Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods

Cover
Half Title
Series Page
Title Page
Copyright Page
Contents
Editors
Contributors
Chapter 1: Molecular Structure and Function of the Skin Barrier
Chapter 2: Mathematical Models in Percutaneous Absorption
Chapter 3: In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/Vehicle Partitioning
Chapter 4: The Skin Reservoir for Topically Applied Solutes
Chapter 5: Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying the Interaction of Chemicals and Human Skin
Chapter 6: Variations of Hair Follicle Size and Distribution in Different Body Sites
Chapter 7: In Vivo Relationship between Percutaneous Absorption and Transepidermal Water Loss
Chapter 8: The Correlation between Transepidermal Water Loss and Percutaneous Absorption: An Updated Overview
Chapter 9: Human Percutaneous Absorption and Transepidermal Water Loss (TEWL) Correlation
Chapter 10: Evaluation of Stratum Corneum Heterogeneity
Chapter 11: Regional Variation in Percutaneous Absorption: Principles and Applications to Human Risk Assessment
Chapter 12: Effects of Anatomical Location on In Vivo Percutaneous Penetration in Man
Chapter 13: Interrelationships in the Dose Response of Percutaneous Absorption
Chapter 14: Effects of Occlusion: Percutaneous Absorption
Chapter 15: Occlusion Does Not Uniformly Enhance Penetration In Vivo
Chapter 16: Effect of Single versus Multiple Dosing in Percutaneous Absorption
Chapter 17: Influence of Formulation on Topical and Transdermal Drug Delivery
Chapter 18: In Vitro Release from Semisolid Dosage Forms: What Is Its Value?
Chapter 19: Understanding Skin Metabolism–Effect on Altering In Vitro Skin: Absorption and Bioavailability of Topically Applied Chemicals
Chapter 20: Phenomenon of Lateral Spread in Percutaneous Penetration
Chapter 21: Clinically Pertinent Factors/Observations Affecting Percutaneous Absorption in Humans
Chapter 22: Percutaneous Absorption of Chemical Mixtures
Chapter 23: Dermal Decontamination and Percutaneous Absorption
Chapter 24: Skin Decontamination 2020 Update
Chapter 25: Chemical Warfare Agent VX Penetration through Military Uniform and Human Skin: Risk Assessment and Decontamination
Chapter 26: Percutaneous Absorption of Hazardous Chemicals from Fabric into and through Human Skin
Chapter 27: Percutaneous Absorption of Chemicals from Fabric (Textile)
Chapter 28: The Fate of Material Remaining in Skin in In Vitro Absorption Studies
Chapter 29: Skin Absorption of Hair Dyes
Chapter 30: Hair Dye Penetration in Monkeys and Human Beings
Chapter 31: Percutaneous Absorption of Sunscreens
Chapter 32: Sunscreen Percutaneous Penetration In Vivo in Man
Chapter 33: Cutaneous Metabolism of Xenobiotics
Chapter 34: Chemical Modification: An Important and Feasible Method for Improving Peptide and Protein Dermal and Transdermal Delivery
Chapter 35: Percutaneous Penetration of Oligonucleotide Drugs
Chapter 36: Use of Microemulsions for Topical Drug Delivery
Chapter 37: Transdermal Delivery of Vesicular Nanocarriers under Electrical Potential
Chapter 38: Lipid-Based Vesicles (Liposomes) and Their Combination with Physical Methods for Dermal and Transdermal Drug Delivery
Chapter 39: Assessment of Microneedles for Transdermal Drug Delivery
Chapter 40: Clinical Testing of Microneedles for Transdermal Drug Delivery
Chapter 41: Delivery of Drugs, Vaccines, and Cosmeceuticals to Skin Using Microneedle Patches
Chapter 42: Microneedle Dermatotoxicology
Chapter 43: Transdermal Transport by Sonophoresis
Chapter 44: Effect of Tape Stripping on Percutaneous Penetration and Topical Vaccination
Chapter 45: Transcutaneous Delivery of Drugs by Electroporation
Chapter 46: Iontophoresis in Penetration Enhancement
Chapter 47: Vehicles and Topical Therapy
Chapter 48: The Role of In Vitro Skin Models in Optimization of Dermal Drug Delivery
Chapter 49: Effects of Phospholipids on Skin: Use of Primary Human Keratinocytes and Fibroblasts as 2D Cell Culture Models
Chapter 50: Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Effects of Heat Separation and Freezing
Chapter 51: Determination of Percutaneous Absorption by In Vitro Techniques
Chapter 52: Stripping Method for Measuring Percutaneous Absorption In Vivo
Chapter 53: Tape Stripping: Technique and Applications
Chapter 54: Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques
Chapter 55: Confocal Raman Microspectroscopy in the Assessment of Skin Barrier Function and Drug Penetration
Chapter 56: Microscopy Methods for Assessing Percutaneous Drug Penetration: Percutaneous Absorption-Drugs-Cosmetics-Mechanism-Methodology
Chapter 57: Dermal Sampling Techniques with a Focus on Dermal Open Flow Microperfusion
Chapter 58: Dermal-Epidermal Separation Methods: Research Implications
Chapter 59: Use of Skin Absorption Data in the Safety Evaluation of Cosmetic Ingredients
Chapter 60: Bioequivalence, Pharmaceutical Equivalence, and Biowaivers: Topical Dosage Forms for Local Action
Chapter 61: In Vitro Human Nail Model to Evaluate Ungual Absorption and Transungual Delivery
Chapter 62: Drug Permeation through Burn Eschar: Possibilities and Improvements
Chapter 63: Percutaneous Penetration in Humans: Transfer of Chemicals via Skin-to-Skin Contact
Chapter 64: Nanoparticles and Their Combination with Physical Methods for Dermal and Transdermal Drug Delivery
Index