Perspectives in Antiinfective Therapy

Front Matter....Pages I-XVII
The Challenge of Perspective....Pages 1-4
History and Philosophy of Bayer Parmaceutical Research....Pages 5-11
On Bacteriological Research....Pages 13-17
Background to Robert Koch’s Lecture at the International Congress in Berlin, 1890....Pages 19-21
Front Matter....Pages 23-23
Multiple Penicillin Binding Protein Profiles in Penicillin Resistant Pneumococci: Evidence for the Clonal Nature of Resistance Among Clinical Isolates....Pages 25-41
Antibiotic Uptake into Gram-Negative Bacteria....Pages 42-53
Inhibition of Protein Biosynthesis by Antibiotics....Pages 54-72
Inhibition of DNA Gyrase: Bacterial Sensitivity and Clinical Resistance to 4-Quinolones....Pages 73-84
Front Matter....Pages 85-85
Mechanisms of Antiretroviral Compounds in Inhibition of Viral and Cellular DNA Polymerases....Pages 87-99
Effects of Drugs on Lipids and Membrane Integrity of Fungi....Pages 100-111
Membrane Changes Induced by Praziquantel....Pages 112-123
Mechanisms of Action of Antimalarial Drugs....Pages 124-143
Front Matter....Pages 145-145
Bacterial Adherence in Pathogenicity....Pages 147-155
 Haemophilus influenzae Gene Expression and Bacterial Invasion....Pages 156-162
Coordinate Regulation of Bacterial Virulence Genes....Pages 163-174
Front Matter....Pages 175-175
Transposon Transfer of Drug Resistance....Pages 177-185
Bacterial Proteins Involved in Antimicrobial Drug Resistance....Pages 186-195
Persistent Herpes Simplex Virus Infection and Mechanisms of Virus Drug Resistance....Pages 196-212
Front Matter....Pages 213-213
Antiviral Therapy with Small Particle Aerosols....Pages 215-233
Liposomes and Lipid Structures as Carriers of Amphotericin B....Pages 234-244
Front Matter....Pages 213-213
Targeted Liposomes Bearing Sendai for Influenza Envelope Glycoproteins as a Potential Carrier for Protein Molecules and Genes....Pages 245-260
Front Matter....Pages 261-261
Cell-Mediated Immunity, Immunodeficiency and Microbial Infections....Pages 263-277
Neutropenia: Antibiotic Combinations for Empiric Therapy....Pages 278-284
Infection Prevention by Modulation of the Host Flora....Pages 285-294
Enhancement of Resistance in the Immunocompromised Host by Control of Fungal Growth....Pages 295-307
Front Matter....Pages 309-309
Passive Immunotherapy of Infectious Diseases: Lessons from the Past, Directions for the Future....Pages 311-319
T-Cell Mediated Immunopathology in Viral Infections....Pages 320-326
Front Matter....Pages 327-327
Adherence and Proliferation of Bacteria on Artificial Surfaces....Pages 329-338
Current Knowledge of Chlamydia TWAR, an Important Cause of Pneumonia and Other Acute Respiratory Diseases....Pages 339-359
Current Status of Antiviral Chemotherapy for Genital Herpes Simplex Virus Infection: Its Impact on Disease Control....Pages 360-368
Induction and Maintenance Therapy for Opportunistic Infections in Patients with AIDS....Pages 369-372
Front Matter....Pages 373-373
Nucleic Acid Hybridization: A Rapid Method for the Diagnosis of Infectious Diseases....Pages 375-385
New Technology and Immunospecific Reactions in Helminthic Diseases....Pages 386-395
Molecular Targets of Chemotherapeutic Agents Against the Human Immunodeficiency Virus....Pages 396-418
Modern Strategies in the Design of Antimicrobial Agents....Pages 419-435
Front Matter....Pages 437-437
The Future Challenge of Infectious Disease....Pages 439-443
Barriers to Effective Antiinfective Therapy: The Perspective of a Clinical Pharmacologist....Pages 444-450
Optimal Use of Antimicrobial Agents....Pages 451-460
Views of Future Antiinfective Therapy....Pages 461-468
Back Matter....Pages 469-478