage degradation by macrophages, fibroblasts and synovial cells in culture. An in vitro model suitable for studies on rheumatoid arthritis....Pages 115-129
Adjuvant arthritis: immune responses and effects of Tilorone or interferon in partially suppressing the disease....Pages 131-146
Front Matter....Pages 161-167
The effect of local elevation of leukocyte cyclic AMP content on lysosomal enzyme release during acute inflammation in vivo ....Pages 169-178
Recent studies on the secretory activity of mononuclear phagocytes with special reference to prostaglandins....Pages 179-189
Interactions of macrophages and complement components in the pathogenesis of chronic inflammation....Pages 191-209
Matrix vesicles and apatite nodules in arthritic cartilage....Pages 211-223
Crystal induced inflammation and osteoarthritis....Pages 225-231
Microanalysis of particulate material involved in inflammation....Pages 233-237
The influence of chemical composition of plasma membranes on the functional activities of macrophages....Pages 239-250
Front Matter....Pages 263-263
Dual function of E-type prostaglandins in models of chronic inflammation....Pages 265-277
Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease....Pages 279-288
Front Matter....Pages 263-263
The time course of the vascular events associated with inflammation due to ultraviolet irradiation of guinea pig ears....Pages 289-294
Role of macrophages in D-penicillamine-induced stimulation of DNA synthesis in lymph node cells....Pages 295-302
Anti-inflammatory effects of tumour bearing....Pages 303-316
Role of platelets and of prostaglandin synthetase on hypotensive effects of arachidonic acid and of carrageenan....Pages 317-330
Evidence for a pivotal role of the endoperoxide, PGG 2 , in inflammatory processes....Pages 331-337
Thiols and prostaglandin biosynthesis....Pages 339-345
Interactions of non-steroidal anti-inflammatory drugs with substance P-like and gastrointestinal hormones-like polypeptides....Pages 347-352
Salicylic acid and proquazone: the differences in absorption and biodistribution explain their different profile of side-effects....Pages 353-360
Degradation of bovine nasal cartilage by a neutral protease from human leukocyte granules....Pages 361-370
Inhibition of experimental ocular inflammation by topical application of non-steroidal anti-inflammatory drugs (NSAID)....Pages 371-381
Potentiation of acenocoumarin-induced anticoagulation by a new anti-inflammatory agent in man (Abstract) ....Pages 383-385
 In vitro methods for assessing anti-inflammatory drug activity (Abstract) ....Pages 387-389
Front Matter....Pages 391-391
Potentiation of antibody formation by proteases in vivo ....Pages 393-398
Triggers of prostaglandin release from macrophages....Pages 399-404
Biological, chemical and pharmacological induction of the properdin-mediated pathway of complement activation in vitro ....Pages 405-416
Immune reactions of lymphocytes eluted from rheumatoid inflammatory tissue....Pages 419-426
Attempts at producing immune complexes in vitro between isolated macroglobulins and purified IgGs....Pages 427-434
Behaviour of some inflammation parameters in plasma and synovial fluid in some rheumatic diseases ( Abstract )....Pages 435-436
Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systemic acute-phase reaction of the rat....Pages 437-444
Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E....Pages 445-454
Front Matter....Pages 391-391
Rheumatoid-like joint lesions in rabbits injected intravenously with foreign serum....Pages 455-459
Anti-inflammatory activity of some bacterial immunostimulants. Relation with macrophage migration....Pages 461-468
Inflammatory exudates and mitogenic activity....Pages 469-479
Secretory activity of epithelioid cells....Pages 481-490
Vascular changes during acute inflammatory responses in rat hindpaws....Pages 491-495
Front Matter....Pages 497-497
Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation....Pages 499-505
Relationships between increased vascular permeability, oedema, hyperalgesia and the effect of non-steroid anti-inflammatory drugs....Pages 507-518
Two sites of action of steroids on the prostaglandin system....Pages 519-525
Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein)....Pages 527-544
Humoral control of monocytopoiesis ( Abstract )....Pages 545-547
Front Matter....Pages 557-560
Difficulties in the clinical evaluation of new anti-inflammatory drugs....Pages 561-573
Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?....Pages 575-583
About immunological anomalies in treated and non-treated rheumatoid arthritis: rosette test and immunofluorescence of B-cells....Pages 585-590
Should penicillamine be prescribed for rheumatoid arthritis?....Pages 591-597
Long-term evaluation of intermittent levamisole treatment in rheumatoid arthritis....Pages 599-609
Back Matter....Pages 619-638