Pathophysiology of Heart Failure

Front Matter....Pages i-xli
Front Matter....Pages 1-1
Experimental Models of Heart Failure and Cardiomyopathy....Pages 3-8
Role of Tissue and Circulating Substance P in Cardiovascular Injury Associated with Mg-Deficiency....Pages 9-19
Functional and Metabolic Effects of Norepinephrine on the Rat Heart....Pages 21-29
Interventions in Experimentally Induced Diabetic Cardiomyopathy....Pages 31-45
Diabetes as a Risk Factor for Cardiovascular Disease: Experimental Models....Pages 47-75
Ethanol-Induced Hypertension: The Role of Acetaldehyde....Pages 77-93
Abnormalities in Cardiac Contractile Proteins and Cardiac Dysfunction....Pages 95-108
Role of the Slow Sodium Channel in Hereditary Cardiomyopathy....Pages 109-125
Cardiac Contractile Failure Caused by Disturbances in Myofibrillar Energy Supply and Pathogenesis of Cardiomyopathies....Pages 127-138
Changes in Contractile Proteins under Oxidative Stress....Pages 139-147
Antioxidants and the Heart....Pages 149-170
Gene Expression of Cardiac Myocytes: A Pharmacologic Target for the Failing Heart?....Pages 171-188
Front Matter....Pages 189-189
Regulation of Slow Ca 2+ Channels of Myocardial Cells by Cyclic Nucleotides and Phosporylation....Pages 191-223
Multiple Roles for the Membrane-Associated Ca 2+ /Calmodulin-Dependent Protein Kinase in the Regulation of Sarcoplasmic Reticulum Function in Heart Muscle....Pages 225-243
Calreticulin, a Multifunctional Ca 2+ Binding Protein of Smooth Muscle Sarcoplasmic Reticulum Membranes....Pages 245-251
Intracellular Ca 2+ Transients in Response to Step Length Changes in Aequorin-Injected Ferret Papillary Muscles....Pages 253-261
Initial Changes in β-Adrenergic Receptor Function during Development of Rapid Ventricular Pacing-Induced Heart Failure....Pages 263-276
Impaired Cellular Signaling of the Adenylyl Cyclase and the Phosphoinositide Pathway in Septic Cardiomyopathy....Pages 277-310
Defective G-Protein Expression and Adenylyl Cyclase in Genetic and Experimental Hypertension....Pages 311-329
Electrophysiological Studies of Wild-Type and Mutant Na + -Ca 2+ Exchange Proteins....Pages 331-342
Front Matter....Pages 189-189
Cardiac Sarcolemmal Na + /H + Exchange after a Myocardial Infarction in the Rat....Pages 343-351
Myocardial Na,K-ATPase Concentration and Heart Failure....Pages 353-365
The Cytosolic Calcium-Force Relation of Vascular Smooth Muscle during the Contraction and the Relaxation....Pages 367-378
Front Matter....Pages 379-379
Ventricular Remodeling Following Coronary Artery Constriction and Hypertension....Pages 381-400
Collagenous Proteins in Scar Tissue Subsequent to Myocardial Infarction....Pages 401-414
Structural Remodeling and Functional Changes in Chronic Hypoxia-Induced Right Ventricular Hypertrophy....Pages 415-426
Mechanism of Openings and Role of the ATP-Sensitive K + Channels during Myocardial Ischemia/Reperfusion....Pages 427-437
The Contribution of K + Currents to Electrical Heterogeneity Across the Canine Ventricular Wall under Normal and Ischemic Conditions....Pages 439-456
Diabetic State Reduces Ischemic K + Loss and H + Efflux in Isolated Rat Hearts....Pages 457-468
Divergent Effects of Receptor- and Nonreceptor-Mediated Activators of Sodium-Hydrogen Exchange on Reperfusion-Induced Contractile Dysfunction....Pages 469-484
Heart Cells in Culture for Studying Anoxia and “Simulated Ischemia” at the Cellular Level....Pages 485-500
Cardioprotection and Basic Fibroblast Growth Factor....Pages 501-518
The Heart and Nitric Oxide....Pages 519-525
The Endothelium and the Regulation of Coronary Blood Flow....Pages 527-542
Signal Transduction in Vascular Smooth Muscle: Synergistic Interactions Between Receptors and Transduction Pathways....Pages 543-549
Modulation of Peak Aerobic Capacity by the Peripheral Circulation During the Course of The Syndrome of Congestive Heart Failure....Pages 551-556
Back Matter....Pages 557-578